Inhibitory effect of sildenafil on the human isolated seminal vesicle.

Abstract:

OBJECTIVE:To investigate the effects of sildenafil on noradrenaline- and potassium-induced contractions of isolated human seminal vesicles (SVs), as premature ejaculation is a relatively common male sexual dysfunction that currently lacks an adequate therapy, and recent in vitro tests showed that sildenafil induces relaxation of rodent isolated SVs, but it is not known whether it also inhibits isolated human SV. MATERIAL AND METHODS:Isolated strips of human SVs were suspended in an organ bath and cumulative concentration-response curves to either noradrenaline or KCl were constructed in the presence and absence of sildenafil to evaluate its inhibitory actions. RESULTS:Sildenafil (25-100 microm) induced concentration-dependent inhibitory effects on the human SV contracted by either noradrenaline or KCl. These actions of sildenafil do not therefore appear to be mediated via a competitive antagonism of alpha-adrenoceptors and are consistent with its recognized ability to inhibit phosphodiesterase-5. CONCLUSIONS:The present results show an important inhibitory action of sildenafil in the isolated human SV, supporting the therapeutic indication of this drug for treating premature ejaculation.

journal_name

BJU Int

journal_title

BJU international

authors

Gajar SA,Tano T,Resende AC,Bitencourt JA,de Lemos Neto M,Damião R,Criddle DN,Soares de Moura R

doi

10.1111/j.1464-410X.2007.07260.x

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1322-5

issue

6

eissn

1464-4096

issn

1464-410X

pii

BJU7260

journal_volume

100

pub_type

杂志文章
  • Natural history of 'second' biochemical failure after salvage radiation therapy for prostate cancer: a multi-institution study.

    abstract:OBJECTIVES:To describe the natural history of prostate cancer in men who experience a second biochemical recurrence (BCR) after salvage radiotherapy (SRT) after prostatectomy. PATIENTS AND METHODS:After undergoing SRT at one of two institutions between 1986 and 2013, 286 patients experienced a second BCR, defined as t...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13926

    authors: Tumati V,Jackson WC,Abugharib AE,Raj G,Roehrborn C,Lotan Y,Courtney K,Bagrodia A,Gahan JC,Zumsteg ZS,Folkert MR,Laine AM,Hannan R,Spratt DE,Desai NB

    更新日期:2018-03-01 00:00:00

  • Glycosylated haemoglobin levels and the severity of erectile function in diabetic men.

    abstract:OBJECTIVE:To evaluate the association between the levels of glycosylated haemoglobin (HbA1c) and the severity of erectile dysfunction (ED) in men with diabetes mellitus (DM). PATIENTS AND METHODS:This cross-sectional study included sexually active men with a diagnosis of DM attending a urological medical centre from J...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05349.x

    authors: Rhoden EL,Ribeiro EP,Riedner CE,Teloken C,Souto CA

    更新日期:2005-03-01 00:00:00

  • Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones.

    abstract:OBJECTIVE:To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS:The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09890.x

    authors: Safarinejad MR,Shafiei N,Safarinejad S

    更新日期:2011-07-01 00:00:00

  • Laser robotically assisted nerve-sparing radical prostatectomy: a pilot study of technical feasibility in the canine model.

    abstract:OBJECTIVES:To examine the feasibility of using laser energy during nerve-sparing robotically assisted radical prostatectomy (RARP), as the energy sources currently used for haemostasis in RARP adversely affect cavernous nerve function, while clips require application by a skilled assistant, but laser energy potentially...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07708.x

    authors: Gianduzzo T,Colombo JR Jr,Haber GP,Hafron J,Magi-Galluzzi C,Aron M,Gill IS,Kaouk JH

    更新日期:2008-08-05 00:00:00

  • Renal functional outcomes for tumours in a solitary kidney managed by ablative or extirpative techniques.

    abstract:OBJECTIVE:To present the renal functional outcomes for patients treated with open partial nephrectomy (OPN) or radiofrequency ablation (RFA) for tumours in a solitary kidney, as renal masses in a solitary kidney present a challenging treatment dilemma. PATIENTS AND METHODS:A retrospective review of institutional datab...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2009.08776.x

    authors: Raman JD,Raj GV,Lucas SM,Williams SK,Lauer EM,Ahrar K,Matin SF,Leveillee RJ,Cadeddu JA

