Prognostic utility of biopsy-derived cell cycle progression score in patients with National Comprehensive Cancer Network low-risk prostate cancer undergoing radical prostatectomy: implications for treatment guidance.


OBJECTIVES:To determine the prognostic utility of the cell cycle progression (CCP) score in men with National Comprehensive Cancer Network (NCCN)-defined low-risk prostate cancer (PCa) undergoing radical prostatectomy (RP). PATIENTS AND METHODS:Men who underwent RP for Gleason score ≤6 PCa at three institutions (Martini Clinic [MC], Durham Veterans Affairs Medical Center [DVA] and Intermountain Healthcare [IH]) were identified. The CCP score was obtained from diagnostic (DVA, IH) or simulated biopsies (MC). The primary outcome was biochemical recurrence (BCR; prostate-specific antigen ≥0.2 ng/mL) after RP. The prognostic utility of the CCP score was assessed using Kaplan-Meier analysis and multivariable Cox proportional hazards models in the subset of men meeting NCCN low-risk criteria and in the overall cohort. RESULTS:Among the 236 men identified, 80% (188/236) met the NCCN low-risk criteria. Five-year BCR-free survival for the low (<0), intermediate (0-1) and high (>1) CCP score groups was 89.2%, 80.4%, 64.7%, respectively, in the low-risk cohort (P = 0.03), and 85.9%, 79.1%, 63.1%, respectively, in the overall cohort (P = 0.041). In multivariable models adjusting for clinical and pathological variables with the Cancer of the Prostate Risk Assessment (CAPRA) score, the CCP score was an independent predictor of BCR in the low-risk (hazard ratio [HR] 1.77 per unit score, 95% confidence interval [CI] 1.21, 2.58; P = 0.003) and overall cohorts (HR 1.41 per unit score, 95% CI 1.02, 1.96; P = 0.039). CONCLUSION:In a cohort of men with NCCN-defined low-risk PCa, the CCP score improved clinical risk stratification of men who were at increased risk of BCR, which suggests the CCP score could improve the assessment of candidacy for active surveillance and guide optimum treatment selection in these patients with otherwise similar clinical characteristics.




BJU international


Tosoian JJ,Chappidi MR,Bishoff JT,Freedland SJ,Reid J,Brawer M,Stone S,Schlomm T,Ross AE




Has Abstract


2017-12-01 00:00:00












  • Gene expression signatures prognostic for relapse in stage I testicular germ cell tumours.

    abstract:OBJECTIVES:To identify differentially expressed genes between relapsed and non-relapsed clinical stage I testicular germ cell tumours (TGCTs). MATERIALS AND METHODS:We reviewed patients with clinical stage I non-seminoma and seminoma from an institutional database (2000-2012) who were managed by active surveillance. P...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lewin J,Soltan Ghoraie L,Bedard PL,Hamilton RJ,Chung P,Moore M,Jewett MAS,Anson-Cartwright L,Virtanen C,Winegarden N,Tsao J,Warde P,Sweet J,Haibe-Kains B,Hansen AR

    更新日期:2018-11-01 00:00:00

  • Application of transcript profiling in formalin-fixed paraffin-embedded diagnostic prostate cancer needle biopsies.

    abstract:OBJECTIVE:To investigate the feasibility of transcript profiling in diagnostic formalin-fixed and paraffin-embedded (FFPE) biopsies for prostate cancer. MATERIALS AND METHODS:Laser-capture microdissection (LCM) was used to microdissect glandular epithelium as well as stromal tissue in archival prostate needle biopsies...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Rogerson L,Darby S,Jabbar T,Mathers ME,Leung HY,Robson CN,Sahadevan K,O'Toole K,Gnanapragasam VJ

    更新日期:2008-08-01 00:00:00

  • Emphysematous cystitis: a review of 135 cases.

    abstract:OBJECTIVE:To review recently published data on emphysematous cystitis (EC), a potentially life-threatening condition characterized by air within the bladder wall, and that most typically affects middle-aged diabetic women. METHODS:All articles published in English between 1956 and 2006 were identified using a Medline ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Thomas AA,Lane BR,Thomas AZ,Remer EM,Campbell SC,Shoskes DA

    更新日期:2007-07-01 00:00:00

  • Technical characterization of an ultrasound source for noninvasive thermoablation by high-intensity focused ultrasound.

