Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures.

abstract：BACKGROUND:Compared to model-based approaches, nonparametric methods for quantitative trait loci mapping are more robust to deviations in distributional assumptions. In this study, we modify a nonparametric regression method and the "contrast function"- based regression method to analyze total cholesterol level in the ...

journal_title：BMC genetics

authors： Ghosh S,Bertelsen S,Reich T

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...

journal_title：BMC genetics

authors： Beltram J,Morton NM,Kunej T,Horvat S

更新日期：2016-06-11 00:00:00

abstract：BACKGROUND:Major population movements, social structure, and caste endogamy have influenced the genetic structure of Indian populations. An understanding of these influences is increasingly important as gene mapping and case-control studies are initiated in South Indian populations. RESULTS:We report new data on 155 i...

journal_title：BMC genetics

authors： Watkins WS,Thara R,Mowry BJ,Zhang Y,Witherspoon DJ,Tolpinrud W,Bamshad MJ,Tirupati S,Padmavati R,Smith H,Nancarrow D,Filippich C,Jorde LB

更新日期：2008-12-12 00:00:00

abstract：BACKGROUND:Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confu...

journal_title：BMC genetics

authors： Wang T,Zeng ZB

更新日期：2009-09-04 00:00:00

abstract：BACKGROUND:Human glycosylase IV is involved in GLUT2 transporter regulation in pancreatic beta cells. A KO of this gene along with a high fat diet in a mice model has been associated with the development of type 2 diabetes (T2D). The aims of this study were to measure and compare the MGAT4A mRNA levels in white blood c...

journal_title：BMC genetics

authors： López-Orduña E,Cruz M,García-Mena J

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine NPY gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The obje...

journal_title：BMC genetics

authors： Bahar B,Sweeney T

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. R...

journal_title：BMC genetics

authors： Butovskaya PR,Lazebny OE,Sukhodolskaya EM,Vasiliev VA,Dronova DA,Fedenok JN,Rosa A,Peletskaya EN,Ryskov AP,Butovskaya ML

更新日期：2016-01-06 00:00:00

abstract：BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...

journal_title：BMC genetics

authors： Druka A,Druka I,Centeno AG,Li H,Sun Z,Thomas WT,Bonar N,Steffenson BJ,Ullrich SE,Kleinhofs A,Wise RP,Close TJ,Potokina E,Luo Z,Wagner C,Schweizer GF,Marshall DF,Kearsey MJ,Williams RW,Waugh R

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...

journal_title：BMC genetics

authors： Symonová R,Havelka M,Amemiya CT,Howell WM,Kořínková T,Flajšhans M,Gela D,Ráb P

更新日期：2017-03-02 00:00:00

abstract：BACKGROUND:X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi) in normal female cells, leaving them with a single active X (Xa) as in male cells. In cells wit...

journal_title：BMC genetics

authors： Gartler SM,Varadarajan KR,Luo P,Norwood TH,Canfield TK,Hansen RS

更新日期：2006-07-03 00:00:00

abstract：BACKGROUND:Hu sheep, a unique Chinese breed with high reproductive performance, are also well known for their rare white lambskin in China. The quality of lambskin is affected by hair follicles, and dermal papilla cells are an important component of hair follicles that plays a key role in hair follicle growth and devel...

journal_title：BMC genetics

authors： Lv X,Gao W,Jin C,Wang L,Wang Y,Chen W,Zou S,Huang S,Li Z,Wang J,Sun W

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Our initial genome-wide association study (GWAS) identified 20 promising candidate genes for milk fatty acid (FA) traits in a Chinese Holstein population, including PRLR, MOGAT1, MINPP1 and CHUK genes. In this study, we performed whether they had significant genetic effects on milk FA traits in Chinese Holst...

journal_title：BMC genetics

authors： Shi L,Liu L,Lv X,Ma Z,Yang Y,Li Y,Zhao F,Sun D,Han B

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...

journal_title：BMC genetics

authors： Divers J,Redden DT,Rice KM,Vaughan LK,Padilla MA,Allison DB,Bluemke DA,Young HJ,Arnett DK

更新日期：2011-03-04 00:00:00

abstract：BACKGROUND:Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in ex...

journal_title：BMC genetics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Szmatoła T,Piórkowska K,Bugno-Poniewierska M

更新日期：2019-09-11 00:00:00

abstract：:We compare and contrast the performance of SIMPLE, a Monte Carlo based software, with that of several other methods for linkage and haplotype analyses, focusing on the simulated data from the New York City population. First, a whole-genome scan study based on the microsatellite markers was performed using GENEHUNTER. ...