    更新日期:2010-02-01 00:00:00

  • Preoperative predictors of renal function decline after radical nephroureterectomy for upper tract urothelial carcinoma.

    abstract:OBJECTIVES:To model renal function after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). To identify predictors of renal function decline after surgery, thereby allowing the identification of patients likely to be ineligible for cisplatin-based chemotherapy in the adjuvant setting. PATIEN...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12597

    authors: Kaag M,Trost L,Thompson RH,Favaretto R,Elliott V,Shariat SF,Maschino A,Vertosick E,Raman JD,Dalbagni G

    更新日期:2014-11-01 00:00:00

  • Detection of clinical unilateral T3a prostate cancer - by digital rectal examination or transrectal ultrasonography?

    abstract:OBJECTIVE:To assess, in a retrospective study, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and the combination of both in unilateral clinical T3a (cT3a) prostate cancer. PATIENTS AND METHODS:Th...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06452.x

    authors: Hsu CY,Joniau S,Oyen R,Roskams T,Van Poppel H

    更新日期:2006-11-01 00:00:00

  • Impact of medical therapy on transurethral resection of the prostate: two decades of change.

    abstract:OBJECTIVE:• To examine how the introduction of medical therapy for symptomatic benign prostatic hyperplasia (BPH) might have changed the indications, patient characteristics and outcomes in men undergoing transurethral resection of the prostate (TURP) over two decades (1988-2008). PATIENTS AND METHODS:• All patients w...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09737.x

    authors: Izard J,Nickel JC

    更新日期:2011-07-01 00:00:00

  • GreenLight HPS™ 120-W laser vaporization vs transurethral resection of the prostate (

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a sho...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2011.10878.x

    authors: Pereira-Correia JA,de Moraes Sousa KD,Santos JB,de Morais Perpétuo D,Lopes-da-Silva LF,Krambeck RL,Muller VJ,Vaz FP

    更新日期:2012-10-01 00:00:00

  • Diabetes predicts metastasis after radical prostatectomy in obese men: results from the SEARCH database.

    abstract:OBJECTIVE:To examine the association between diabetes and metastasis risk after radical prostatectomy (RP) and to determine if race or obesity modifies this relationship. PATIENTS AND METHODS:Patients comprised 2058 US veterans with prostate cancer (PCa) enrolled in the Shared Equal-Access Regional Cancer Hospital (SE...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11687.x

    authors: Wu C,Aronson WJ,Terris MK,Presti JC Jr,Kane CJ,Amling CL,Freedland SJ

    更新日期:2013-06-01 00:00:00

  • Vascular endothelial growth factor and mTOR pathways in renal cell carcinoma: differences and synergies of two targeted mechanisms.

    abstract::Renal cell carcinoma (RCC) is among the most resistant tumours to chemotherapy, radiotherapy and hormonal therapy. Cytokine therapy is effective in a small subset of patients, but it is associated with substantial toxicity and rarely benefits patients with extensive tumour burdens or adverse prognostic factors. Since ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2009.08987.x

    authors: Mulders P

    更新日期:2009-12-01 00:00:00

  • National bias in citations in urology journals: parochialism or availability?

    abstract:OBJECTIVE:To determine any bias by authors of different nationalities in their citation rate of selected urological journals in papers published in the British Journal of Urology and the Journal of Urology. METHODS:Using a simple computer program and text files of accepted reports in the BJU, or those available on CD-...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00267.x

    authors: Grange RI

    更新日期:1999-10-01 00:00:00

  • Changes in body composition, muscle function and energy expenditure after radical cystectomy.

    abstract:OBJECTIVE:To determine the changes in body composition, muscle function and energy expenditure after radical cystectomy (RC). PATIENTS AND METHODS:Eleven consecutive men (median age 66 years, range 44-79) who had a RC over a 1-year period had measurements made of their total body protein, by neutron-activation analysi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07337.x

    authors: Mathur S,Plank LD,Hill AG,Rice MA,Hill GL

    更新日期:2008-04-01 00:00:00

  • Secular trends in prostate cancer mortality, incidence and treatment: England and Wales, 1975-2004.

