Impact of the diagnosis definition on linkage detection.

abstract：BACKGROUND:Transgenic poplar (Populus × euramericana 'Guariento') plants harboring five exogenous, stress-related genes exhibit increased tolerance to multiple stresses including drought, salt, waterlogging, and insect feeding, but the complex mechanisms underlying stress tolerance in these plants have not been elucida...

journal_title：BMC genetics

authors： Zhang W,Chu Y,Ding C,Zhang B,Huang Q,Hu Z,Huang R,Tian Y,Su X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing. RESULTS:Associations between cognitive ageing and 325 single nucleotide polymorphis...

journal_title：BMC genetics

authors： Harris SE,Fox H,Wright AF,Hayward C,Starr JM,Whalley LJ,Deary IJ

更新日期：2007-07-02 00:00:00

abstract：BACKGROUND:There is increasing evidence that the ability to adapt to seawater in teleost fish is modulated by genetic factors. Most studies have involved the comparison of species or strains and little is known about the genetic architecture of the trait. To address this question, we searched for QTL affecting osmoregu...

journal_title：BMC genetics

authors： Le Bras Y,Dechamp N,Krieg F,Filangi O,Guyomard R,Boussaha M,Bovenhuis H,Pottinger TG,Prunet P,Le Roy P,Quillet E

更新日期：2011-05-14 00:00:00

abstract：:We present a new method for fine-mapping a disease susceptibility locus using a case-control design. The new method, termed the weighted average (WA) statistic, averages the Cochran-Armitage (CA) trend test statistic and the difference between the Hardy-Weinberg disequilibrium test statistic for cases and controls (th...

journal_title：BMC genetics

authors： Song K,Orloff MS,Lu Q,Elston RC

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative de...

journal_title：BMC genetics

authors： Clark L,Wei M,Cattoretti G,Mendelsohn C,Tycko B

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...

journal_title：BMC genetics

authors： Goryca K,Kulecka M,Paziewska A,Dabrowska M,Grzelak M,Skrzypczak M,Ginalski K,Mroz A,Rutkowski A,Paczkowska K,Mikula M,Ostrowski J

更新日期：2018-09-19 00:00:00

abstract：:Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...

journal_title：BMC genetics

authors： Ji F,Lee D,Mendell NR

更新日期：2005-12-30 00:00:00

abstract：:Following publication of the original article [1], the authors reported the need for a more detailed acknowledgement of the source of the samples that were analyzed and their coordinates, which are discussed in the 'Methods' section of the article. This Correction provides an addition to the 'Methods' section, and a s...

journal_title：BMC genetics

authors： Omari S,Kamenir Y,Benichou JIC,Pariente S,Sela H,Perl-Treves R

更新日期：2018-07-12 00:00:00

abstract：:Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...

journal_title：BMC genetics

authors： Heidema AG,Boer JM,Nagelkerke N,Mariman EC,van der A DL,Feskens EJ

更新日期：2006-04-21 00:00:00

abstract：BACKGROUND:Female lions generally do not disperse far beyond their natal range, while males can disperse distances of over 200 km. However, in bush-like ecosystems dispersal distances less than 25 km are reported. Here, we investigate dispersal in lions sampled from the northern and southern extremes of Kruger National...

journal_title：BMC genetics

authors： van Hooft P,Keet DF,Brebner DK,Bastos ADS

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations. RESULTS:Sequence reads from light shot-gun sequencing efforts of different dog breeds were aligned to the dog genome reference sequence and gaps corresponding to indels were identified. One h...

journal_title：BMC genetics

authors： Väli U,Brandström M,Johansson M,Ellegren H

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have only a single copy. DNA sequence comparisons with other rodents with multiple Sry copies are incon...

journal_title：BMC genetics

authors： Turner ME,Martin C,Martins AS,Dunmire J,Farkas J,Ely DL,Milsted A

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Peach [Prunus persica (L.) Batsch] is one of the most economically important fruit crops that, due to its genetic and biological characteristics (small genome size, taxonomic proximity to other important species and short juvenile period), has become a model plant in genomic studies of fruit trees. Our aim w...

journal_title：BMC genetics

authors： Aranzana MJ,Abbassi el-K,Howad W,Arús P

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...

