Abstract:
:Chromosome-sized DNA molecules from Trypanosoma cruzi clone Dm 28c were analyzed and compared with other T. cruzi strains and monogenetic trypanosomatids by orthogonal field alteration gel electrophoresis. The results showed that T. cruzi Dm 28c displays at least 18 chromosomes ranging from 550 to more than 1500 kb and that in general the trypanosomatids have smaller chromosomes distributed in the size range from 300 to 1500 kb. With the exception of T. cruzi strain G49, there is no evidence of minichromosomes, suggesting they are not widely distributed among different isolates of the parasite. The hybridization of T. cruzi chromosomal Southern blots with probes for T. cruzi-specific genes showed that their location can change from one strain to another, supporting the idea of the plasticity of the parasite genome. Furthermore, the chromosome pattern is strictly conserved during the transformation of T. cruzi Dm 28c epimastigotes to metacyclic trypomastigotes, suggesting that extensive chromosomal rearrangements do not occur during at least part of the life cycle of the parasite.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Aymerich S,Goldenberg Sdoi
10.1016/0014-4894(89)90178-1subject
Has Abstractpub_date
1989-08-01 00:00:00pages
107-15issue
2eissn
0014-4894issn
1090-2449journal_volume
69pub_type
杂志文章abstract::African trypanosomes exhibit dramatic developmental changes in carbohydrate and energy metabolism, with cytochrome-mediated respiration playing an important role only in the insect stages. The parasites possess three isozymes of malate dehydrogenase, each of which has a different subcellular localization and, likely, ...
journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1998.4260
更新日期:1998-05-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(88)90007-0
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1998.4282
更新日期:1998-07-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2011.09.012
更新日期:2012-01-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1993.1108
更新日期:1993-12-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2009.11.014
更新日期:2010-04-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2005.08.001
更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2007.02.009
更新日期:2007-08-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2008.01.003
更新日期:2008-05-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2018.07.018
更新日期:2018-10-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2006.11.004
更新日期:2007-05-01 00:00:00
abstract::Fasciola hepatica is a digenean trematode which infects a wide variety of domestic animals and also humans. Previous studies have demonstrated that four monoclonal antibodies (Mabs) against the total extract of F. hepatica redia (named as 1E4, 6G11, 4E5 and 4G11) also recognized the excretion - secretion antigens (ES ...
journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2016.06.010
更新日期:2016-09-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2008.07.001
更新日期:2008-10-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(91)90096-f
更新日期:1991-10-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1995.1114
更新日期:1995-11-01 00:00:00
abstract::Leishmaniasis, a neglected tropical disease (NTD) causes major health problems in the tropical and subtropical world. Most of the antileishmanial modern therapies with different formulations of pentavalent antimonials, Miltefosine, Amphotericin B etc. are not satisfactory in recent times due to high toxicity to the ho...
journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2014.08.009
更新日期:2014-11-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00