Abstract:
BACKGROUND:In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS:In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six SNPs in MEOX2 and four in TCF15. Over 15.2 years (median), CHD, myocardial infarction, coronary revascularisation and ischaemic cardiomyopathy occurred in 106, 53, 78 and 22 participants. For SNPs, we contrasted CHD risk in minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers (variant) vs. non-carriers. In multivariable-adjusted analyses with correction for multiple testing, CHD risk was associated with MEOX2 SNPs (P ≤ 0.049), but not with TCF15 SNPs (P ≥ 0.29). The MEOX2 GTCCGC haplotype (frequency 16.5 %) was associated with the sex- and age-standardised CHD incidence (5.26 vs. 3.03 events per 1000 person-years; P = 0.036); the multivariable-adjusted hazard ratio [HR] of CHD was 1.78 (95 % confidence interval, 1.25-2.56; P = 0.0054). For myocardial infarction, coronary revascularisation, and ischaemic cardiomyopathy, the corresponding HRs were 1.96 (1.16-3.31), 1.87 (1.20-2.91) and 3.16 (1.41-7.09), respectively. The MEOX2 GTCCGC haplotype significantly improved the prediction of CHD over and beyond traditional risk factors and was associated with similar population-attributable risk as smoking (18.7 % vs. 16.2 %). CONCLUSIONS:Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Yang WY,Petit T,Thijs L,Zhang ZY,Jacobs L,Hara A,Wei FF,Salvi E,Citterio L,Delli Carpini S,Gu YM,Knez J,Cauwenberghs N,Barcella M,Barlassina C,Manunta P,Coppiello G,Aranguren XL,Kuznetsova T,Cusi D,Verhamme P,Ludoi
10.1186/s12863-015-0272-2subject
Has Abstractpub_date
2015-10-01 00:00:00pages
116issn
1471-2156pii
10.1186/s12863-015-0272-2journal_volume
16pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0484-8
更新日期:2017-03-02 00:00:00
abstract:BACKGROUND:Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0177-0
更新日期:2015-02-11 00:00:00
abstract:BACKGROUND:Foxtail millet (Setaria italica) is a diploid C4 panicoid species. Because of its prominent drought resistance, small genome size, self-pollination, and short life cycle, foxtail millet has become an ideal model system for studying drought tolerance of crops. MicroRNAs (miRNAs) are endogenous, small RNAs tha...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0364-7
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present st...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0736-x
更新日期:2019-03-26 00:00:00
abstract::Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S82
更新日期:2003-12-31 00:00:00
abstract::This study, part of the Genetic Analysis Workshop 14 (GAW14), explored real Collaborative Study on the Genetics of Alcoholism data for linkage and association mapping between genetic polymorphisms (microsatellite and single-nucleotide polymorphisms (SNPs)) and beta (16.5-20 Hz) oscillations of the brain rhythms (ecb21...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S94
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00889-5
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Grasslands in the Arctic tundra undergo irreversible degradation due to climatic changes and also over-exploitation and depletion of scarce resources. Comprehensive investigations of cytogenomic structures of valuable Arctic and sub-Arctic grassland species is essential for clarifying their genetic peculiari...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0792-2
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Genetic improvement of beef quality will benefit both producers and consumers, and can be achieved by selecting animals that carry desired quantitative trait nucleotides (QTN), which result from intensive searches using genetic markers. This paper presents a genome-wide association approach utilizing single ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-80
更新日期:2013-09-11 00:00:00
abstract:BACKGROUND:Overexploitation of wildlife populations results in direct consequences, such as extinction and local extirpation, as well as indirect effects including genetic diversity loss and changes in genetic structure. A clear understanding of the underlying genetic patterns of harvested species is necessary for sust...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0188-x
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:Compared to model-based approaches, nonparametric methods for quantitative trait loci mapping are more robust to deviations in distributional assumptions. In this study, we modify a nonparametric regression method and the "contrast function"- based regression method to analyze total cholesterol level in the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S92
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current toba...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-78
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in multiple epithelia during later development. Both insertions caused recessive mutations that r...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0302-0
更新日期:2015-12-18 00:00:00
abstract:BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0673-0
更新日期:2018-09-19 00:00:00
abstract::Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three populations AI, KA, and DA but with large differences in significance levels. These differences in results may be ex...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S140
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Typically, the first phase of a genome wide association study (GWAS) includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide ad...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-94
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:There is increasing evidence that the ability to adapt to seawater in teleost fish is modulated by genetic factors. Most studies have involved the comparison of species or strains and little is known about the genetic architecture of the trait. To address this question, we searched for QTL affecting osmoregu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-46
更新日期:2011-05-14 00:00:00
abstract:BACKGROUND:We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations. RESULTS:Sequence reads from light shot-gun sequencing efforts of different dog breeds were aligned to the dog genome reference sequence and gaps corresponding to indels were identified. One h...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-8
更新日期:2008-01-22 00:00:00
abstract::Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S113
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of the Drosophila CNS is frequently achieved by employing the binary Gal4/UAS system...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00895-7
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Cell motility is an essential feature of the pathogenesis and morbidity of amoebiasis caused by Entamoeba histolytica. As motility depends on cytoskeletal organisation and regulation, a study of the molecular components involved is key to a better understanding of amoebic pathogenesis. However, little is kno...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-28
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:Sesame is an important oil crop in tropical and subtropical areas. Despite its nutritional value and historic and cultural importance, the research on sesame has been scarce, particularly as far as its genetic diversity is concerned. The aims of the present study were to clarify genetic relationships among 3...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-7-10
更新日期:2006-02-16 00:00:00
abstract:BACKGROUND:Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study, we aimed to identify major QTLs for kernel length, as well as putative candidate genes that migh...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0438-6
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a re...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0514-6
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0181-4
更新日期:2015-02-28 00:00:00
abstract:BACKGROUND:Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease. Three in-bred strains of rats, WKY, SHR and SHRSP, are known to be sitosterolemi...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-40
更新日期:2005-07-18 00:00:00
abstract::Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S21
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:The use of pooled DNA on SNP microarrays (SNP-MaP) has been shown to be a cost effective and rapid manner to perform whole-genome association evaluations. While the accuracy of SNP-MaP was extensively evaluated on the early Affymetrix 10 k and 100 k platforms, there have not been as many similarly comprehens...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-82
更新日期:2009-12-14 00:00:00
abstract::The Framingham Heart Study offspring cohort, a complex data set with irregularly spaced longitudinal phenotype data, was made available as part of Genetic Analysis Workshop 13. To allow an analysis of all of the data simultaneously, a mixed-model- based random-regression (RR) approach was used. The RR accounted for th...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S22
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Cigarette smoking behavior may have a genetic basis. We assessed evidence for quantitative trait loci (QTLs) affecting the maximum number of cigarettes smoked per day, a trait meant to quantify this behavior, using data collected over 40 years as part of the Framingham Heart Study's original and offspring co...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S102
更新日期:2003-12-31 00:00:00