    abstract:OBJECTIVE:To aid the interpretation of the trends in prostate cancer mortality, which declined in the UK in the early 1990 s for unknown reasons, by investigating prostate cancer death rates, incidence and treatments in England and Wales in 1975-2004. METHODS:Join-point regression was used to assess secular trends in ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07338.x

    authors: Hussain S,Gunnell D,Donovan J,McPhail S,Hamdy F,Neal D,Albertsen P,Verne J,Stephens P,Trotter C,Martin RM

    更新日期:2008-03-01 00:00:00

  • The role of targeted prophylactic antimicrobial therapy before transrectal ultrasonography-guided prostate biopsy in reducing infection rates: a systematic review.

    abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.13402

    authors: Cussans A,Somani BK,Basarab A,Dudderidge TJ

    更新日期:2016-05-01 00:00:00

  • The sexual habits of British men and women over 40 years old.

    abstract:OBJECTIVE:To obtain a greater understanding of sexual behaviour and habits among men with and without erectile dysfunction (ED), and their female partners, to improve the management of ED in heterosexual men. SUBJECTS AND METHODS:A population-based study was conducted amongst men and women aged > 40 years. None of the...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410x.2003.04684.x

    authors: Eardley I,Dean J,Barnes T,Kirby M,Glasser D,Solanki J

    更新日期:2004-03-01 00:00:00

  • Design and evaluation of an image-guidance system for robot-assisted radical prostatectomy.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Systems for image guidance during laparoscopic surgery can be broadly defined as systems that enable the surgeon to refer to preoperatively gathered information during the procedure. For a laparoscopic system the preoperative information can be overl...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11692.x

    authors: Thompson S,Penney G,Billia M,Challacombe B,Hawkes D,Dasgupta P

    更新日期:2013-06-01 00:00:00

  • Assessing the anatomical characteristics of renal masses has a limited effect on the prediction of pathological outcomes in solid, enhancing, small renal masses: results using the PADUA classification system.

    abstract:OBJECTIVE:To evaluate whether assessing the anatomical characteristics of renal masses increases the accuracy of prediction of tumour pathology in small renal masses (SRMs). PATIENTS AND METHODS:We retrospectively reviewed 1129 consecutive patients who underwent extirpative surgeries for a clinical T1 renal mass, for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12446

    authors: Shin TY,Kim J,Koo KC,Lim SK,Kim DW,Kang MW,Rha KH,Choi YD,Ham WS

    更新日期:2014-05-01 00:00:00

  • The effects of recreational ketamine cystitis on urinary tract reconstruction - a surgical challenge.

    abstract:OBJECTIVES:To identify the rate of postoperative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor postoperative outcome with subsequent management strategies. PATIENTS AND METHODS:A retrospective review of data collecte...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14094

    authors: Sihra N,Ockrim J,Wood D

    更新日期:2018-03-01 00:00:00

  • Efficacy of nilutamide as secondary hormonal therapy in androgen-independent prostate cancer.

    abstract:OBJECTIVE:To evaluate the activity of nilutamide as secondary hormonal therapy in patients with androgen-independent prostate cancer (AIPC), as treatment options are limited for these patients and secondary hormonal therapy with antiandrogens has advantages, including low toxicity, oral administration and high patient ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2005.05714.x

    authors: Nakabayashi M,Regan MM,Lifsey D,Kantoff PW,Taplin ME,Sartor O,Oh WK

    更新日期:2005-10-01 00:00:00

  • Long-term oncological outcomes of patients with paratesticular sarcoma.

    abstract:OBJECTIVES:To present long-term oncological outcomes of patients with paratesticular sarcoma treated by a multidisciplinary team. PATIENTS AND METHODS:Patients managed at the Princess Margaret Cancer Centre, between 1990 and 2012, were analysed. A sarcoma expert performed central pathology review. Kaplan-Meier graphs ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14775

    authors: Goldberg H,Wong LM,Dickson B,Catton C,Yap SA,Alkasab T,Evans A,van der Kwast T,Jewett MAS,Hamilton RJ

    更新日期:2019-11-01 00:00:00

  • Bladder augmentation with different forms of intestinal grafts: an experimental study in the pig.

