Exome scale map of genetic alterations promoting metastasis in colorectal cancer.

abstract：BACKGROUND:Genome-wide association studies involve detecting association between millions of genetic variants and a trait, which typically use univariate regression to test association between each single variant and the phenotype. Alternatively, Lasso penalized regression allows one to jointly model the relationship b...

journal_title：BMC genetics

authors： Arbet J,McGue M,Chatterjee S,Basu S

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously reported that most individuals with CFEOM1 and rare individuals with CFEOM3 harbor heterozygous mutatio...

journal_title：BMC genetics

authors： Chan WM,Andrews C,Dragan L,Fredrick D,Armstrong L,Lyons C,Geraghty MT,Hunter DG,Yazdani A,Traboulsi EI,Pott JW,Gutowski NJ,Ellard S,Young E,Hanisch F,Koc F,Schnall B,Engle EC

更新日期：2007-05-18 00:00:00

abstract：BACKGROUND:Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been reported in the past few years. Most of the quantitative trait loci (QTLs) for GY under drought in rice r...

journal_title：BMC genetics

authors： Vikram P,Swamy BP,Dixit S,Ahmed HU,Teresa Sta Cruz M,Singh AK,Kumar A

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in t...

journal_title：BMC genetics

authors： Martínez-Arzate SG,Sánchez-Bermúdez JC,Sotelo-Gómez S,Diaz-Albiter HM,Hegazy-Hassan W,Tenorio-Borroto E,Barbabosa-Pliego A,Vázquez-Chagoyán JC

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:Cigarette smoking behavior may have a genetic basis. We assessed evidence for quantitative trait loci (QTLs) affecting the maximum number of cigarettes smoked per day, a trait meant to quantify this behavior, using data collected over 40 years as part of the Framingham Heart Study's original and offspring co...

journal_title：BMC genetics

authors： Goode EL,Badzioch MD,Kim H,Gagnon F,Rozek LS,Edwards KL,Jarvik GP,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Despite several thousands of years of close contacts, there are genetic differences between the neighbouring countries of Finland and Sweden. Within Finland, signs of an east-west duality have been observed, whereas the population structure within Sweden has been suggested to be more subtle. With a fine-scal...

journal_title：BMC genetics

authors： Hannelius U,Salmela E,Lappalainen T,Guillot G,Lindgren CM,von Döbeln U,Lahermo P,Kere J

更新日期：2008-08-19 00:00:00

abstract：BACKGROUND:Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on su...

journal_title：BMC genetics

authors： Haase B,Doherr MG,Seuberlich T,Drögemüller C,Dolf G,Nicken P,Schiebel K,Ziegler U,Groschup MH,Zurbriggen A,Leeb T

更新日期：2007-04-16 00:00:00

abstract：BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

journal_title：BMC genetics

authors： Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Genetic markers conferring susceptibility to diabetes specific renal disease remains to be identified for early prediction and development of effective drugs and therapies. Inconsistent results obtained from analysis of genes from classical pathways generate need for examination of unconventional genetic mar...

journal_title：BMC genetics

authors： Prasad P,Kumar KM,Ammini AC,Gupta A,Gupta R,Thelma BK

更新日期：2008-03-22 00:00:00

abstract：BACKGROUND:Foxtail millet (Setaria italica) is a diploid C4 panicoid species. Because of its prominent drought resistance, small genome size, self-pollination, and short life cycle, foxtail millet has become an ideal model system for studying drought tolerance of crops. MicroRNAs (miRNAs) are endogenous, small RNAs tha...

journal_title：BMC genetics

authors： Wang Y,Li L,Tang S,Liu J,Zhang H,Zhi H,Jia G,Diao X

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:DNA methylation is an epigenetic modification that mainly repress expression of genes essential during embryogenesis and development. There are key ATPase-dependent enzymes that read or write DNA methylation to remodel chromatin and regulate gene expression. Structural maintenance of chromosome hinge domain ...

