Abstract:
OBJECTIVE:To test whether salvage radiotherapy (SRT) in patients with lymph node negative (N0) prostate cancer is equally effective with persistent prostate-specific antigen (PSA) and PSA rising from the undetectable range (<0.1 ng/mL) after radical prostatectomy (RP). PATIENTS AND METHODS:We assessed post-SRT PSA progression-free survival (PFS) in 555 patients with prostate cancer. The entire cohort was compared with a risk-adjusted subgroup of 112 patient pairs with matching pre-RP PSA level (±10 ng/mL), Gleason score (≤6 vs 7 vs ≥8), and pre-SRT PSA level (±0.5 ng/mL). RESULTS:The median follow-up was 6.1 years. After RP, PSA was undetectable in 422 and persistent in 133 patients. PSA persistence and a pre-SRT PSA level of ≥0.5 ng/mL reduced Kaplan-Meier rates of PFS significantly. In multivariate analysis of the entire cohort and after risk adjustment, the pre-SRT PSA level but not post-RP PSA persistence was a significant parameter. In the matched cohort's subgroup with early SRT at a PSA level of <0.5 ng/mL, a trend towards a worse outcome with post-RP PSA persistence was observed. Delayed SRT with a PSA level ≥0.5 ng/mL led to a PFS of <30%, irrespective of the post-RP PSA level. CONCLUSION:In patients with N0 prostate cancer with post-RP PSA persistence, early SRT at a PSA level <0.5 ng/mL seems to be less effective than in recurrent patients with post-RP undetectable PSA. They might benefit from intensified therapy, but larger case numbers are required to substantiate this conclusion. In patients with a PSA level ≥0.5 ng/mL and higher-risk features associated with post-RP PSA persistence, SRT alone is unlikely to provide long-term freedom from further progression.
journal_name
BJU Intjournal_title
BJU internationalauthors
Bartkowiak D,Siegmann A,Böhmer D,Budach V,Wiegel Tdoi
10.1111/bju.14851subject
Has Abstractpub_date
2019-11-01 00:00:00pages
785-791issue
5eissn
1464-4096issn
1464-410Xjournal_volume
124pub_type
杂志文章abstract:OBJECTIVE:To evaluate the influence of a high-oxalate/low-calcium diet on calcium oxalate stone risk factors in both black South Africans (who are largely immune to kidney stones) and white South Africans (in whom stones are more common). SUBJECTS AND METHODS:Urinary and dietary variables were examined in 11 black and...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00064.x
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To use information from genetic polymorphisms and from patients (drinking/exercise habits) to identify their association with stone disease, the main analytical and predictive tools being discriminant analysis (DA) and artificial neural networks (ANNs). PATIENTS, SUBJECTS AND METHODS:Urinary stone disease is...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1046/j.1464-410x.2003.03067.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To report a national questionnaire survey of all consultant urologists, providing a 'snapshot' of attitudes, current practice and referral patterns for radical prostatectomy (RP) in Britain and Ireland at the millennium. METHODS:During 1999/2000 a simple questionnaire about RP was sent to the 487 urologists ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02906.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To determine the effect of a deep and narrow pelvis on apical positive surgical margins (PSM) at radical prostatectomy (RP), controlling for other clinical and pathological variables and surgical approach, i.e. open retropubic (RRP) vs laparoscopic (LRP), as apical dissection is expected to be more challengin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09184.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the oncological outcome and functional results of prostate-sparing cystectomy (PSC), proposed for treating bladder cancer, used since 1999 in our institution in an attempt to preserve male sexuality and to increase continence after cystectomy. PATIENTS AND METHODS:Between January 1999 and Decembe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05097.x
更新日期:2004-11-01 00:00:00
abstract:STUDY TYPE:Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data. PATIENTS AND METHODS:This retrospective study included 34 patients treated between October 1997 and October 2007 (...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08813.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. RESULTS:P...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.07173.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To determine whether the rate of change in total serum prostate-specific antigen (PSA) levels accurately detects prostate cancer and to evaluate whether it adds any predictive value to a single measurement of serum PSA alone, in general practice settings. MATERIALS AND METHODS:A retrospective cohort of 219,3...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11651.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To devise a procedure capable of curing complicated ureteric strictures and replacing segments of lost ureter, without the long-term infective complications of bowel interposition or the surgical magnitude of autotransplantation. PATIENTS AND METHODS:Four patients with complicated strictures and one with seg...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00019.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria. PATIENTS AND METHODS:We conducted a retrospective single-centre analysis of 247 consecutive patients. The recruitment period was January 2001 to October 2015. A total of 328 inflata...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14027
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To validate high-sensitivity C-reactive protein (hs-CRP) serum levels as an independent marker for disease-free survival (DFS) in clinically localised clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:In all, 403 consecutive patients with clinically localised (T1-3N0M0) ccRCC treated by radical o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12067
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To provide data on the prevalence of urinary, bowel and sexual dysfunction in Northern Ireland (NI), to act as a baseline for studies of prostate cancer outcomes and to aid service provision within the general population. SUBJECTS AND METHODS:A cross-sectional postal survey of 10 000 men aged ≥40 years in N...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14182
