Abstract:
OBJECTIVE:•To determine the relationship between statin use and biochemical recurrence (BCR) following radical prostatectomy (RP). PATIENTS AND METHODS:•A retrospective analysis was performed on 3198 RP patients between 1990 and 2008. •Exclusion criteria were neo-adjuvant or adjuvant therapy, follow-up <2 years, and insufficient pathological or prostate-specific antigen (PSA) data. •Statin use was determined from the patient's record. Clinical and pathological variables were compared between statin users and non-users. •Kaplan-Meier and multivariate Cox regression analyses were performed to determine the effect of statin use on BCR. RESULTS:•A total of 1261 patients fit criteria for analysis. There were 281 (22%) statin users. Mean age was 60 years and median follow-up was 36 months (mean 43 months). •Statin users had a lower median preoperative PSA (6.4) compared with non-users (7.1) (P < 0.05). In all, 80% of statin users had a pathological Gleason sum ≥7 compared with 67% of non-users (P < 0.05). •On multivariate analysis, statin use was an independent predictor of BCR (hazard ratio 1.54, P < 0.05). Statin users had a lower 5-year BCR-free survival compared with non-users (75% vs 84%, P < 0.05). CONCLUSIONS:•Statin users are at an increased risk for BCR following RP. This finding may be due to the reduction in preoperative PSA potentially delaying diagnosis and/or masking aggressive disease. •Further studies are necessary to elucidate the impact of statin medications following prostate cancer therapy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ritch CR,Hruby G,Badani KK,Benson MC,McKiernan JMdoi
10.1111/j.1464-410X.2011.10159.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
E211-6issue
8 Pt 2eissn
1464-4096issn
1464-410Xjournal_volume
108pub_type
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05970.x
更新日期:2006-04-01 00:00:00
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doi:10.1046/j.1464-410x.2000.00597.x
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-02-01 00:00:00
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doi:10.1111/bju.13011
更新日期:2015-12-01 00:00:00
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更新日期:2003-12-01 00:00:00
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doi:10.1111/j.1464-410X.2011.10283.x
更新日期:2012-01-01 00:00:00
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更新日期:2012-02-01 00:00:00
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更新日期:2008-03-01 00:00:00
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更新日期:2008-07-01 00:00:00