Whole-genome variance components linkage analysis using single-nucleotide polymorphisms versus microsatellites on quantitative traits of derived phenotypes from factor analysis of electroencephalogram waves.

abstract：:Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three populations AI, KA, and DA but with large differences in significance levels. These differences in results may be ex...

journal_title：BMC genetics

authors： Dizier MH,Génin E,Babron MC,Bourgain C

更新日期：2005-12-30 00:00:00

abstract：:The Framingham Heart Study offspring cohort, a complex data set with irregularly spaced longitudinal phenotype data, was made available as part of Genetic Analysis Workshop 13. To allow an analysis of all of the data simultaneously, a mixed-model- based random-regression (RR) approach was used. The RR accounted for th...

journal_title：BMC genetics

authors： Macgregor S,Knott SA,White I,Visscher PM,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...

journal_title：BMC genetics

authors： Sabbagh A,Langaney A,Darlu P,Gérard N,Krishnamoorthy R,Poloni ES

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Several lines of evidence including allozyme analysis, restriction digest patterns and sequencing of mtDNA as well as mini- and micro-satellite allele frequencies indicate that Atlantic salmon (Salmo salar) from North America and Europe are genetically distinct. These observations are supported by karyotype ...

journal_title：BMC genetics

authors： Lubieniecki KP,Jones SL,Davidson EA,Park J,Koop BF,Walker S,Davidson WS

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Genetic improvement of beef quality will benefit both producers and consumers, and can be achieved by selecting animals that carry desired quantitative trait nucleotides (QTN), which result from intensive searches using genetic markers. This paper presents a genome-wide association approach utilizing single ...

journal_title：BMC genetics

authors： Lu D,Sargolzaei M,Kelly M,Vander Voort G,Wang Z,Mandell I,Moore S,Plastow G,Miller SP

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS:In 2027 participants rando...

journal_title：BMC genetics

authors： Yang WY,Petit T,Thijs L,Zhang ZY,Jacobs L,Hara A,Wei FF,Salvi E,Citterio L,Delli Carpini S,Gu YM,Knez J,Cauwenberghs N,Barcella M,Barlassina C,Manunta P,Coppiello G,Aranguren XL,Kuznetsova T,Cusi D,Verhamme P,Lu

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...

journal_title：BMC genetics

authors： Rahmatalla SA,Arends D,Reissmann M,Said Ahmed A,Wimmers K,Reyer H,Brockmann GA

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Genetic markers conferring susceptibility to diabetes specific renal disease remains to be identified for early prediction and development of effective drugs and therapies. Inconsistent results obtained from analysis of genes from classical pathways generate need for examination of unconventional genetic mar...

journal_title：BMC genetics

authors： Prasad P,Kumar KM,Ammini AC,Gupta A,Gupta R,Thelma BK

更新日期：2008-03-22 00:00:00

abstract：BACKGROUND:Field pea (Pisum sativum L.) is among the prominent crops in the world as food and feed. There are relatively few simple sequence repeat (SSR) markers developed from expressed sequence tags (ESTs) in P. sativum. RESULTS:In the present study, 15 new EST-SSR markers were developed from publicly available ESTs...

journal_title：BMC genetics

authors： Teshome A,Bryngelsson T,Dagne K,Geleta M

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least on...

journal_title：BMC genetics

authors： Tortereau F,Sanchez MP,Fève K,Gilbert H,Iannuccelli N,Billon Y,Milan D,Bidanel JP,Riquet J

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:Sugar beet is an obligate outcrossing species. Varieties consist of mixtures of plants from various parental combinations. As the number of informative morphological characteristics is limited, this leads to some problems in variety registration research. RESULTS:We have developed 25 new microsatellite mark...

journal_title：BMC genetics

authors： Smulders MJ,Esselink GD,Everaert I,De Riek J,Vosman B

更新日期：2010-05-18 00:00:00

abstract：BACKGROUND:Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. This study was designed to identify m...

journal_title：BMC genetics

authors： Kim BY,Jin H,Lee YJ,Kang GY,Cho J,Lee YS

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously reported that most individuals with CFEOM1 and rare individuals with CFEOM3 harbor heterozygous mutatio...

journal_title：BMC genetics

authors： Chan WM,Andrews C,Dragan L,Fredrick D,Armstrong L,Lyons C,Geraghty MT,Hunter DG,Yazdani A,Traboulsi EI,Pott JW,Gutowski NJ,Ellard S,Young E,Hanisch F,Koc F,Schnall B,Engle EC

更新日期：2007-05-18 00:00:00

abstract：:The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted ...

journal_title：BMC genetics

authors： Brown WM,Beck SR,Lange EM,Davis CC,Kay CM,Langefeld CD,Rich SS,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Although genome-wide association studies have successfully identified thousands of variants associated to complex traits, these variants only explain a small amount of the entire heritability of the trait. Gene-gene interactions have been proposed as a source to explain a significant percentage of the missin...

