Age-stratified heritability estimation in the Framingham Heart Study families.

abstract：BACKGROUND:Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two major challenges arise in haplotype-based association analysis of family data. First, haplotypes may ...

journal_title：BMC genetics

authors： Diao G,Lin DY

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Feed efficiency is one of the major components determining costs of animal production. Residual feed intake (RFI) is defined as the difference between the observed and the expected feed intake given a certain production. Residual feed intake 1 (RFI1) was calculated based on regression of individual daily fee...

journal_title：BMC genetics

authors： Do DN,Ostersen T,Strathe AB,Mark T,Jensen J,Kadarmideen HN

更新日期：2014-02-17 00:00:00

abstract：BACKGROUND:Pest eradication using the Sterile Insect Technique (SIT) involves high-density releases of sterilized males that mate with wild females and ultimately suppress the population. Sterilized females are not required for SIT and their removal or separation from males prior to release remains challenging. In orde...

journal_title：BMC genetics

authors： Choo A,Fung E,Chen IY,Saint R,Crisp P,Baxter SW

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:In humans, muscle-specific nicotinergic acetylcholine receptor (AChR) is a transmembrane protein with five different subunits, coded by CHRNA1, CHRNB, CHRND and CHRNG/CHRNE. The gamma subunit of AChR encoded by CHRNG is expressed during early foetal development, whereas in the adult, the γ subunit is replace...

journal_title：BMC genetics

authors： Kariminejad A,Almadani N,Khoshaeen A,Olsson B,Moslemi AR,Tajsharghi H

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Typically, the first phase of a genome wide association study (GWAS) includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide ad...

journal_title：BMC genetics

authors： Iliadis A,Anastassiou D,Wang X

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:The spotted-wing Drosophila (Drosophila suzukii) is a widespread invasive pest that causes severe economic damage to fruit crops. The early development of D. suzukii is similar to that of other Drosophilids, but the roles of individual genes must be confirmed experimentally. Cellularization genes coordinate ...

journal_title：BMC genetics

authors： Yan Y,Jaffri SA,Schwirz J,Stein C,Schetelig MF

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the association in women is unclear. Since lipid levels vary between the sexes the antioxidant effect of ...

journal_title：BMC genetics

authors： Lawlor DA,Day IN,Gaunt TR,Hinks LJ,Briggs PJ,Kiessling M,Timpson N,Smith GD,Ebrahim S

更新日期：2004-06-23 00:00:00

abstract：:Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...

journal_title：BMC genetics

authors： Heidema AG,Boer JM,Nagelkerke N,Mariman EC,van der A DL,Feskens EJ

更新日期：2006-04-21 00:00:00

abstract：BACKGROUND:Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in ex...

journal_title：BMC genetics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Szmatoła T,Piórkowska K,Bugno-Poniewierska M

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in t...

journal_title：BMC genetics

authors： Martínez-Arzate SG,Sánchez-Bermúdez JC,Sotelo-Gómez S,Diaz-Albiter HM,Hegazy-Hassan W,Tenorio-Borroto E,Barbabosa-Pliego A,Vázquez-Chagoyán JC

更新日期：2019-07-12 00:00:00

abstract：:Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...

journal_title：BMC genetics

authors： Ji F,Lee D,Mendell NR

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The Glued gene of Drosophila melanogaster encodes the homologue of the vertebrate p150Glued subunit of dynactin. The Glued1 mutation compromises the dynein-dynactin retrograde motor complex and causes disruptions to the adult eye and the CNS, including sensory neurons and the formation of the giant fiber sys...

journal_title：BMC genetics

authors： Ma L,Johns LA,Allen MJ

更新日期：2009-11-30 00:00:00

abstract：BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...

journal_title：BMC genetics

authors： Sabbagh A,Langaney A,Darlu P,Gérard N,Krishnamoorthy R,Poloni ES

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Growth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accurate prediction of breeding values of animals without own phenotypic information. This study investiga...