journal_title：BMC genetics

authors： Lin S,Ding J,Dong C,Liu Z,Ma ZJ,Wan S,Xu Y

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Foxtail millet (Setaria italica) is a diploid C4 panicoid species. Because of its prominent drought resistance, small genome size, self-pollination, and short life cycle, foxtail millet has become an ideal model system for studying drought tolerance of crops. MicroRNAs (miRNAs) are endogenous, small RNAs tha...

journal_title：BMC genetics

authors： Wang Y,Li L,Tang S,Liu J,Zhang H,Zhi H,Jia G,Diao X

更新日期：2016-04-12 00:00:00

abstract：:Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing data for polygenic models using family data. The imputation schemes take into account familial relationships a...

journal_title：BMC genetics

authors： Fridley B,Rabe K,de Andrade M

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Despite several thousands of years of close contacts, there are genetic differences between the neighbouring countries of Finland and Sweden. Within Finland, signs of an east-west duality have been observed, whereas the population structure within Sweden has been suggested to be more subtle. With a fine-scal...

journal_title：BMC genetics

authors： Hannelius U,Salmela E,Lappalainen T,Guillot G,Lindgren CM,von Döbeln U,Lahermo P,Kere J

更新日期：2008-08-19 00:00:00

abstract：BACKGROUND:Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in t...

journal_title：BMC genetics

authors： Martínez-Arzate SG,Sánchez-Bermúdez JC,Sotelo-Gómez S,Diaz-Albiter HM,Hegazy-Hassan W,Tenorio-Borroto E,Barbabosa-Pliego A,Vázquez-Chagoyán JC

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:The use of pooled DNA on SNP microarrays (SNP-MaP) has been shown to be a cost effective and rapid manner to perform whole-genome association evaluations. While the accuracy of SNP-MaP was extensively evaluated on the early Affymetrix 10 k and 100 k platforms, there have not been as many similarly comprehens...

journal_title：BMC genetics

authors： Anantharaman R,Chew FT

更新日期：2009-12-14 00:00:00

abstract：BACKGROUND:Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. Oculocutaneous albinism was studied in a herd of Murrah buffalo to determine the clinical presentation and genetic basis of albinism in this species. RESULTS:Clinical e...

journal_title：BMC genetics

authors： Damé MC,Xavier GM,Oliveira-Filho JP,Borges AS,Oliveira HN,Riet-Correa F,Schild AL

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:Cymbidium is a genus of 68 species in the orchid family, with extremely high ornamental value. Marker-assisted selection has proven to be an effective strategy in accelerating plant breeding for many plant species. Analysis of cymbidiums genetic background by molecular markers can be of great value in assist...

journal_title：BMC genetics

authors： Li X,Jin F,Jin L,Jackson A,Huang C,Li K,Shu X

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:Boar taint is an unpleasant condition of pork, mainly due to the accumulation of androstenone and skatole in male pigs at onset of puberty. This condition is the cause of considerable economic losses in the pig industry and the most common practice to control it is to castrate male piglets. Because of the ec...

journal_title：BMC genetics

authors： Ramos AM,Duijvesteijn N,Knol EF,Merks JW,Bovenhuis H,Crooijmans RP,Groenen MA,Harlizius B

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least on...

journal_title：BMC genetics

authors： Tortereau F,Sanchez MP,Fève K,Gilbert H,Iannuccelli N,Billon Y,Milan D,Bidanel JP,Riquet J

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare vascular disorder characterized by a capillary wedge pressure ≤ 15 mmHg and a mean pulmonary arterial pressure ≥ 25 mmHg at rest. PAH can be idiopathic, heritable or associated with other conditions. The aim of this study was to analyze the Endoglin (ENG) gene ...

journal_title：BMC genetics

authors： Pousada G,Baloira A,Fontán D,Núñez M,Valverde D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with th...

journal_title：BMC genetics

authors： Velie BD,Fegraeus KJ,Solé M,Rosengren MK,Røed KH,Ihler CF,Strand E,Lindgren G

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...

journal_title：BMC genetics

authors： Woolley SA,Hayes SE,Shariflou MR,Nicholas FW,Willet CE,O'Rourke BA,Tammen I

更新日期：2020-09-15 00:00:00

abstract：:Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...

journal_title：BMC genetics

authors： Papachristou C,Lin S

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Relatively little information is available for sequence variation in the pig. We previously used a combination of short read (25 base pair) high-throughput sequencing and reduced genomic representation to discover > 60,000 single nucleotide polymorphisms (SNP) in cattle, but the current lack of complete geno...

journal_title：BMC genetics

authors： Wiedmann RT,Smith TP,Nonneman DJ

更新日期：2008-12-04 00:00:00