journal_title：BMC genetics

authors： Aschard H,Gusev A,Brown R,Pasaniuc B

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported a...

journal_title：BMC genetics

authors： Chen H,Xu J,Zhou Y,Gao Y,Wang G,Xia J,Huen MS,Siok WT,Jiang Y,Tan LH,Sun Y

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Japanese Black cattle are a beef breed whose meat is well known to excel in meat quality, especially in marbling, and whose effective population size is relatively low in Japan. Unlike dairy cattle, the accuracy of genomic evaluation (GE) for carcass traits in beef cattle, including this breed, has been poor...

journal_title：BMC genetics

authors： Ogawa S,Matsuda H,Taniguchi Y,Watanabe T,Nishimura S,Sugimoto Y,Iwaisaki H

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Genome-wide association studies involve detecting association between millions of genetic variants and a trait, which typically use univariate regression to test association between each single variant and the phenotype. Alternatively, Lasso penalized regression allows one to jointly model the relationship b...

journal_title：BMC genetics

authors： Arbet J,McGue M,Chatterjee S,Basu S

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare vascular disorder characterized by a capillary wedge pressure ≤ 15 mmHg and a mean pulmonary arterial pressure ≥ 25 mmHg at rest. PAH can be idiopathic, heritable or associated with other conditions. The aim of this study was to analyze the Endoglin (ENG) gene ...

journal_title：BMC genetics

authors： Pousada G,Baloira A,Fontán D,Núñez M,Valverde D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:Association mapping studies offer great promise to identify polymorphisms associated with phenotypes and for understanding the genetic basis of quantitative trait variation. To date, almost all association mapping studies based on structured plant populations examined the main effects of genetic factors on t...

journal_title：BMC genetics

authors： Saïdou AA,Thuillet AC,Couderc M,Mariac C,Vigouroux Y

更新日期：2014-01-06 00:00:00

abstract：BACKGROUND:Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in multiple epithelia during later development. Both insertions caused recessive mutations that r...

journal_title：BMC genetics

authors： Serth K,Beckers A,Schuster-Gossler K,Pavlova MN,Müller J,Paul MC,Reinhardt R,Gossler A

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. Transcription of SLa is enhanced or suppressed when fish are kept in dark or bright conditions, respectively, indicating SLa's important ro...

journal_title：BMC genetics

authors： Sasano Y,Yoshimura A,Fukamachi S

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been reported in the past few years. Most of the quantitative trait loci (QTLs) for GY under drought in rice r...

journal_title：BMC genetics

authors： Vikram P,Swamy BP,Dixit S,Ahmed HU,Teresa Sta Cruz M,Singh AK,Kumar A

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing. RESULTS:Associations between cognitive ageing and 325 single nucleotide polymorphis...

journal_title：BMC genetics

authors： Harris SE,Fox H,Wright AF,Hayward C,Starr JM,Whalley LJ,Deary IJ

更新日期：2007-07-02 00:00:00

abstract：BACKGROUND:Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine chromosome 14 (BTA14) tog...

journal_title：BMC genetics

authors： Marques E,Schnabel RD,Stothard P,Kolbehdari D,Wang Z,Taylor JF,Moore SS

更新日期：2008-07-08 00:00:00

abstract：BACKGROUND:The Mitotic Exit Network (MEN) proteins - including the protein kinase Cdc15 and the protein phosphatase Cdc14 - are essential for exit from mitosis in Saccharomyces cerevisiae. To identify downstream targets of the MEN, we sought telophase arrest bypassed (tab) mutations that bypassed the essential requirem...

journal_title：BMC genetics

authors： Shou W,Deshaies RJ

更新日期：2002-03-12 00:00:00

abstract：BACKGROUND:DNA methylation is an epigenetic modification that mainly repress expression of genes essential during embryogenesis and development. There are key ATPase-dependent enzymes that read or write DNA methylation to remodel chromatin and regulate gene expression. Structural maintenance of chromosome hinge domain ...

journal_title：BMC genetics

authors： Massah S,Jubene J,Lee FJS,Beischlag TV,Prefontaine GG

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...

journal_title：BMC genetics

authors： Woolley SA,Hayes SE,Shariflou MR,Nicholas FW,Willet CE,O'Rourke BA,Tammen I

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in ex...

journal_title：BMC genetics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Szmatoła T,Piórkowska K,Bugno-Poniewierska M

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris ...

journal_title：BMC genetics

authors： Anderson MG,Nair KS,Amonoo LA,Mehalow A,Trantow CM,Masli S,John SW

更新日期：2008-04-10 00:00:00