    abstract:OBJECTIVE:To create an experimental animal model to examine changes in bladder volume and histology after bladder augmentation in growing individuals and from the model, evaluate a method using demucosalized intestinal grafts and short-term bladder drainage. MATERIALS AND METHODS:The study comprised 21 piglets: in gro...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00895.x

    authors: Clementson Kockum C,Willén R,Malmfors G

    更新日期:1999-02-01 00:00:00

  • Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia.

    abstract:OBJECTIVE:To investigate whether fluid shear stress (FSS) induces endothelial nitric oxide synthase (eNOS) activity and NO production in isolated human corpus cavernosal endothelial cells (HCCECs), and whether this response is altered during hyperglycaemia in vitro, as haemodynamic signalling during penile erection ind...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06059.x

    authors: Wessells H,Teal TH,Engel K,Sullivan CJ,Gallis B,Tran KB,Chitaley K

    更新日期:2006-05-01 00:00:00

  • Diagnostic utility of a p63/alpha-methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy.

    abstract:OBJECTIVE:To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens. MATERIALS AND METHODS:Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overe...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06069.x

    authors: Molinié V,Hervé JM,Lugagne PM,Lebret T,Botto H

    更新日期:2006-05-01 00:00:00

  • Five-year data from the Oxford Laser Prostatectomy Trial.

    abstract:OBJECTIVE:To evaluate the natural history of a group of patients who underwent contact laser prostatectomy or transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were followed up at 5 years after enrolling in a prospective double-blind randomized controlled trial of TURP vs contact laser pros...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00778.x

    authors: Keoghane SR,Sullivan ME,Doll HA,Kourambas J,Cranston DW

    更新日期:2000-08-01 00:00:00

  • Robot-assisted radical cystectomy: intermediate survival results at a mean follow-up of 25 months.

    abstract:OBJECTIVE:To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. PATIENTS AND METHODS:Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tula...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2009.09042.x

    authors: Martin AD,Nunez RN,Pacelli A,Woods ME,Davis R,Thomas R,Andrews PE,Castle EP

    更新日期:2010-06-01 00:00:00

  • The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel.

    abstract:OBJECTIVE:To establish a consensus on the utility of multiparametric magnetic resonance imaging (mpMRI) to identify patients for focal therapy. METHODS:Urological surgeons, radiologists, and basic researchers, from Europe and North America participated in a consensus meeting about the use of mpMRI in focal therapy of ...

    journal_title:BJU international

    pub_type: 共识发展会议,杂志文章

    doi:10.1111/bju.12243

    authors: Muller BG,Fütterer JJ,Gupta RT,Katz A,Kirkham A,Kurhanewicz J,Moul JW,Pinto PA,Rastinehad AR,Robertson C,de la Rosette J,Sanchez-Salas R,Jones JS,Ukimura O,Verma S,Wijkstra H,Marberger M

    更新日期:2014-02-01 00:00:00

  • Benign scrotal pathology: should all patients undergo surgery?

    abstract:OBJECTIVE:To evaluate the justification for operative intervention in patients undergoing surgery for benign scrotal pathology, and to assess the associated morbidity. PATIENTS AND METHODS:Consecutive patients in two surgical firms who underwent surgery for benign intrascrotal pathology over a 5-year period were studi...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-410x.2001.02276.x

    authors: Menon VS,Sheridan WG

    更新日期:2001-08-01 00:00:00

  • Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in relation to the patient's risk profile for progression.

    abstract::Lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) is a slowly progressing disease, with some patients progressing more rapidly than others. In 80% of patients who progress this is caused by the worsening of symptoms. The physician can predict the risk of progression from the patient's ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2005.05488.x

    authors: Trachtenberg J

    更新日期:2005-06-01 00:00:00

  • Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy.

    abstract:OBJECTIVE:To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). PATIENTS AND METHODS:We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between Janu...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12329

    authors: Hattori S,Kosaka T,Mizuno R,Kanao K,Miyajima A,Yasumizu Y,Yazawa S,Nagata H,Kikuchi E,Mikami S,Jinzaki M,Nakagawa K,Tanimoto A,Oya M

    更新日期:2014-05-01 00:00:00