Genetic structure of the gentle Africanized honey bee population (gAHB) in Puerto Rico.

abstract：BACKGROUND:Sox domain containing genes are important metazoan transcriptional regulators implicated in a wide rage of developmental processes. The vertebrate B subgroup contains the Sox1, Sox2 and Sox3 genes that have early functions in neural development. Previous studies show that Drosophila Group B genes have been f...

journal_title：BMC genetics

authors： McKimmie C,Woerfel G,Russell S

更新日期：2005-05-19 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...

journal_title：BMC genetics

authors： Sabbagh A,Langaney A,Darlu P,Gérard N,Krishnamoorthy R,Poloni ES

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Intronic DNA sequences of the canine arrestin (SAG) gene was screened to identify potential disease causing mutations in dogs with generalized progressive retinal atrophy (gPRA). The intronic sequences flanking each of the 16 exons were obtained from clones of a canine genomic library. RESULTS:Using polymer...

journal_title：BMC genetics

authors： Dekomien G,Epplen JT

更新日期：2002-07-17 00:00:00

abstract：:The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted ...

journal_title：BMC genetics

authors： Brown WM,Beck SR,Lange EM,Davis CC,Kay CM,Langefeld CD,Rich SS,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Our initial genome-wide association study (GWAS) identified 20 promising candidate genes for milk fatty acid (FA) traits in a Chinese Holstein population, including PRLR, MOGAT1, MINPP1 and CHUK genes. In this study, we performed whether they had significant genetic effects on milk FA traits in Chinese Holst...

journal_title：BMC genetics

authors： Shi L,Liu L,Lv X,Ma Z,Yang Y,Li Y,Zhao F,Sun D,Han B

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine NPY gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The obje...

journal_title：BMC genetics

authors： Bahar B,Sweeney T

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with th...

journal_title：BMC genetics

authors： Velie BD,Fegraeus KJ,Solé M,Rosengren MK,Røed KH,Ihler CF,Strand E,Lindgren G

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:The human Prader-Willi syndrome (PWS) domain and its mouse orthologue include a cluster of paternally expressed genes which imprinted expression is co-ordinately regulated by an imprinting center (IC) closely associated to the Snurf-Snrpn gene. Besides their co-regulated imprinted expression, two observation...

journal_title：BMC genetics

authors： Watrin F,Le Meur E,Roeckel N,Ripoche MA,Dandolo L,Muscatelli F

更新日期：2005-01-05 00:00:00

abstract：BACKGROUND:Genome-wide association studies involve detecting association between millions of genetic variants and a trait, which typically use univariate regression to test association between each single variant and the phenotype. Alternatively, Lasso penalized regression allows one to jointly model the relationship b...

journal_title：BMC genetics

authors： Arbet J,McGue M,Chatterjee S,Basu S

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Genetic maps characterizing the inheritance patterns of traits and markers have been developed for a wide range of species and used to study questions in biomedicine, agriculture, ecology and evolutionary biology. The status of rainbow trout genetic maps has progressed significantly over the last decade due ...

journal_title：BMC genetics

authors： Rexroad CE 3rd,Palti Y,Gahr SA,Vallejo RL

更新日期：2008-11-19 00:00:00

abstract：BACKGROUND:Genetic maps based on single-nucleotide polymorphisms (SNP) are increasingly being used as an alternative to microsatellite maps. This study compares linkage results for both types of maps for a neurophysiology phenotype and for an alcohol dependence phenotype. Our analysis used two SNP maps on the Illumina ...

journal_title：BMC genetics

authors： Dunn G,Hinrichs AL,Bertelsen S,Jin CH,Kauwe JS,Suarez BK,Bierut LJ

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Structured association mapping is proving to be a powerful strategy to find genetic polymorphisms associated with disease. However, these algorithms are often distributed as command line implementations that require expertise and effort to customize and put into practice. Because of the difficulty required t...

journal_title：BMC genetics

authors： Curtis RE,Goyal A,Xing EP

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:Cymbidium is a genus of 68 species in the orchid family, with extremely high ornamental value. Marker-assisted selection has proven to be an effective strategy in accelerating plant breeding for many plant species. Analysis of cymbidiums genetic background by molecular markers can be of great value in assist...

