Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury.

abstract：BACKGROUND:Peach [Prunus persica (L.) Batsch] is one of the most economically important fruit crops that, due to its genetic and biological characteristics (small genome size, taxonomic proximity to other important species and short juvenile period), has become a model plant in genomic studies of fruit trees. Our aim w...

journal_title：BMC genetics

authors： Aranzana MJ,Abbassi el-K,Howad W,Arús P

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo)...

journal_title：BMC genetics

authors： Cheong HS,Yoon DH,Park BL,Kim LH,Bae JS,Namgoong S,Lee HW,Han CS,Kim JO,Cheong IC,Shin HD

更新日期：2008-04-19 00:00:00

abstract：BACKGROUND:Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection agains...

journal_title：BMC genetics

authors： Lewis TW,Blott SC,Woolliams JA

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...

journal_title：BMC genetics

authors： Fernández AI,Muñoz M,Alves E,Folch JM,Noguera JL,Enciso MP,Rodríguez Mdel C,Silió L

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) as associated with colorectal cancer (CRC) risk in populations of European descent. However, their utility for predicting risk to CRC in Asians remains unknown. A case-cohort study (random sub-cohort N=1,685) from...

journal_title：BMC genetics

authors： Jung KJ,Won D,Jeon C,Kim S,Kim TI,Jee SH,Beaty TH

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...

journal_title：BMC genetics

authors： Hothorn LA,Libiger O,Gerhard D

更新日期：2012-07-18 00:00:00

abstract：BACKGROUND:Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. Oculocutaneous albinism was studied in a herd of Murrah buffalo to determine the clinical presentation and genetic basis of albinism in this species. RESULTS:Clinical e...

journal_title：BMC genetics

authors： Damé MC,Xavier GM,Oliveira-Filho JP,Borges AS,Oliveira HN,Riet-Correa F,Schild AL

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine NPY gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The obje...

journal_title：BMC genetics

authors： Bahar B,Sweeney T

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS:Published clinical tr...

journal_title：BMC genetics

authors： Wu J,Province MA,Coon H,Hunt SC,Eckfeldt JH,Arnett DK,Heiss G,Lewis CE,Ellison RC,Rao DC,Rice T,Kraja AT

更新日期：2007-09-10 00:00:00

abstract：BACKGROUND:Genome-wide investigation of molecular mechanisms for high-altitude adaptation has attracted great attention in the last few years. In order to understand the contribution of gene expression level variations to high-altitude adaptation in Asiatic toads (Bufo gargarizans), we implemented a reciprocal transpla...

journal_title：BMC genetics

authors： Yang W,Qi Y,Lu B,Qiao L,Wu Y,Fu J

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

journal_title：BMC genetics

authors： Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Sox domain containing genes are important metazoan transcriptional regulators implicated in a wide rage of developmental processes. The vertebrate B subgroup contains the Sox1, Sox2 and Sox3 genes that have early functions in neural development. Previous studies show that Drosophila Group B genes have been f...

journal_title：BMC genetics

authors： McKimmie C,Woerfel G,Russell S

更新日期：2005-05-19 00:00:00

abstract：BACKGROUND:The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a re...

journal_title：BMC genetics

authors： Hernández CL,Dugoujon JM,Novelletto A,Rodríguez JN,Cuesta P,Calderón R

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...

journal_title：BMC genetics

authors： Huang XQ,Cloutier S

更新日期：2007-05-04 00:00:00

abstract：BACKGROUND:The current genetic structure of Iberian populations has presumably been affected by the complex orography of its territory, the different people and civilizations that settled there, its ancient and complex history, the diverse and persistent sociocultural patterns in its different regions, and also by the ...

journal_title：BMC genetics

authors： Calderón R,Lodeiro R,Varela TA,Fariña J,Ambrosio B,Guitard E,González-Martín A,Dugoujon JM

更新日期：2007-06-27 00:00:00

abstract：BACKGROUND:Relationships between individuals and inbreeding coefficients are commonly used for breeding decisions, but may be affected by the type of data used for their estimation. The proportion of variants with low Minor Allele Frequency (MAF) is larger in whole genome sequence (WGS) data compared to Single Nucleoti...

journal_title：BMC genetics

authors： Eynard SE,Windig JJ,Leroy G,van Binsbergen R,Calus MP

更新日期：2015-03-12 00:00:00

abstract：BACKGROUND:The human Prader-Willi syndrome (PWS) domain and its mouse orthologue include a cluster of paternally expressed genes which imprinted expression is co-ordinately regulated by an imprinting center (IC) closely associated to the Snurf-Snrpn gene. Besides their co-regulated imprinted expression, two observation...

