Abstract:
:The immediate objective of phosphodiesterase type 5 (PDE5) inhibitor treatment is to restore the ability of a man to achieve and/or maintain an erection adequate for sexual intercourse. As erectile dysfunction (ED) generally develops in the second half of life, the ultimate objective generally is not procreation, but quality of sexual life. Indeed, ED is known to impair quality of life considerably; two-thirds of men report that ED has impaired their self-esteem and nearly a third claim that it has damaged the relationship with their partner. It follows that the therapeutic success of PDE5 inhibition has an important subjective component, which is compounded by the subjective nature and complexity of sexual life in humans. This makes it very difficult for physicians to be certain that they have selected the optimal therapy for a couple, even after a thorough evaluation. The 2007 European Association of Urology Guidelines stress the importance of educating the patient and claim that 'the patient will choose the final drug after his own experience'. However, PDE5 inhibitors are typically used twice a week, so a patient would have to spend approximately 3 months trying the various compounds and dosages to achieve adequate exposure to all three PDE5 inhibitors; this would seem an unrealistic strategy in normal clinical practice. The acknowledgement that the patient has an important role in therapeutic decisions for ED has fuelled interest in the concept of patient preference. It has been established that patient preference depends on three factors, i.e. personal characteristics, e.g. age, duration of ED, frequency and dynamics of sexual relations, and the characteristics of their partners, e.g. age, menopausal status and level of interest in sexual activity and medication profile. Medication features of interest include efficacy in terms of quality of erection, consistency of effects, rapid onset of action, long duration of action, side-effect profile and route of administration; drug costs must also be considered if the medicinal product is not reimbursed.
journal_name
BJU Intjournal_title
BJU internationalauthors
Mirone V,Fusco F,Rossi A,Sicuteri R,Montorsi Fdoi
10.1111/j.1464-410X.2008.08267.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
1212-7issue
9eissn
1464-4096issn
1464-410Xpii
BJU8267journal_volume
103pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the neurophysiological and vascular factors in diabetic impotence, particularly the role of autonomic neuropathy on venous leakage and erectile impotence. PATIENTS AND METHODS:Thirty-four diabetic men with impotence were investigated using various neurophysiological and radiological methods. The...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00916.x
更新日期:1999-03-01 00:00:00
abstract::The first two reviews are from the same unit in Germany and describe the well-known but still much discussed ways of improving the prognosis of patients undergoing cystectomy for bladder cancer. The authors review the roles of lymph node dissection and perioperative chemotherapy, and draw conclusions which will be of ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07114.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14894
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To determine if patients who undergo tubularized incised-plate (TIP) urethroplasty need regular dilatation to prevent neourethral strictures or meatal stenosis. PATIENTS AND METHODS:The follow-up of two consecutive series of patients who underwent primary TIP hypospadias repair by one surgeon was reviewed. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01901.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To examine differences in gene expression levels between renal cell carcinoma (RCC) tissue and 'normal' appearing renal tissue using a commercially available DNA macroarray. MATERIALS AND METHODS:Tissue was obtained from 47 consecutive radical nephrectomies, 29 of which were eligible. DNA macroarrays were an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06209.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To evaluate contrast-enhanced ultrasonography (US) using cadence-contrast pulse sequencing (CPS) technology, compared with systematic biopsy for detecting prostate cancer, as grey-scale US has low sensitivity and specificity for detecting prostate cancer. PATIENTS AND METHODS:In all, 44 men with suspicious p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08038.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term results of salvage cystectomy after interstitial radiotherapy (IRT) and external beam radiotherapy (EBRT) for transitional cell carcinoma, and to assess the morbidity and functional results of the different urinary diversions used. PATIENTS AND METHODS:The records of 27 patients tre...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05034.x
更新日期:2004-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and what does the study add?: Variations in the type of urinary diversion exist for patients undergoing radical cystectomy. Although its use has been increasing from 2001 to 2008, patients who are older, female, and primary insured by Medicaid are less likely to receive continent...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11508.x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To quantify in absolute terms the potential benefit of regionalisation of care from low- to high-volume hospitals. PATIENTS AND METHODS:Patients with a primary diagnosis of bladder cancer treated with radical cystectomy (RC) were identified within the Nationwide Inpatient Sample, a retrospective observationa...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12288
更新日期:2014-05-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: It has been suggested that a very short positive margin does not confer additional risk of BCR after radical prostatectomy. This study shows that even very short PSM is associated with increased risk of BCR. OBJECTIVE:To re-evaluate, in a larger coh...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11340.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To report a national questionnaire survey of all consultant urologists, providing a 'snapshot' of attitudes, current practice and referral patterns for radical prostatectomy (RP) in Britain and Ireland at the millennium. METHODS:During 1999/2000 a simple questionnaire about RP was sent to the 487 urologists ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02906.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To identify, in a retrospective study, possible molecular markers predictive of radioresponsiveness in patients with transitional cell carcinoma (TCC) of the bladder. PATIENTS AND METHODS:Patients with T2-T4a TCC treated with preoperative radiotherapy and cystectomy were included in the study if their cystec...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02268.x