journal_title：BMC genetics

authors： Li X,Jin F,Jin L,Jackson A,Huang C,Li K,Shu X

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:The extent of linkage disequilibrium (LD) is of critical importance for genomic selection and marker assisted selection. The primary purpose of this study is to examine patterns of LD in three Danish pig breeds (Duroc, Landrace and Yorkshire); we also examine patterns of persistence of phase between the bree...

journal_title：BMC genetics

authors： Wang L,Sørensen P,Janss L,Ostersen T,Edwards D

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome. RESULTS:We isolated 11 lethal lines that map...

journal_title：BMC genetics

authors： Boles MK,Wilkinson BM,Maxwell A,Lai L,Mills AA,Nishijima I,Salinger AP,Moskowitz I,Hirschi KK,Liu B,Bradley A,Justice MJ

更新日期：2009-03-06 00:00:00

abstract：:Participants in the family-based analysis group at Genetic Analysis Workshop 19 addressed diverse topics, all of which used the family data. Topics addressed included questions of study design and data quality control (QC), genotype imputation to augment available sequence data, and linkage and/or association analyses...

journal_title：BMC genetics

authors： Wijsman EM

更新日期：2016-02-03 00:00:00

abstract：:The Framingham Heart Study offspring cohort, a complex data set with irregularly spaced longitudinal phenotype data, was made available as part of Genetic Analysis Workshop 13. To allow an analysis of all of the data simultaneously, a mixed-model- based random-regression (RR) approach was used. The RR accounted for th...

journal_title：BMC genetics

authors： Macgregor S,Knott SA,White I,Visscher PM,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Body size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We per...

journal_title：BMC genetics

authors： An B,Xu L,Xia J,Wang X,Miao J,Chang T,Song M,Ni J,Xu L,Zhang L,Li J,Gao H

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for ...

journal_title：BMC genetics

authors： Jin T,Chen J,Zhu L,Zhao Y,Guo J,Huang Y

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations. RESULTS:Sequence reads from light shot-gun sequencing efforts of different dog breeds were aligned to the dog genome reference sequence and gaps corresponding to indels were identified. One h...

journal_title：BMC genetics

authors： Väli U,Brandström M,Johansson M,Ellegren H

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

journal_title：BMC genetics

authors： Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...

journal_title：BMC genetics

authors： Divers J,Redden DT,Rice KM,Vaughan LK,Padilla MA,Allison DB,Bluemke DA,Young HJ,Arnett DK

更新日期：2011-03-04 00:00:00

abstract：BACKGROUND:Many QTL studies have two common features: (1) often there is missing marker information, (2) among many markers involved in the biological process only a few are causal. In statistics, the second issue falls under the headings "sparsity" and "causal inference". The goal of this work is to develop a two-step...

journal_title：BMC genetics

authors： Demetrashvili N,Van den Heuvel ER,Wit EC

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:Retinal function is ordered by interactions between transcriptional and posttranscriptional regulators at the molecular level. These regulators include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs). Some studies propose that miRs predominantly target the TFs rather than...

journal_title：BMC genetics

authors： Andreeva K,Soliman MM,Cooper NG

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Epidemiological studies have indicated that obesity and low high-density lipoprotein (HDL) levels are strong cardiovascular risk factors, and that these traits are inversely correlated. Despite the belief that these traits are correlated in part due to pleiotropy, knowledge on specific genes commonly affecti...

journal_title：BMC genetics

authors： Arya R,Lehman D,Hunt KJ,Schneider J,Almasy L,Blangero J,Stern MP,Duggirala R,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:RNA sequencing (RNA-seq) technology has identified multiple differentially expressed (DE) genes associated to complex disease, however, these genes only explain a modest part of variance. Omnigenic model assumes that disease may be driven by genes with indirect relevance to disease and be propagated by funct...

journal_title：BMC genetics

authors： Shao F,Wang Y,Zhao Y,Yang S

更新日期：2019-03-19 00:00:00

abstract：:The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study this question, two types of covariate models were used in the simulated Genetic Analysis Workshop 14 dataset i...

journal_title：BMC genetics

authors： Bailey JN

更新日期：2005-12-30 00:00:00