Abstract:
OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initially diagnosed with T4 prostate cancer, considered primarily as inoperable because of a fixed mass defined by rectal examination in combination with high PSA level and/or large foci of biopsy confirmed undifferentiated prostate cancer. Treatment consisted of primary ADT until PSA nadir with consecutive RP. Patients underwent retropubic RP (RRP) or robot-assisted laparoscopic RP (RALP) after inductive ADT until achievement of the PSA nadir, which is in general reached after 6-7 months. The intraoperative course and complications were analysed. Finally, Kaplan-Meier estimates were calculated for overall survival (OS) and prostate cancer-specific survival (PCSS). RESULTS:We retrospectively identified 116 patients treated between 2000 and 2014. At diagnosis, the median (range) PSA level was 37.6 (2.44-284) ng/mL. The preoperative median (range) PSA after inductive ADT was 0.73 (0.01-34) ng/mL. Thereafter, patients underwent RRP or, since 2006, RALP. The median (95% confidence interval) OS was 156 (118.9-193.1) months. The PCSS at 150 months was 82%. CONCLUSIONS:Surgical therapy of primarily inoperable prostate cancer is feasible and safe after inductive ADT. The OS of this cohort seems comparable with results described for patients with primary operable high-risk prostate cancer.
journal_name
BJU Intjournal_title
BJU internationalauthors
Hajili T,Ohlmann CH,Linxweiler J,Niklas C,Janssen M,Siemer S,Stoeckle M,Saar Mdoi
10.1111/bju.14393subject
Has Abstractpub_date
2019-01-01 00:00:00pages
58-64issue
1eissn
1464-4096issn
1464-410Xjournal_volume
123pub_type
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.12992
更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11745.x
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05504.x
更新日期:2005-06-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-03-01 00:00:00
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06800.x
更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09184.x
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01429.x
更新日期:2001-12-01 00:00:00
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更新日期:2003-03-01 00:00:00