journal_title：BMC genetics

authors： Watrin F,Le Meur E,Roeckel N,Ripoche MA,Dandolo L,Muscatelli F

更新日期：2005-01-05 00:00:00

abstract：BACKGROUND:Cytoplasmic effects on agronomic traits--involving cytoplasmic and nuclear genomes of either different species or different cultivars--are well documented in wheat but have seldom been demonstrated in rice (Oryza sativa L.). To detect cytoplasmic effects, we introgressed the nuclear genomes of three indica c...

journal_title：BMC genetics

authors： Tao D,Xu P,Zhou J,Deng X,Li J,Deng W,Yang J,Yang G,Li Q,Hu F

更新日期：2011-06-01 00:00:00

abstract：:A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...

journal_title：BMC genetics

authors： Lemire M

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:In this article, I propose a model-selection-free method to map multiple quantitative trait loci (QTL) in variance component model, which is useful in outbred populations. The new method can estimate the variance of zero-effect QTL infinitely to zero, but nearly unbiased for non-zero-effect QTL. It is analog...

journal_title：BMC genetics

authors： Fang M

更新日期：2010-04-29 00:00:00

abstract：BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...

journal_title：BMC genetics

authors： Biscarini F,Stevanato P,Broccanello C,Stella A,Saccomani M

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Drought is one of the most important abiotic stresses that cause drastic reduction in rice grain yield (GY) in rainfed environments. The identification and introgression of QTL leading to high GY under drought have been advocated to be the preferred breeding strategy to improve drought tolerance of popular r...

journal_title：BMC genetics

authors： Sandhu N,Singh A,Dixit S,Sta Cruz MT,Maturan PC,Jain RK,Kumar A

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Phenotype error causes reduction in power to detect genetic association. We present a quantification of phenotype error, also known as diagnostic error, on power and sample size calculations for case-control genetic association studies between a marker locus and a disease phenotype. We consider the classic P...

journal_title：BMC genetics

authors： Edwards BJ,Haynes C,Levenstien MA,Finch SJ,Gordon D

更新日期：2005-04-08 00:00:00

abstract：BACKGROUND:The Africanized honey bee is one of the most spectacular invasions in the Americas. African bees escaped from apiaries in Brazil in 1956, spread over Americas and by 1994 they were reported in Puerto Rico. In contrast to other places, the oceanic island conditions in Puerto Rico may mean a single introductio...

journal_title：BMC genetics

authors： Galindo-Cardona A,Acevedo-Gonzalez JP,Rivera-Marchand B,Giray T

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Our initial genome-wide association study (GWAS) identified 20 promising candidate genes for milk fatty acid (FA) traits in a Chinese Holstein population, including PRLR, MOGAT1, MINPP1 and CHUK genes. In this study, we performed whether they had significant genetic effects on milk FA traits in Chinese Holst...

journal_title：BMC genetics

authors： Shi L,Liu L,Lv X,Ma Z,Yang Y,Li Y,Zhao F,Sun D,Han B

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:RNA sequencing (RNA-seq) technology has identified multiple differentially expressed (DE) genes associated to complex disease, however, these genes only explain a modest part of variance. Omnigenic model assumes that disease may be driven by genes with indirect relevance to disease and be propagated by funct...

journal_title：BMC genetics

authors： Shao F,Wang Y,Zhao Y,Yang S

更新日期：2019-03-19 00:00:00

abstract：BACKGROUND:Genetic markers conferring susceptibility to diabetes specific renal disease remains to be identified for early prediction and development of effective drugs and therapies. Inconsistent results obtained from analysis of genes from classical pathways generate need for examination of unconventional genetic mar...

journal_title：BMC genetics

authors： Prasad P,Kumar KM,Ammini AC,Gupta A,Gupta R,Thelma BK

更新日期：2008-03-22 00:00:00

abstract：BACKGROUND:Two key questions in understanding the genetic control of behaviors are: what genes are involved and how these genes interact. To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. RESULTS:We studied 69 genes whose ...

journal_title：BMC genetics

authors： Aleman-Meza B,Loeza-Cabrera M,Peña-Ramos O,Stern M,Zhong W

更新日期：2017-05-12 00:00:00

abstract：:Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three populations AI, KA, and DA but with large differences in significance levels. These differences in results may be ex...

journal_title：BMC genetics

authors： Dizier MH,Génin E,Babron MC,Bourgain C

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00