Abstract:
BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to investigate genetic relationship between the parents and their hybrid progenies. RESULTS:The chromosomal inheritance of diploid and allotetraploid hybrid progenies in successive generations, was studied by applying 5S rDNA fluorescence in situ hybridization. Signals of 5S rDNA distinguished the chromosomal constitution of common carp (B-genome) from red crucian carp (A-genome), in which two strong signals were observed on the first submetacentric chromosome, while no major signal was found in common carp. After fish hybridization, one strong signal of 5S rDNA was detected in the same locus on the chromosome of diploid hybrids. As expected, two strong signals were observed in 4nF3 tetraploid hybrids offspring and it is worth mentioning that two strong signals were detected in a separating bivalent of a primary spermatocyte in 4nF3. Furthermore, the mitosis of heterozygous chromosomes was shown normal and stable with blastular tissue histological studies. CONCLUSIONS:We revealed that 5S rDNA signal can be applied to discern A-genome from B-genome, and that 5S rDNA bearing chromosomes can be stably passed down in successive generations. Our work provided a significant method in fish breeding and this is important for studies in fish evolutionary biology.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu Sdoi
10.1186/s12863-015-0295-8subject
Has Abstractpub_date
2015-12-03 00:00:00pages
140issn
1471-2156pii
10.1186/s12863-015-0295-8journal_volume
16pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:Hybrid breakdown has been well documented in various species. Relationships between genomic heterozygosity and traits-fitness have been extensively explored especially in the natural populations. But correlations between genomic heterozygosity and vegetative and reproductive traits in cotton interspecific po...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0366-5
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS:In 2027 participants rando...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0272-2
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-13
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have only a single copy. DNA sequence comparisons with other rodents with multiple Sry copies are incon...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-11
更新日期:2007-04-04 00:00:00
abstract:BACKGROUND:Linkage disequilibrium (LD) mapping is commonly used to evaluate markers for genome-wide association studies. Most types of LD software focus strictly on LD analysis and visualization, but lack supporting services for genotyping. RESULTS:We developed a freeware called LD2SNPing, which provides a complete pa...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-26
更新日期:2009-06-06 00:00:00
abstract::Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Genetic Analysis Workshop 14 (GAW14) in order to search for genes predisposing to alcohol dependence. Using factor...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S15
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-59
更新日期:2012-07-18 00:00:00
abstract:BACKGROUND:The SnRKs (sucrose non-fermenting 1 related protein kinase) are a gene family coding for Ser/Thr protein kinases and play important roles in linking the tolerance and metabolic responses of plants to abiotic stresses. To date, no genome-wide characterization of the sucrose non-ferment 1 related protein kinas...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0506-6
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current toba...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-78
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. R...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0323-8
更新日期:2016-01-06 00:00:00
abstract:BACKGROUND:Sox domain containing genes are important metazoan transcriptional regulators implicated in a wide rage of developmental processes. The vertebrate B subgroup contains the Sox1, Sox2 and Sox3 genes that have early functions in neural development. Previous studies show that Drosophila Group B genes have been f...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-26
更新日期:2005-05-19 00:00:00
abstract:BACKGROUND:Human glycosylase IV is involved in GLUT2 transporter regulation in pancreatic beta cells. A KO of this gene along with a high fat diet in a mice model has been associated with the development of type 2 diabetes (T2D). The aims of this study were to measure and compare the MGAT4A mRNA levels in white blood c...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-73
更新日期:2007-10-22 00:00:00
abstract:BACKGROUND:Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present st...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0736-x
更新日期:2019-03-26 00:00:00
abstract:BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-17
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0639-2
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have crucial roles in various biological regulatory processes. However, the study of lncRNAs is limited in woody plants. Catalpa bungei is a valuable ornamental tree with a long cultivation history in China, and a deeper understanding of the floral transition mechanism in C. bu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0671-2
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two major challenges arise in haplotype-based association analysis of family data. First, haplotypes may ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00902-x
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our re...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0319-4
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Interleukin-10 and tumor necrosis factor α play an important role in breast carcinogenesis. Genes, encoding those two cytokines, contain single nucleotide polymorphisms, which are associated with differential levels of gene transcription. This study analyzes single nucleotide polymorphisms in interleukin 10 ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0234-8
更新日期:2015-06-26 00:00:00
abstract:BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-73
更新日期:2008-11-18 00:00:00
abstract:BACKGROUND:Relatively little information is available for sequence variation in the pig. We previously used a combination of short read (25 base pair) high-throughput sequencing and reduced genomic representation to discover > 60,000 single nucleotide polymorphisms (SNP) in cattle, but the current lack of complete geno...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-81
更新日期:2008-12-04 00:00:00
abstract:BACKGROUND:The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of the Drosophila CNS is frequently achieved by employing the binary Gal4/UAS system...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00895-7
更新日期:2020-10-22 00:00:00
abstract::We estimated the crossover frequency in 1,232 gametes from 356 subjects in pedigrees from the Collaborative Study on the Genetics on Alcoholism. We examined the effect of covariates including age, ethnicity, and years with ALDX1 on recombination rate, and found a positive correlation between recombination rate and yea...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S58
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a re...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0514-6
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:The disease gene of fragile X syndrome, FMR1 gene, encodes fragile X mental retardation protein (FMRP). The alternative splicing (AS) of FMR1 can affect the structure and function of FMRP. However, the biological functions of alternatively spliced isoforms remain elusive. In a previous study, we identified a...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00870-2
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:Female lions generally do not disperse far beyond their natal range, while males can disperse distances of over 200 km. However, in bush-like ecosystems dispersal distances less than 25 km are reported. Here, we investigate dispersal in lions sampled from the northern and southern extremes of Kruger National...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0607-x
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Fenofibrate (Fb) is a known treatment for elevated triglyceride (TG) levels. The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study was designed to investigate potential contributors to the effects of Fb on TG levels. Here, we summarize the analyses of 8 papers whose authors had access to the GO...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0652-5
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-107
更新日期:2010-12-07 00:00:00
abstract:BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0148-x
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-30
更新日期:2008-04-10 00:00:00