Abstract:
OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core transrectal ultrasonography (TRUS)-guided biopsy in a primary or rebiopsy setting. The overall DR, the DR of a 10-core randomized, RTE targeted biopsy and the incremental DR were calculated. RESULTS:Overall, randomized and RTE targeted biopsy DRs (for the combination, the 10-core and the four-core RTE biopsy scheme) were 46.2% (n = 473), 39.1% (n = 400) and 29.0% (n = 297), respectively. Four-core RTE targeted biopsies detected an additional 73 patients not detected by the 10-core randomized biopsies (increase in the overall DR of 7.1%). This represented a relative increase in DR of 18.3%. The incremental DR was better in rebiopsy patients (24.8%) than in patients having their first biopsy (14.7%). Within all patients diagnosed by RTE targeted biopsy only, 34 patients harboured significant Gleason 4 or 5 prostate cancer (PCa), diagnosed by four-core RTE biopsy only. Moreover, PCa with a Gleason grade of 4 or 5 was detected by four-core RTE biopsies in 30 patients, who showed low-grade PCa ≤ Gleason 3 only in the systematic 10-core biopsy. CONCLUSIONS:Real-time elastography targeted biopsy seems to be an appropriate method for increasing the DR of PCa. Nevertheless, RTE targeted biopsies missed a high proportion of patients with PCa and should therefore be considered as an addition to randomized biopsies.
journal_name
BJU Intjournal_title
BJU internationalauthors
Salomon G,Drews N,Autier P,Beckmann A,Heinzer H,Hansen J,Michl U,Schlomm T,Haese A,Steuber T,Graefen M,Becker Adoi
10.1111/bju.12517subject
Has Abstractpub_date
2014-04-01 00:00:00pages
548-53issue
4eissn
1464-4096issn
1464-410Xjournal_volume
113pub_type
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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journal_title:BJU international
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pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2012-01-01 00:00:00
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