journal_title：BMC genetics

authors： Liu T,Qu H,Luo C,Shu D,Wang J,Lund MS,Su G

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

journal_title：BMC genetics

authors： Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

更新日期：2007-07-28 00:00:00

abstract：BACKGROUND:The high mobility group A1 proteins (HMGA1a/HMGA1b) are highly conserved between mammalian species and widely described as participating in various cellular processes. By inducing DNA conformation changes the HMGA1 proteins indirectly influence the binding of various transcription factors and therefore effec...

journal_title：BMC genetics

authors： Beuing C,Soller JT,Muth M,Wagner S,Dolf G,Schelling C,Richter A,Willenbrock S,Reimann-Berg N,Winkler S,Nolte I,Bullerdiek J,Murua Escobar H

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasing over the past few ...

journal_title：BMC genetics

authors： Gajaweera C,Kang JM,Lee DH,Lee SH,Kim YK,Wijayananda HI,Kim JJ,Ha JH,Choi BH,Lee SH

更新日期：2019-08-05 00:00:00

abstract：:Following publication of the original article [1], the authors reported the need for a more detailed acknowledgement of the source of the samples that were analyzed and their coordinates, which are discussed in the 'Methods' section of the article. This Correction provides an addition to the 'Methods' section, and a s...

journal_title：BMC genetics

authors： Omari S,Kamenir Y,Benichou JIC,Pariente S,Sela H,Perl-Treves R

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have crucial roles in various biological regulatory processes. However, the study of lncRNAs is limited in woody plants. Catalpa bungei is a valuable ornamental tree with a long cultivation history in China, and a deeper understanding of the floral transition mechanism in C. bu...

journal_title：BMC genetics

authors： Wang Z,Zhu T,Ma W,Wang N,Qu G,Zhang S,Wang J

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Gene identification and sequence determination are critical requirements for many biological, genomic, and bioinformatic studies. With the advent of next generation sequencing (NGS) technologies, such determinations are predominantly accomplished in silico for organisms for which the genome is known or for w...

journal_title：BMC genetics

authors： Romine NM,Martin RJ,Beetham JK

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...

journal_title：BMC genetics

authors： Silva NM,Rio J,Currat M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity detected in our sample. We performed a mutation screen in 93 extremely obese children and adolescents...

journal_title：BMC genetics

authors： Friedel S,Reichwald K,Scherag A,Brumm H,Wermter AK,Fries HR,Koberwitz K,Wabitsch M,Meitinger T,Platzer M,Biebermann H,Hinney A,Hebebrand J

更新日期：2007-05-03 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi) in normal female cells, leaving them with a single active X (Xa) as in male cells. In cells wit...

journal_title：BMC genetics

authors： Gartler SM,Varadarajan KR,Luo P,Norwood TH,Canfield TK,Hansen RS

更新日期：2006-07-03 00:00:00

abstract：:A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...

journal_title：BMC genetics

authors： Lemire M

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified using limma package in R software. ...

journal_title：BMC genetics

authors： He J,Gao Y,Wu G,Lei X,Zhang Y,Pan W,Yu H

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...

journal_title：BMC genetics

authors： Beltram J,Morton NM,Kunej T,Horvat S

更新日期：2016-06-11 00:00:00

abstract：BACKGROUND:Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual's susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder c...

journal_title：BMC genetics

authors： Hou J,Gu Y,Hou W,Wu S,Lou Y,Yang W,Zhu L,Hu Y,Sun M,Xue H

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and their target binding sites affect miRNA function and are involved in biological processes and diseases, including bovine mastitis, a frequent inflammatory disease. Our previous study has shown that bta-miR-2899 is significantly upregulated in t...

journal_title：BMC genetics

authors： Jiang Q,Zhao H,Li R,Zhang Y,Liu Y,Wang J,Wang X,Ju Z,Liu W,Hou M,Huang J

更新日期：2019-05-16 00:00:00