Abstract:
OBJECTIVE:To assess the clinical pattern of progression and prostate-specific antigen doubling time (PSA-DT) after exposure to docetaxel-based chemotherapy in patients with androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:Fifty-five patients received docetaxel-based chemotherapy; data were collected retrospectively from three different departments. Progression was known in 44 (79%) and the PSA-DT was available in 33 patients. RESULTS:Of the 29 patients with soft-tissue and soft-tissue plus bone metastases, 22 (76%) developed soft-tissue progression. Among the 35 patients with bone and bone plus soft-tissue metastases, 27 (77%) had osseous progression. There was no difference between the PSA-DT at progression before and after docetaxel-based therapy (mean 3.1 vs 2.7 months, P = 0.592, Student's t-test.). However, the median (range) PSA-DT at progression after docetaxel-based therapy was 0.84 (0.3-4) months in patients with a PSA response, significantly shorter than the median of 3.1 (0.3-12) months of patients with no biochemical response (P = 0.002, Student's t-test). The PSA-DT dynamics at progression had no effect on survival (P = 0.63, log-rank test). CONCLUSION:The pattern of progression after docetaxel-based chemotherapy is predominantly osseous in patient with bone metastases and mostly soft-tissue in those with soft-tissue disease. Progression after docetaxel-based chemotherapy in AIPC does not modify the PSA-DT before docetaxel. Evaluation of a larger population is needed to assess the clinical relevance of PSA dynamics after docetaxel therapy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Sella A,Sternberg C,Kovel S,Yarom N,Skoneczna Idoi
10.1111/j.1464-410X.2007.07037.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
533-5issue
3eissn
1464-4096issn
1464-410Xpii
BJU7037journal_volume
100pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To review our experience with orthotopic neobladder reconstruction (ONR) in women, highlighting functional and oncological outcomes, as ONR has been used increasingly for urinary diversion in women after radical cystectomy (RC), largely due to a better understanding of the natural history of urothelial cell c...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07909.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2008.08040.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, type and treatment behaviour of women with urinary incontinence in four European countries. SUBJECTS AND METHODS:Data were collected using a postal survey which was sent to 29,500 community-dwelling women aged > or = 18 years in France, Germany, Spain and the UK. Subjects were as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2003.04609.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To determine the safety, efficacy and pharmacokinetics of tolterodine in children with an overactive bladder. PATIENTS AND METHODS:Thirty-three children (20 boys and 13 girls, aged 5-10 years) with an overactive bladder and symptoms of urgency, frequency and/or urge incontinence were enrolled in an open, dos...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.2001.00084.x
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical significance of hypertension (HTN), neutropaenia and thrombocytopaenia as possible new biomarkers of sunitinib efficacy in non-trial patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:In all, 181 consecutive patients with mRCC were treated with sunitinib; 39 ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12940
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00140.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To address concerns about the impact of training on patient outcomes during the 'learning curve' for laparoscopic radical prostatectomy (LRP), we compare the results of our patients undergoing LRP with and without trainees performing a substantial proportion of the cases. PATIENTS AND METHODS:In all, 771 con...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08262.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To identify a phenotype that could be informative and prognostic in patients with renal cell carcinoma (RCC) peripheral blood was evaluated for TH1, TH2, regulatory T cells (Tregs), natural killer (NK) and NKT cells and for cytokines/chemokines. PATIENTS AND METHODS:Peripheral blood from 77 patients with RCC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12068
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of nocturia in the Dutch adult population, its association with sociodemographic and health characteristics, and to assess problems experienced by persons with nocturia. SUBJECTS AND METHODS:In spring 2001 a telephone survey was conducted among a representative sample of 4721 Dutch...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03011.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:• To present a summary of the collected data on urological litigation within the UK National Health Service (NHS). • Knowledge of the main areas of litigation is essential for maintaining good clinical practice as well as risk management procedures in any specialty. MATERIALS AND METHODS:• Details of all cl...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10130.x
更新日期:2011-07-01 00:00:00
abstract:UNLABELLED:To determine whether dendritic cells (DC) transduced with the prostate-specific antigen (PSA) gene can induce PSA-specific cytotoxic lymphocytes (CTL) against prostate cancer cells, and whether bacillus Calmette-Guérin (BCG) cell-wall skeleton (CWS) can enhance the maturation of DC-PSA and the killing activi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2009.08703.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To report a simplified and effective method for substratification of M1 castrate-resistant prostate cancer (CRPC) by correlating progression-free (PFS) and overall survival (OS) with simple quantification of skeletal metastases. PATIENTS AND METHODS:In all, 561 men with M1 CRPC were studied longitudinally. I...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12717
