Abstract:
UNLABELLED:What's known on the subject? and What does the study add? Sunitinib and sorafenib are orally administered multikinase inhibitors approved for the treatment of advanced RCC. The limited pharmacokinetics data on sunitinib and sorafenib suggest that haemodialysis does not significantly alter plasma concentrations. In this retrospective study we define the safety and efficacy of tyrosine kinase inhibitors in patients with metastatic RCC (mRCC) and end-stage renal disease requiring haemodialysis. Even though the retrospective nature of this survey and the relatively small sample size represent major limitations, these data indicate that treatment with sunitinib and sorafenib in this cohort of patients is feasible with no unexpected toxicity and good efficacy, results similar to those in the general population of patients with mRCC. OBJECTIVE:To investigate the safety and efficacy of tyrosine kinase inhibitors (TKIs) in patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease requiring haemodialysis (HD). PATIENTS AND METHODS:Between July 2006 and December 2010, 24 patients undergoing HD were treated with sunitinib and/or sorafenib for mRCC in 14 Italian institutions. We retrospectively reviewed the medical records of these patients to evaluate the administered doses of TKIs, treatment-related toxicities and the clinical response to therapy. RESULTS:Sunitinib was administered at 50 mg daily for 4-6 weeks in six patients, 37.5 mg daily for 4-6 weeks in seven patients (one patient subsequently increased the dose to 50 mg daily), 25 mg daily for 4-6 weeks in two patients and 12.5 mg daily for 4-6 weeks in one patient. Among the eight patients treated with sorafenib, four patients received 800 mg daily (400 mg every 12 h), three patients 400 mg daily and one patient 200 mg daily with a continuous schedule. The estimated median progression-free and overall survival periods of this cohort of patients were 10.3 months and 22.6 months, respectively. With regard to tolerability and safety, no unexpected adverse events were registered and no grade 4 haematological or non-haematological toxicities were reported. CONCLUSIONS:Sunitinib and sorafenib treatment is not contraindicated in patients with mRCC undergoing HD. The outcome of this patient population is similar to that observed in patients with normal renal function treated with TKIs. These results merit further confirmation by a larger prospective trial.
journal_name
BJU Intjournal_title
BJU internationalauthors
Masini C,Sabbatini R,Porta C,Procopio G,Di Lorenzo G,Onofri A,Buti S,Iacovelli R,Invernizzi R,Moscetti L,Aste MG,Pagano M,Grosso F,Lucia Manenti A,Ortega C,Cosmai L,Del Giovane C,Conte PFdoi
10.1111/j.1464-410X.2012.10946.xsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
692-8issue
5eissn
1464-4096issn
1464-410Xjournal_volume
110pub_type
杂志文章abstract:OBJECTIVE:To determine the prevalence of erectile dysfunction (ED) in a large cohort of Brazilian men who were screened for prostate cancer, and to determine risk factors in this population, as there are large cultural differences among countries in reporting the frequency of ED, and it is likely that the prevalence of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08562.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To determine the incidence of severe pain after ureteric stent removal. To evaluate the efficacy of a single dose of a non-steroidal anti-inflammatory drug (NSAID) in preventing this complication. PATIENTS AND METHODS:A prospective, randomised, double-blind, placebo-controlled trial was performed at our ins...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2012.11214.x
更新日期:2013-01-01 00:00:00
abstract::Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high-throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2004.04869.x
更新日期:2004-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10813.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC). PATIENTS, SUBJECTS AND METHODS:The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC. N-glycan shows reduced levels of high molecular weight ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08163.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To describe and assess the evolution of an enhanced recovery programme (ERP) for open radical cystectomy. PATIENTS AND METHODS:We introduced a mentored ERP for radical cystectomy in January 2011. The programme underwent service evaluation and multiple changes in August 2012 that we define as marginal gains. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12644
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To measure the time and subjective quality of individual steps of robot-assisted radical prostatectomy (RARP), as RARP performed by trainees has recently become the most common technique of RP in the USA, and although outcomes from expert surgeons are reported, limited data are available to document training ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08997.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02033.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To explore the predictors of the quality of marriage of men with prostate cancer, as being diagnosed with prostate cancer affects the quality of life of the man and his partner, and while some aspects are known about the impact of the disease and its treatments on the man's quality of life, less is known abou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06807.x
更新日期:2007-06-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical outcome of extracorporeal shock-wave therapy (ESWT) for patients suffering from chronic pelvic pain syndrome (CPPS). PATIENTS AND METHODS:The study included 34 patients who had had CPPS for >or=3 months, who were investigated in two subsequent studies. ESWT was adm...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07742.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine the level of malondialdehyde (MDA), an indirect indicator of lipid peroxidation-induced injury by reactive oxygen species, in testicular biopsy specimens from infertile patients with and without varicocele. PATIENTS AND METHODS:Levels of MDA were measured in the testicular biopsy specimens from ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00755.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...
journal_title:BJU international
pub_type: 杂志文章,meta分析
doi:10.1111/j.1464-410X.2004.05255.x
更新日期:2005-01-01 00:00:00
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doi:10.1111/bju.12283
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11745.x
更新日期:2013-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06053.x
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05349.x
更新日期:2005-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08661.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To examine whether a history of sexually transmitted infections (STIs) or positive STI serology is associated with prevalent and incident benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)-related outcomes in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. METHODS:Self-...
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更新日期:2014-03-01 00:00:00
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doi:10.1046/j.1464-410x.2003.04060.x
更新日期:2003-02-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-02-01 00:00:00
abstract::Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing p...
journal_title:BJU international
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更新日期:2015-11-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2004-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00268.x
更新日期:1999-11-01 00:00:00
abstract::The immediate objective of phosphodiesterase type 5 (PDE5) inhibitor treatment is to restore the ability of a man to achieve and/or maintain an erection adequate for sexual intercourse. As erectile dysfunction (ED) generally develops in the second half of life, the ultimate objective generally is not procreation, but ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.08267.x
更新日期:2009-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02993.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. PATIENTS AND METHODS:Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tula...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.09042.x
更新日期:2010-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09417.x
更新日期:2010-11-01 00:00:00