Abstract:
:Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHUNTER+ software to identify regions that potentially harbor disease loci. For each such region, we estimated the sibling identity-by-descent sharing probability distribution at the putative disease locus. Based on these estimated probabilities, the CSI procedures were employed to further localize the disease loci using the single-nucleotide polymorphism markers, leading to confidence intervals/regions for their locations. For our analysis with the simulated data, we had knowledge of the simulating models at the time we performed the analysis.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Papachristou C,Lin Sdoi
10.1186/1471-2156-6-S1-S21keywords:
subject
Has Abstractpub_date
2005-12-30 00:00:00pages
S21issn
1471-2156pii
1471-2156-6-S1-S21journal_volume
6 Suppl 1pub_type
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