Abstract:
BACKGROUND:In this article, I propose a model-selection-free method to map multiple quantitative trait loci (QTL) in variance component model, which is useful in outbred populations. The new method can estimate the variance of zero-effect QTL infinitely to zero, but nearly unbiased for non-zero-effect QTL. It is analogous to Xu's Bayesian shrinkage estimation method, but his method is based on allelic substitution model, while the new method is based on the variance component models. RESULTS:Extensive simulation experiments were conducted to investigate the performance of the proposed method. The results showed that the proposed method was efficient in mapping multiple QTL simultaneously, and moreover it was more competitive than the reversible jump MCMC (RJMCMC) method and may even out-perform it. CONCLUSIONS:The newly developed Bayesian shrinkage method is very efficient and powerful for mapping multiple QTL in outbred populations.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Fang Mdoi
10.1186/1471-2156-11-30subject
Has Abstractpub_date
2010-04-29 00:00:00pages
30issn
1471-2156pii
1471-2156-11-30journal_volume
11pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract::The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S104
更新日期:2005-12-30 00:00:00
abstract::The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S12
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Epidemiological studies have indicated that obesity and low high-density lipoprotein (HDL) levels are strong cardiovascular risk factors, and that these traits are inversely correlated. Despite the belief that these traits are correlated in part due to pleiotropy, knowledge on specific genes commonly affecti...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S52
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:In a deep sequencing analysis of small RNAs prepared from a living fossil, the tadpole shrimp Triops cancriformis, a 32-nt small RNA was specifically detected in the adult stage. A nucleotide sequence comparison between the 32-nt small RNA and predicted tRNA sequences in the draft nuclear genomic DNA showed ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0245-5
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:We analyzed 143 pedigrees (364 nuclear families) in the Collaborative Study on the Genetics of Alcoholism (COGA) data provided to the participants in the Genetic Analysis Workshop 14 (GAW14) with the goal of comparing results obtained from genome linkage analysis using microsatellite and with results obtaine...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S4
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:mRNA expression in a cell or subcellular organelle is precisely regulated for the purpose of gene function regulation. The 3' untranslated region (3'UTR) of mRNA is the binding target of microRNA and RNA binding proteins. Their interactions regulate mRNA level in specific subcellular regions and determine th...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0417-y
更新日期:2016-07-29 00:00:00
abstract:BACKGROUND:Anopheles gambiae females are the world's most successful vectors of human malaria. However, a fraction of these mosquitoes is refractory to Plasmodium development. L3-5, a laboratory selected refractory strain, encapsulates transforming ookinetes/early oocysts of a wide variety of Plasmodium species. Previo...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-16
更新日期:2003-10-24 00:00:00
abstract:BACKGROUND:Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from unphased ge...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-5-22
更新日期:2004-08-03 00:00:00
abstract:BACKGROUND:Genetic maps characterizing the inheritance patterns of traits and markers have been developed for a wide range of species and used to study questions in biomedicine, agriculture, ecology and evolutionary biology. The status of rainbow trout genetic maps has progressed significantly over the last decade due ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-74
更新日期:2008-11-19 00:00:00
abstract:BACKGROUND:Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. This study was designed to identify m...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0338-9
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:Alcoholism is a serious public health problem. It has both genetic and environmental causes. In an effort to gain understanding of the underlying genetic susceptibility to alcoholism, a long-term study has been undertaken. The Collaborative Study on the Genetics of Alcoholism (COGA) provides a rich source of...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S131
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:In humans, muscle-specific nicotinergic acetylcholine receptor (AChR) is a transmembrane protein with five different subunits, coded by CHRNA1, CHRNB, CHRND and CHRNG/CHRNE. The gamma subunit of AChR encoded by CHRNG is expressed during early foetal development, whereas in the adult, the γ subunit is replace...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0382-5
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:The extent of linkage disequilibrium (LD) is of critical importance for genomic selection and marker assisted selection. The primary purpose of this study is to examine patterns of LD in three Danish pig breeds (Duroc, Landrace and Yorkshire); we also examine patterns of persistence of phase between the bree...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-115
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:Population stratification can cause spurious associations in a genome-wide association study (GWAS), and occurs when differences in allele frequencies of single nucleotide polymorphisms (SNPs) are due to ancestral differences between cases and controls rather than the trait of interest. Principal components ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-108
更新日期:2010-12-09 00:00:00
abstract:BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-107
更新日期:2010-12-07 00:00:00
abstract:BACKGROUND:Late embryogenesis abundant (LEA) proteins are large groups of hydrophilic proteins with major role in drought and other abiotic stresses tolerance in plants. In-depth study and characterization of LEA protein families have been carried out in other plants, but not in upland cotton. The main aim of this rese...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0596-1
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, from national newborn screening programs may provide a DNA source for entire populations. Combined ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-58
更新日期:2011-07-04 00:00:00
abstract:BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0575-6
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:Cell motility is an essential feature of the pathogenesis and morbidity of amoebiasis caused by Entamoeba histolytica. As motility depends on cytoskeletal organisation and regulation, a study of the molecular components involved is key to a better understanding of amoebic pathogenesis. However, little is kno...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-28
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have crucial roles in various biological regulatory processes. However, the study of lncRNAs is limited in woody plants. Catalpa bungei is a valuable ornamental tree with a long cultivation history in China, and a deeper understanding of the floral transition mechanism in C. bu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0671-2
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Gene identification and sequence determination are critical requirements for many biological, genomic, and bioinformatic studies. With the advent of next generation sequencing (NGS) technologies, such determinations are predominantly accomplished in silico for organisms for which the genome is known or for w...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-55
更新日期:2013-06-18 00:00:00
abstract:BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-13
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0553-z
更新日期:2017-10-23 00:00:00
abstract::Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S113
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-18
更新日期:2007-05-04 00:00:00
abstract::A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S159
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-8
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00889-5
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Overexploitation of wildlife populations results in direct consequences, such as extinction and local extirpation, as well as indirect effects including genetic diversity loss and changes in genetic structure. A clear understanding of the underlying genetic patterns of harvested species is necessary for sust...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0188-x
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage of this approach is that...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-80
更新日期:2010-09-09 00:00:00