更新日期:2014-12-01 00:00:00
abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11270.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To study a novel penile reinnervation technique using four sural nerve grafts and end-to-side neurorraphies connecting bilaterally the femoral nerve and the cavernous corpus and the femoral nerve and the dorsal penile nerves. PATIENTS AND METHODS:Ten patients (mean [± sd; range] age 60.3 [± 4.8; 54-68] years...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13772
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To assess the possible relationship between treatment with selective serotonin-reuptake inhibitors (SSRIs) and the occurrence of nocturia. SUBJECTS AND METHODS:An unselected group of adult men and women, living in the city of Ostersund, Sweden, were sent a postal questionnaire containing questions on somatic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05408.x
更新日期:2005-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? L-dopa decarboxylase (DDC) has been documented as a novel co-activator of androgen receptor transcriptional activity. Recently, it was shown that DDC gene expression is significantly higher in patients with PCa than in those with BPH. In the present s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11152.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To examine the association between diabetes and metastasis risk after radical prostatectomy (RP) and to determine if race or obesity modifies this relationship. PATIENTS AND METHODS:Patients comprised 2058 US veterans with prostate cancer (PCa) enrolled in the Shared Equal-Access Regional Cancer Hospital (SE...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11687.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:• To employ decision curve analysis to determine the impact of nuclear matrix protein 22 (NMP22) on clinical decision making in the detection of bladder cancer using data from a prospective trial. PATIENTS AND METHODS:• The study included 1303 patients at risk for bladder cancer who underwent cystoscopy, uri...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.010419.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUCs) has an impact on oncological outcomes. PATIENTS AND METHODS:We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to Septe...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.14053
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To describe the preclinical pharmacology of Ro 115-1240, a peripherally acting selective alpha1A/1L-adrenoceptor (AR) partial agonist, compared with the alpha1A/1L-AR full agonist amidephrine, as AR agonists have some utility in the treatment of stress urinary incontinence (SUI) but are limited by undesirable...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2004.04577.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:• To investigate the influence of baseline variables on the 4-year incidence of acute urinary retention (AUR), benign prostatic hyperplasia (BPH)-related surgery and overall clinical progression in men treated with tamsulosin, dutasteride, or a combination of both. PATIENTS AND METHODS:• The 4-year Combinati...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2011.10124.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To determine the effectiveness of Uromune® in preventing recurrent urinary tract infections (UTIs) in women. PATIENTS AND METHODS:A total of 77 women with microbiology-proven recurrent UTIs were given Uromune sublingual vaccine for a period of 3 months. Time to first UTI recurrence since treatment and adver...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14067
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06496.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10968.x
更新日期:2012-11-01 00:00:00
abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.13402
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To explore patients' quality of life (QoL) during neoadjuvant hormone therapy (HT) using data from the Medical Research Council RT01 trial of standard- (64 Gy/32-fraction) and high- (74 Gy/37-fraction) dose radiotherapy (RT, both given conformally). PATIENTS AND METHODS:Of the 843 patients randomized to the ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2006.06560.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To compare changes in regional cerebral blood flow (rCBF), using positron emission tomography (PET), during chronic and acute sacral neuromodulation (SN). SN is an effective long-term treatment for chronic urge incontinence due to urinary bladder hyperactivity, as sensory nerves, spinal and supraspinal struct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06521.x
更新日期:2006-12-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Extracorporeal shockwave lithotripsy is effective for the treatment of paediatric renal stones with favourable short-term safety. Extracorporeal shockwave lithotripsy for treatment of paediatric renal stones is also safe for the kidney and the child ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11420.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To describe patient selection for sacral neuromodulation, also known as Interstim therapy, and the results of tined-lead implantation in the medium term. PATIENTS AND METHODS:In all, 49 patients, 39 with refractory overactive bladder symptoms and 10 with urinary retention, were implanted with the tined lead ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06508.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To investigate in a prospective, observational study whether transperineal prostate biopsy (TPbx) results in patient-reported quality-of-life (QoL) changes from baseline in the first 3-months after TPbx. PATIENTS AND METHODS:Consenting patients completed the 26-item Expanded Prostate cancer Index Composite (...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13413
更新日期:2016-07-01 00:00:00