journal_title：BMC genetics

authors： Symonová R,Havelka M,Amemiya CT,Howell WM,Kořínková T,Flajšhans M,Gela D,Ráb P

更新日期：2017-03-02 00:00:00

abstract：BACKGROUND:Yami and Ivatan islanders are Austronesian speakers from Orchid Island and the Batanes archipelago that are located between Taiwan and the Philippines. The paternal genealogies of the Yami tribe from 1962 monograph of Wei and Liu were compared with our dataset of non-recombining Y (NRY) chromosomes from the ...

journal_title：BMC genetics

authors： Loo JH,Trejaut JA,Yen JC,Chen ZS,Lee CL,Lin M

更新日期：2011-01-31 00:00:00

abstract：:Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Genetic Analysis Workshop 14 (GAW14) in order to search for genes predisposing to alcohol dependence. Using factor...

journal_title：BMC genetics

authors： Yu Y,Meng Y,Ma Q,Farrell J,Farrer LA,Wilcox MA

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Late embryogenesis abundant (LEA) proteins are large groups of hydrophilic proteins with major role in drought and other abiotic stresses tolerance in plants. In-depth study and characterization of LEA protein families have been carried out in other plants, but not in upland cotton. The main aim of this rese...

journal_title：BMC genetics

authors： Magwanga RO,Lu P,Kirungu JN,Lu H,Wang X,Cai X,Zhou Z,Zhang Z,Salih H,Wang K,Liu F

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified using limma package in R software. ...

journal_title：BMC genetics

authors： He J,Gao Y,Wu G,Lei X,Zhang Y,Pan W,Yu H

更新日期：2018-07-20 00:00:00

abstract：:Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing data for polygenic models using family data. The imputation schemes take into account familial relationships a...

journal_title：BMC genetics

authors： Fridley B,Rabe K,de Andrade M

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Discerning the traits evolving under neutral conditions from those traits evolving rapidly because of various selection pressures is a great challenge. We propose a new method, composite selection signals (CSS), which unifies the multiple pieces of selection evidence from the rank distribution of its diverse...

journal_title：BMC genetics

authors： Randhawa IA,Khatkar MS,Thomson PC,Raadsma HW

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:In a deep sequencing analysis of small RNAs prepared from a living fossil, the tadpole shrimp Triops cancriformis, a 32-nt small RNA was specifically detected in the adult stage. A nucleotide sequence comparison between the 32-nt small RNA and predicted tRNA sequences in the draft nuclear genomic DNA showed ...

journal_title：BMC genetics

authors： Hirose Y,Ikeda KT,Noro E,Hiraoka K,Tomita M,Kanai A

更新日期：2015-07-14 00:00:00

abstract：:Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...

journal_title：BMC genetics

authors： Jacobs KB,Gray-McGuire C,Cartier KC,Elston RC

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Gene identification and sequence determination are critical requirements for many biological, genomic, and bioinformatic studies. With the advent of next generation sequencing (NGS) technologies, such determinations are predominantly accomplished in silico for organisms for which the genome is known or for w...

journal_title：BMC genetics

authors： Romine NM,Martin RJ,Beetham JK

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...

journal_title：BMC genetics

authors： Silva NM,Rio J,Currat M

更新日期：2017-12-15 00:00:00

abstract：:The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...

journal_title：BMC genetics

authors： Liu X,Jorgenson E,Witte JS

更新日期：2005-12-30 00:00:00

abstract：:Genome read categorization determines the genome of origin for sequence reads from an allopolyploid organism. Different techniques have been used to perform read categorization, mostly based on homoeo-SNPs identified between extant diploid relatives of allopolyploids. We present a novel technique for read categorizati...

journal_title：BMC genetics

authors： Page JT,Udall JA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in ex...

journal_title：BMC genetics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Szmatoła T,Piórkowska K,Bugno-Poniewierska M

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Haematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especiall...

journal_title：BMC genetics

authors： Gong YF,Lu X,Wang ZP,Hu F,Luo YR,Cai SQ,Qi CM,Li S,Niu XY,Qiu XT,Zeng J,Zhang Q

更新日期：2010-06-28 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00