    abstract:OBJECTIVE:To develop a generator for high-intensity focused ultrasound (HIFU, a method of delivering ultrasonic energy with resultant heat and tissue destruction to a tight focus at a selected depth within the body), designed for extracorporeal coupling to allow various parenchymal organs to be treated. MATERIAL AND M...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Köhrmann KU,Michel MS,Steidler A,Marlinghaus E,Kraut O,Alken P

    更新日期:2002-08-01 00:00:00

  • Endoluminal ultrasonography before retrograde endopyelotomy: can the results match laparoscopic pyeloplasty?

    abstract:OBJECTIVE:To present the results of endopyelotomy using endoluminal ultrasonography (EUS) to identify crossing vessels, as the success rates of endopyelotomy are generally lower than pyeloplasty, especially in patients with crossing vessels. PATIENTS AND METHODS:Forty-one consecutive patients who underwent EUS before ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Parkin J,Evans S,Kumar PV,Timoney AG,Keeley FX Jr

    更新日期:2003-03-01 00:00:00

  • Comparison of risk calculators from the Prostate Cancer Prevention Trial and the European Randomized Study of Screening for Prostate Cancer in a contemporary Canadian cohort.

    abstract:OBJECTIVE:•To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS:•At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Trottier G,Roobol MJ,Lawrentschuk N,Boström PJ,Fernandes KA,Finelli A,Chadwick K,Evans A,van der Kwast TH,Toi A,Zlotta AR,Fleshner NE

    更新日期:2011-10-01 00:00:00

  • Radical prostatectomy in Britain and Ireland at the millennium.

    abstract:OBJECTIVE:To report a national questionnaire survey of all consultant urologists, providing a 'snapshot' of attitudes, current practice and referral patterns for radical prostatectomy (RP) in Britain and Ireland at the millennium. METHODS:During 1999/2000 a simple questionnaire about RP was sent to the 487 urologists ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ravichandran S,Dasgupta P,Booth CM

    更新日期:2002-09-01 00:00:00

  • The effects of recreational ketamine cystitis on urinary tract reconstruction - a surgical challenge.

    abstract:OBJECTIVES:To identify the rate of postoperative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor postoperative outcome with subsequent management strategies. PATIENTS AND METHODS:A retrospective review of data collecte...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Sihra N,Ockrim J,Wood D

    更新日期:2018-03-01 00:00:00

  • Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancy.

    abstract:OBJECTIVE:To report experience with a minimally invasive technique for palliation of urinary fistula/incontinence complicating advanced pelvic malignancy or its treatment. PATIENTS AND METHODS:We used ureteric embolization with permanent nephrostomy drainage in eight renal units in five patients for palliation of symp...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Natarajan V,Boucher NR,Meiring P,Spencer P,Parys BT,Oakley NE,Stent (Society for Endourology in North Trent) Group.

    更新日期:2007-01-01 00:00:00

  • The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS.

    abstract:OBJECTIVE:• To examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively. PATIENTS AND METHODS:• A cross-sectional population-representative survey was conducted via the Internet in ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Coyne KS,Sexton CC,Kopp ZS,Ebel-Bitoun C,Milsom I,Chapple C

    更新日期:2011-11-01 00:00:00

  • Endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer.

    abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Sarosdy MF,Schellhammer PF,Soloway MS,Vogelzang NJ,Crawford ED,Presti J,Chodak GW,Mitchell P,Porter L

    更新日期:1999-05-01 00:00:00

  • Triple incision to treat phimosis in children: an alternative to circumcision?

    abstract:OBJECTIVE:To evaluate the functional and cosmetic results and patient satisfaction after triple incision plasty for phimosis in children. PATIENTS AND METHODS:The study included 197 boys who had a triple incision for phimosis (mean age 5.8 years, range 0.25-18). The indications for preputial surgery were recurrent bal...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Fischer-Klein Ch,Rauchenwald M

    更新日期:2003-09-01 00:00:00

  • The ability of the American Joint Committee on Cancer Staging system to predict progression-free survival after radical prostatectomy.

    abstract:OBJECTIVE:To examine, in a retrospective analysis of outcome based on prostate-specific antigen (PSA) levels, whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression-free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer. PATIENTS AND ME...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: May F,Hartung R,Breul J

    更新日期:2001-11-01 00:00:00

  • Risk factors for different phenotypes of hypospadias: results from a Dutch case-control study.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The various phenotypes of hypospadias may result from disturbances of dissimilar embryonic processes in different time windows, suggesting aetiological heterogeneity; however, only a few studies have investigated the risk factors for the different hy...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: van Rooij IA,van der Zanden LF,Brouwers MM,Knoers NV,Feitz WF,Roeleveld N