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility and efficacy of suicide-gene therapy using adenovirus (Ad)-mediated herpes simplex virus thymidine kinase (HSV-TK) and the prodrug acyclovir, and to evaluate changes in the biological phenotype for tumour cell proliferative activity after suicide-gene therapy in animal models of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00516.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02243.x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To determine if a decrease in oestrogen (E) levels increases activity in bladder afferent nerves, by investigating the effects of E loss on afferent nerve activity in ovariectomized (OVX) rats, and making comparisons with findings in ageing female rats. MATERIALS AND METHODS:Female Sprague-Dawley rats were d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09689.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:To report the clinical experience with a second-generation of temporary implantable nitinol device (iTIND; Medi-Tate Ltd, Or-Akiva, Israel) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) after 1 year of follow-up. PATIENTS AND METHODS:In all, 81 patients w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/bju.14608
更新日期:2019-06-01 00:00:00
abstract:UNLABELLED:To determine whether dendritic cells (DC) transduced with the prostate-specific antigen (PSA) gene can induce PSA-specific cytotoxic lymphocytes (CTL) against prostate cancer cells, and whether bacillus Calmette-Guérin (BCG) cell-wall skeleton (CWS) can enhance the maturation of DC-PSA and the killing activi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2009.08703.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To evaluate two methods of reducing the urine output during treatment (the most easily manipulated variable) in patients undergoing intravesical instillation with mitomycin C, where the concentration-time curve also depends upon dose, diluent volume, residual urine volume, and drug absorption and degradation....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00869.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To evaluate whether injection with pericapsular lignocaine before transrectal ultrasonography (TRUS)-guided biopsy reduces the perceived pain of prostatic biopsy. PATIENTS AND METHODS:The study included 121 patients referred for TRUS-guided biopsy of the prostate; 27 underwent biopsy with no previous injecti...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
abstract::Tribute to Professor Pieter De Mulder, from Martin Gore. Pieter and I were often pitted against each other in debates at international meetings on the role of cytokine therapy. The truth is that there was little disagreement between us, but we both thought such set pieces were a good way to highlight the issues surrou...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07435.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the justification for operative intervention in patients undergoing surgery for benign scrotal pathology, and to assess the associated morbidity. PATIENTS AND METHODS:Consecutive patients in two surgical firms who underwent surgery for benign intrascrotal pathology over a 5-year period were studi...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2001.02276.x
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06515.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the proportion of patients achieving clinically meaningful improvement of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH-LUTS) with tadalafil using two definitions of response. PATIENTS AND METHODS:Post hoc integrated analysis of four placebo-controlled studies in m...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.12926
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine the role of hypoxia-inducible factor-2alpha (HIF2alpha) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2alpha protein levels. MATERIALS AND METHODS:Cell lines expressing stable short-hairpin ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07558.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:To investigate the correlation of transient receptor potential vanilloid subfamily 1 (TRPV1) mRNA expression levels and the clinical outcome of intravesical resiniferatoxin treatment in patients with idiopathic detrusor overactivity (IDO), as such treatment with vanilloids can be effective for DO. PATIENTS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07151.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, type and treatment behaviour of women with urinary incontinence in four European countries. SUBJECTS AND METHODS:Data were collected using a postal survey which was sent to 29,500 community-dwelling women aged > or = 18 years in France, Germany, Spain and the UK. Subjects were as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2003.04609.x
更新日期:2004-02-01 00:00:00
abstract:UNLABELLED:OBJECTIVE • To determine how the presence of MP on T1 biopsy specimens affects the outcome of patients undergoing RC as compared to when no MP is identified in the TURBT specimen. PATIENTS AND METHODS:• Patients were retrospectively identified from the Columbia University Urologic Oncology Database. • From ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09893.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of renal function on the stone-free rate (SFR) of proximal ureteric stones (PUS) after extracorporeal shock wave lithotripsy (ESWL), as urinary obstruction caused by PUS can impair renal function, and elevated serum creatinine levels are associated with decreased ureteric stone passa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08974.x
更新日期:2010-04-01 00:00:00
abstract::• Synthetic mid-urethral slings (MUSs) are considered the first choice surgical procedure for stress urinary incontinence. Recent publications have raised concerns about the efficacy of third generation single-incision mini-slings. The present paper is a systematic review of studies reporting 12-month outcomes after t...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10333.x
更新日期:2011-09-01 00:00:00