journal_title：BMC genetics

authors： Massah S,Jubene J,Lee FJS,Beischlag TV,Prefontaine GG

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...

journal_title：BMC genetics

authors： Hothorn LA,Libiger O,Gerhard D

更新日期：2012-07-18 00:00:00

abstract：BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...

journal_title：BMC genetics

authors： Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu S

更新日期：2015-12-03 00:00:00

abstract：:A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...

journal_title：BMC genetics

authors： Yang HC,Chang CC,Lin CY,Chen CL,Lin CY,Fann CS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have only a single copy. DNA sequence comparisons with other rodents with multiple Sry copies are incon...

journal_title：BMC genetics

authors： Turner ME,Martin C,Martins AS,Dunmire J,Farkas J,Ely DL,Milsted A

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based association analysis is powerful for detecting untyped causal alleles in linkage-disequilibrium (LD) with neigh...

journal_title：BMC genetics

authors： Yang Y,Li SS,Chien JW,Andriesen J,Zhao LP

更新日期：2008-12-22 00:00:00

abstract：:An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance components-based linkage analysis. On the examined simulated, error-free data...

journal_title：BMC genetics

authors： Göring HH,Williams JT,Dyer TD,Blangero J

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for ...

journal_title：BMC genetics

authors： Jin T,Chen J,Zhu L,Zhao Y,Guo J,Huang Y

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...

journal_title：BMC genetics

authors： Li X,Wang X,Zhu H,Liu C,Zhou X,Zhao B,Duan H,Yang J,Gu G,Zhan Y,Yuan J,Abuduwaili K,Qionglu S

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:Epidemiological studies have indicated that obesity and low high-density lipoprotein (HDL) levels are strong cardiovascular risk factors, and that these traits are inversely correlated. Despite the belief that these traits are correlated in part due to pleiotropy, knowledge on specific genes commonly affecti...

journal_title：BMC genetics

authors： Arya R,Lehman D,Hunt KJ,Schneider J,Almasy L,Blangero J,Stern MP,Duggirala R,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Body size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We per...

journal_title：BMC genetics

authors： An B,Xu L,Xia J,Wang X,Miao J,Chang T,Song M,Ni J,Xu L,Zhang L,Li J,Gao H

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...

journal_title：BMC genetics

authors： Thutkawkorapin J,Picelli S,Kontham V,Liu T,Nilsson D,Lindblom A

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...

journal_title：BMC genetics

authors： Silva NM,Rio J,Currat M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris ...

journal_title：BMC genetics

authors： Anderson MG,Nair KS,Amonoo LA,Mehalow A,Trantow CM,Masli S,John SW

更新日期：2008-04-10 00:00:00

abstract：BACKGROUND:Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) as associated with colorectal cancer (CRC) risk in populations of European descent. However, their utility for predicting risk to CRC in Asians remains unknown. A case-cohort study (random sub-cohort N=1,685) from...

journal_title：BMC genetics

authors： Jung KJ,Won D,Jeon C,Kim S,Kim TI,Jee SH,Beaty TH

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

journal_title：BMC genetics

authors： Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

更新日期：2007-07-28 00:00:00

abstract：BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...

journal_title：BMC genetics

authors： Beltram J,Morton NM,Kunej T,Horvat S

更新日期：2016-06-11 00:00:00

abstract：BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...

journal_title：BMC genetics

authors： Taye M,Kim J,Yoon SH,Lee W,Hanotte O,Dessie T,Kemp S,Mwai OA,Caetano-Anolles K,Cho S,Oh SJ,Lee HK,Kim H

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:Marek's disease (MD) is a highly neoplastic disease primarily affecting chickens, and remains as a chronic infectious disease that threatens the poultry industry. Copy number variation (CNV) has been examined in many species and is recognized as a major source of genetic variation that directly contributes t...

journal_title：BMC genetics

authors： Bai H,He Y,Ding Y,Chu Q,Lian L,Heifetz EM,Yang N,Cheng HH,Zhang H,Chen J,Song J

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00