    更新日期:2013-07-01 00:00:00

  • Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging.

    abstract:OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Delongchamps NB,Rouanne M,Flam T,Beuvon F,Liberatore M,Zerbib M,Cornud F

    更新日期:2011-05-01 00:00:00

  • Laparoendoscopic single-site nephroureterectomy for upper urinary tract urothelial carcinoma: outcomes of an international multi-institutional study of 101 patients.

    abstract:OBJECTIVE:To report a large multi-institutional series of laparoendoscopic single-site (LESS) nephroureterectomy (NU). MATERIALS AND METHODS:Data on all cases of LESS-NU performed between 2008 and 2012 at 15 institutions were retrospectively gathered. The main demographic data and perioperative outcomes were analysed....

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Park SY,Rha KH,Autorino R,Derweesh I,Liastikos E,Tsai YC,Seo IY,Nagele U,Abdel-Karim AM,Herrmann T,Han DH,Rais-Bahrami S,Lee SW,Kim KS,Fornara P,Kallidonis P,Springer C,Élsalmy S,Chueh SC,Ho CH,Panumatrassamee K,

    更新日期:2013-09-01 00:00:00

  • Technical and equipment challenges for laparoendoscopic single-site surgery and natural orifice transluminal endoscopic surgery.

    abstract::Laparoendoscopic single-site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES™) are new approaches to minimally invasive surgery. A number of technical challenges need to be overcome and new developments of equipment are required before widespread acceptance of either modality occurs. In this ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Sawyer MD,Ponsky LE

    更新日期:2010-09-01 00:00:00

  • Retroperitoneal laparoscopic vs open partial nephroureterectomy in children.

    abstract:OBJECTIVES:To compare the results of retroperitoneal laparoscopic with open partial nephroureterectomy. PATIENTS AND METHODS:Laparoscopic retroperitoneal partial nephroureterectomy was undertaken in 15 children (13 upper and two lower poles; median age at the time of surgery 61 months, range 5-212). A three-trocar ret...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: El-Ghoneimi A,Farhat W,Bolduc S,Bagli D,McLorie G,Khoury A

    更新日期:2003-04-01 00:00:00

  • Trends in the surgical management of stage 1 renal cell carcinoma: findings from a population-based study.

    abstract:OBJECTIVES:To determine whether the use of nephron-sparing surgery (NSS) for treatment of stage 1 renal cell carcinoma (RCC) changed between 2009 and the end of 2013 in Australia. PATIENTS AND METHODS:All adult cases of RCC diagnosed in 2009, 2012 and 2013 were identified through the population-based Victorian Cancer ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: White V,Marco DJT,Bolton D,Davis ID,Jefford M,Hill D,Prince HM,Millar JL,Winship IM,Coory M,Giles GG

    更新日期:2017-11-01 00:00:00

  • Recoverability of renal functions after relief of partial ureteric obstruction of solitary kidney: impact of ferulic acid.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJEC...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Shokeir AA,Hussein AA,Soliman SA,Kamal MM,Abdel-Aziz A,Awadalla A,Rahim MA,Barakat N

    更新日期:2012-09-01 00:00:00

  • The prevalence of loss of heterozygosity in chromosome 3, including FHIT, in bladder cancer, using the fluorescent multiplex polymerase chain reaction.

    abstract:OBJECTIVE:To determine some of the genetic alterations involved in the pathogenesis and progression of transitional cell carcinoma of the bladder. Materials and methods In a population-based study, freshly frozen tissue was collected from all patients newly diagnosed with urinary bladder cancer in the Stockholm region ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Wada T,Louhelainen J,Hemminki K,Adolfsson J,Wijkström H,Norming U,Borgström E,Hansson J,Steineck G

    更新日期:2001-06-01 00:00:00

  • The outcome of artificial urinary sphincter placement after a mean 15-year follow-up in a paediatric population.

    abstract:OBJECTIVE:To evaluate the long-term outcome in children who had an artificial urinary sphincter (AUS) placed, after a minimum of 10 years of follow-up. PATIENTS AND METHODS:The medical records of patients who had an AUS placed at the Children's Hospital of Michigan were reviewed and a telephone questionnaire was then ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kryger JV,Spencer Barthold J,Fleming P,González R

    更新日期:1999-06-01 00:00:00

  • Does patient age affect survival after radical cystectomy?

