Zoledronic acid is effective in preventing and delaying skeletal events in patients with bone metastases secondary to genitourinary cancers.

Abstract:

:Patients with metastatic bone disease often have severe bone pain and debilitating skeletal complications. Zoledronic acid is the only bisphosphonate shown to be safe and effective in reducing skeletal-related events (SREs), including pathological fractures, spinal cord compression, and radiation or surgery to bone in patients with bone metastases from advanced prostate cancer or renal cell carcinoma (RCC). In both tumour types, zoledronic acid significantly decreased the overall risk of developing an SRE, delayed their onset and significantly reduced the incidence of SREs compared with placebo. In patients with RCC, zoledronic acid also significantly delayed the time to progression of bone lesions by 5 months compared with placebo. Zoledronic acid is safe and well tolerated with long-term use.

journal_name

BJU Int

journal_title

BJU international

authors

Saad F,Lipton A

doi

10.1111/j.1464-410X.2005.05740.x

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

964-9

issue

7

eissn

1464-4096

issn

1464-410X

pii

BJU5740

journal_volume

96

pub_type

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