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To determine if athermal methods are as effective in preventing blood transfusions as the use of cautery across various prostate volumes following prostate tissue resection for benign prostatic hyperplasia using Aquablation. PATIENTS AND METHODS:The current commercial AQUABEAM robot that performs Aquablation...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14990
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To compare the effect of allowing patients to watch their cystoscopy on closed-circuit television and with an explanation during the procedure, with an explanation alone, as involving patients in the process of minimally invasive procedures like colonoscopy or colposcopy has been reported to alleviate pain an...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2003.04477.x
更新日期:2003-11-01 00:00:00
abstract:UNLABELLED:OBJECTIVE • To determine how the presence of MP on T1 biopsy specimens affects the outcome of patients undergoing RC as compared to when no MP is identified in the TURBT specimen. PATIENTS AND METHODS:• Patients were retrospectively identified from the Columbia University Urologic Oncology Database. • From ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09893.x
更新日期:2011-10-01 00:00:00
abstract::• Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. • If this is not possible on imaging criteria then biopsy can...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11618.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To estimate the population-based conditional 5-year relative survival rates for patients with prostate cancer (PCa). PATIENTS AND METHODS:All 98 672 patients, aged 45-89 years, diagnosed in the Netherlands with PCa (clinical T stage 1-4) in the period 1989-2008 were selected from the Netherlands Cancer Regis...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12519
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in protein leakage in the glomerular filtration barrier, and in the ability of the tubule to reabsorb proteins during and after acute urinary retention (AUR). PATIENTS AND METHODS:Glomerular and tubular function was investigated in 24 men during AUR (mean age 68 years, mean retention time...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02047.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:To investigate the associations of host metabolic factors and metabolic syndrome on prostate cancer-specific death (PCSD) and overall survival (OS) in patients treated with androgen deprivation therapy (ADT) for biochemically recurrent disease. PATIENTS AND METHODS:The analysis included 273 patients with pr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13428
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02981.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:To investigate the receptors for angiotensin II (AII, reported to be a potent contractile agent in human urinary bladder), using functional and autoradiographic techniques in child and adult bladder specimens. Materials and methods Bladder specimens were obtained from 61 children (aged 4 months to 12 years) ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00771.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:To investigate scores and predictors of patient satisfaction at 1 year after penile prosthesis implantation (PPI) using the validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. PATIENTS AND METHODS:Analyses were performed for 142 patients prospectively included in the natio...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14462
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:• To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). • To evaluate their potential clinical implementation in a preoperative setti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10059.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUCs) has an impact on oncological outcomes. PATIENTS AND METHODS:We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to Septe...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.14053
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To assess the clinical effect of the 'prostatic urethral lift' (PUL) on lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) through a crossover design study. PATIENTS AND METHODS:Men aged ≥ 50 years with an International Prostate Symptom Score of ≥ 13, a maximum urinary flo...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.12540
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:• To evaluate whether current nephrectomy pathology reports are sufficient to allow clinicians to use prognostic nomograms, tailor surveillance, enroll patients into adjuvant trials and select systemic therapy for renal cell carcinoma (RCC). PATIENTS AND METHODS:• Nephrectomy pathology reports were obtained ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09871.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To report the long-term results with the Mainz Pouch II procedure. PATIENTS AND METHODS:Between 1990 and 2000 a Mainz Pouch II ureterosigmoidostomy was used in 123 patients (49 females and 74 males, mean age 43.6 years, range: 1-73). The indications for urinary diversion were cystectomy for bladder cancer in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2003.04777.x
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To describe our current procedure of robot-assisted laparoscopic radical prostatectomy (RALP), and to assess the effect of the learning curve on perioperative data, early oncological outcomes and functional results, as RALP has increasingly become a treatment option for men with localized prostate cancer. PA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09013.x
更新日期:2010-04-01 00:00:00
abstract:UNLABELLED:Authors from Iowa City report on the incidence of RCC; they compared the rate of these tumours at autopsy and felt that the decrease found was a result of better antemortem detection, and an increase with time in the frequency of clinically detected renal cancer. A study from New York attempted to determine ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05244.x
更新日期:2005-01-01 00:00:00