Abstract:
OBJECTIVE:To examine the association between diabetes and metastasis risk after radical prostatectomy (RP) and to determine if race or obesity modifies this relationship. PATIENTS AND METHODS:Patients comprised 2058 US veterans with prostate cancer (PCa) enrolled in the Shared Equal-Access Regional Cancer Hospital (SEARCH) database and treated with RP between 1988 and 2010. The association of diabetes with metastasis risk or secondary treatment rates was examined using Cox proportional hazards, adjusting for preoperative and, separately, clinical and postoperative findings. The effect modification by race (black vs white) and obesity (body mass index [BMI] ≥30 vs <30 kg/m(2) ) was tested via interaction terms. RESULTS:Men with diabetes had higher BMIs and were more likely to be non-white (all P ≤ 0.001). On multivariable analysis, diabetes was not associated with metastasis risk (P ≥ 0.45), but, among men with diabetes, longer diabetes duration was associated with higher metastasis risk (P ≤ 0.035). When stratified by obesity, diabetes was linked with higher metastasis risk in obese but not in non-obese men (P-interaction ≤ 0.037), but there was no significant interaction with race (P-interaction ≥ 0.56). Diabetes also predicted more aggressive secondary treatment among obese men but less aggressive treatment among non-obese men (hazard ratio 1.39 vs 0.63, P-interaction = 0.006). Where applicable, results were similar for both pre- and postoperative models. CONCLUSIONS:Diabetes was not associated with metastasis risk overall. Stratification by obesity yielded significant differences, with diabetes linked to a fourfold higher metastasis risk in obese men, despite predicting more aggressive secondary treatment. Longer diabetes duration was also associated with increased metastasis risk.
journal_name
BJU Intjournal_title
BJU internationalauthors
Wu C,Aronson WJ,Terris MK,Presti JC Jr,Kane CJ,Amling CL,Freedland SJdoi
10.1111/j.1464-410X.2012.11687.xsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
E310-8issue
8eissn
1464-4096issn
1464-410Xjournal_volume
111pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13011
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To examine the utility of cyanoacrylate tissue adhesive (Dermabond, Ethicon, Somerville, NJ, USA; an effective means of epithelial skin closure) under a diaper (i.e. constantly exposed to bodily fluids) in 25 children (not toilet-trained) undergoing inguinal surgery. PATIENTS AND METHODS:A retrospective revi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02142.x
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:• o determine differences in surgical outcomes by surgical approach during a period of rapid adoption of minimally invasive surgical approaches in radical prostatectomy. PATIENTS AND METHODS:• We identified 19 542 men undergoing minimally invasive (MIRP), perineal (PRP), and retropubic (RRP) radical prostate...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09822.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To examine the prognostic significance of the expression of platelet-derived growth factor-BB (PDGF-BB) and differentiated microvascular density (MVD) in patients with clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:We used the vascular marker cluster of differentiation 34 (CD34) to identify tu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12191
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12517
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS:The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09890.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic accuracy of the Xpert Bladder Cancer (BC) Monitor, compared with cystoscopy and cytology in the oncological follow-up of non-muscle-invasive bladder cancer (NMIBC). MATERIAL AND METHODS:A total of 140 patients with a history of NMIBC undergoing routine surveillance at our institut...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14019
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after definitive local therapy. The objective of our present study was to summarise available evid...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2012.11527.x
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. MATERIALS AND METHODS:Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8 weeks; gr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08261.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:• To employ decision curve analysis to determine the impact of nuclear matrix protein 22 (NMP22) on clinical decision making in the detection of bladder cancer using data from a prospective trial. PATIENTS AND METHODS:• The study included 1303 patients at risk for bladder cancer who underwent cystoscopy, uri...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.010419.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that observation with early salvage radiotherapy (SRT) is not inferior to 'standard' treatment with adjuvant RT (ART) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins (SMs) after radical prostatectomy (RP). To compare the following secon...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.12623
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological asses...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09442.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over-expressed in several cancer cells, in bladder cancer and its association with patient prognosis and the response to adjuvant therapy. PATIENTS AND METHODS:In all, 67 bladder tissue specimens were obtained f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08099.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To report the overall success rate of a laparoscopic orchidopexy (LO) series over 5 years including over 100 procedures. PATIENTS AND METHODS:The records were reviewed of children who underwent laparoscopic procedures for an impalpable testis at our institutions. The laparoscopic procedures included the stan...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2001.00100.x
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12549
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00979.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and treatment of lymphoceles after retropubic radical prostatectomy (RP). PATIENTS AND METHODS:Up to January 2004, 260 patients who had a retropubic RP in one institution by one surgeon were assessed retrospectively, using the patients' notes or the computerized results system to d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05398.x
更新日期:2005-04-01 00:00:00
abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11270.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To present the template-guided transperineal prostate biopsy (TPB) outcomes for patients of two urologists from a single institution. PATIENTS AND METHODS:We conducted a prospective study of 409 consecutive men who underwent TPB between December 2006 and June 2008 in a tertiary referral centre using a standa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11657.x
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To identify, in a retrospective study, possible molecular markers predictive of radioresponsiveness in patients with transitional cell carcinoma (TCC) of the bladder. PATIENTS AND METHODS:Patients with T2-T4a TCC treated with preoperative radiotherapy and cystectomy were included in the study if their cystec...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02268.x
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To compare the demographic, behavioural, clinical and medical history characteristics of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and asymptomatic controls, to identify characteristics that might be associated with this syndrome. PATIENTS AND METHODS:Self-administered epidemiologic...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05684.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:• To assess the feasibility of radical prostatectomy (RP) in a series of patients with prostate cancer with very high prostate-specific antigen (PSA) levels by comparing the clinical outcomes of different PSA thresholds (20.1-50 ng/mL, 50.1-100 ng/mL and >100 ng/mL, respectively). PATIENTS AND METHODS:• With...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10076.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To assess the clinical pattern of progression and prostate-specific antigen doubling time (PSA-DT) after exposure to docetaxel-based chemotherapy in patients with androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:Fifty-five patients received docetaxel-based chemotherapy; data were collected r...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.07037.x
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:To prospectively evaluate the accuracy of transvesical contrast-enhanced ultrasound (CEUS) as an alternative method for the detection of anastomotic leakage after radical retropubic prostatectomy (RRP) in comparison with the current standard method of conventional retrograde cystography (CG). PATIENTS AND...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09497.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12732
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:• To present a summary of the collected data on urological litigation within the UK National Health Service (NHS). • Knowledge of the main areas of litigation is essential for maintaining good clinical practice as well as risk management procedures in any specialty. MATERIALS AND METHODS:• Details of all cl...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10130.x
更新日期:2011-07-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Despite expanding treatment options for castration-resistant prostate cancer (CRPC), therapies with long response duration remain intangible due to prostate cancer cells' natural ability to develop it...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11456.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of fluoroquinolone prophylaxis in patients undergoing transrectal ultrasonography (TRUS)-guided biopsy of the prostate in the Norwich population, and its correlation with ciprofloxacin resistance in the faecal flora. We also aimed to determine the usefulness of a pre-biopsy rectal sc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12865
更新日期:2015-07-01 00:00:00
abstract:UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10778.x
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of inside-out transobturator tape (tension-free vaginal tape-obturator, TVT-O) for the treatment of stress urinary incontinence (SUI). PATIENTS AND METHODS:Between August 2004 and August 2006, 87 consecutive patients with SUI who underwent TVT-O were enrolle...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14555
更新日期:2019-05-01 00:00:00