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Elderly patients have more years to compound comorbidities and it has previously been shown that comorbidity is an important predictor of overall survival in patients with bladder cancer, including those treated with radical cystectomy (RC). Other stu...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Horovitz D,Turker P,Bostrom PJ,Mirtti T,Nurmi M,Kuk C,Kulkarni G,Fleshner NE,Finelli A,Jewett MA,Zlotta AR

    更新日期:2012-12-01 00:00:00

  • Comparison of peri-operative outcomes of robot-assisted vs laparoscopic partial nephrectomy: a meta-analysis.

    abstract:OBJECTIVE:To conduct a meta-analysis of the literature on the peri-operative outcomes of both robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS:An electronic database search of MEDLINE, EMBASE, Google Scholar and the Cochrane Library was performed for publicati...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang X,Shen Z,Zhong S,Zhu Z,Wang X,Xu T

    更新日期:2013-12-01 00:00:00

  • Overexpression of high mobility group box 1 with poor prognosis in patients after radical prostatectomy.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Recent studies have indicated that high mobility group box 1 (HMGB1) is related to the development and progression of human carcinomas. However, further studies were required to confirm the roles played by HMGB1 in clinical prostate cancer treatment. ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Li T,Gui Y,Yuan T,Liao G,Bian C,Jiang Q,Huang S,Liu B,Wu D

    更新日期:2012-12-01 00:00:00

  • Clinical outcomes of androgen deprivation as the sole therapy for localized and locally advanced prostate cancer.

    abstract:OBJECTIVE:To characterize the clinical outcomes of androgen deprivation therapy (ADT) as the sole therapy for localized prostate cancer, and to determine independent predictors of disease progression, as recent studies indicate an increasing use of ADT. PATIENTS AND METHODS:The records of all patients with cT1-4NXM0 a...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Janoff DM,Peterson C,Mongoue-Tchokote S,Peters L,Beer TM,Wersinger EM,Mori M,Garzotto M

    更新日期:2005-09-01 00:00:00

  • A new one-layer epididymovasostomy technique.

    abstract:OBJECTIVES:To describe and evaluate the outcomes of a new epididymovasostomy technique. PATIENTS AND METHODS:Nine patients with obstructive azoospermia were treated at the Minia University Hospital using a new microsurgical bilateral epididymovasostomy technique. The technique involved the opening of a small window in...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Hussein A

    更新日期:2015-04-01 00:00:00

  • Interrogation of ERG gene rearrangements in prostate cancer identifies a prognostic 10-gene signature with relevant implication to patients' clinical outcome.

    abstract:OBJECTIVES:ERG-gene rearrangement defines a distinct molecular subtype of PCA with potential biological and clinical implications. To identify a molecular signature reflective of the downstream effects of ERG-mediated transcriptional regulation with prognostic implication in patients with prostate cancer (PCA). MATERI...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Bismar TA,Alshalalfa M,Petersen LF,Teng LH,Gerke T,Bakkar A,Al-Mami A,Liu S,Dolph M,Mucci LA,Alhajj R

    更新日期:2014-02-01 00:00:00

  • Robotic partial nephrectomy vs minimally invasive radical nephrectomy for clinical T2a renal mass: a propensity score-matched comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group.

    abstract:OBJECTIVE:To compare outcomes of minimally invasive radical nephrectomy (MIS-RN) and robot-assisted partial nephrectomy (RAPN) in clinical T2a renal mass (cT2aRM). PATIENTS AND METHODS:Retrospective, multicentre, propensity score-matched (PSM) comparison of RAPN and MIS-RN for cT2aRM (T2aN0M0). Cohorts were PSM for ag...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Bradshaw AW,Autorino R,Simone G,Yang B,Uzzo RG,Porpiglia F,Capitanio U,Porter J,Bertolo R,Minervini A,Lau C,Jacobsohn K,Ashrafi A,Eun D,Mottrie A,White WM,Schips L,Challacombe BJ,De Cobelli O,Mir CM,Veccia A,Lar

    更新日期:2020-07-01 00:00:00

  • National bias in citations in urology journals: parochialism or availability?

    abstract:OBJECTIVE:To determine any bias by authors of different nationalities in their citation rate of selected urological journals in papers published in the British Journal of Urology and the Journal of Urology. METHODS:Using a simple computer program and text files of accepted reports in the BJU, or those available on CD-...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Grange RI

    更新日期:1999-10-01 00:00:00