Comparative mapping combined with homology-based cloning of the rice genome reveals candidate genes for grain zinc and iron concentration in maize.

abstract：:We performed a bivariate analysis on cholesterol and triglyceride levels on data from the Framingham Heart Study using a new score statistic developed for the detection of potential pleiotropic, or cluster, genes. Univariate score statistics were also computed for each trait. At a significance level 0.001, linkage sig...

journal_title：BMC genetics

authors： Zhang X,Wang K,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Land plants have evolved several measures to maintain their life against abiotic stresses. The accumulation of proline is the most generalized response of plants under drought, heat or salt stress conditions. It is known as an osmoprotectant which also acts as an instant source of energy during drought recov...

journal_title：BMC genetics

authors： Sayed MA,Schumann H,Pillen K,Naz AA,Léon J

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:Genome-wide investigation of molecular mechanisms for high-altitude adaptation has attracted great attention in the last few years. In order to understand the contribution of gene expression level variations to high-altitude adaptation in Asiatic toads (Bufo gargarizans), we implemented a reciprocal transpla...

journal_title：BMC genetics

authors： Yang W,Qi Y,Lu B,Qiao L,Wu Y,Fu J

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:In humans, muscle-specific nicotinergic acetylcholine receptor (AChR) is a transmembrane protein with five different subunits, coded by CHRNA1, CHRNB, CHRND and CHRNG/CHRNE. The gamma subunit of AChR encoded by CHRNG is expressed during early foetal development, whereas in the adult, the γ subunit is replace...

journal_title：BMC genetics

authors： Kariminejad A,Almadani N,Khoshaeen A,Olsson B,Moslemi AR,Tajsharghi H

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Genomic selection exploits dense genome-wide marker data to predict breeding values. In this study we used a large sugar beet population of 924 lines representing different germplasm types present in breeding populations: unselected segregating families and diverse lines from more advanced stages of selectio...

journal_title：BMC genetics

authors： Würschum T,Reif JC,Kraft T,Janssen G,Zhao Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Pest eradication using the Sterile Insect Technique (SIT) involves high-density releases of sterilized males that mate with wild females and ultimately suppress the population. Sterilized females are not required for SIT and their removal or separation from males prior to release remains challenging. In orde...

journal_title：BMC genetics

authors： Choo A,Fung E,Chen IY,Saint R,Crisp P,Baxter SW

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...

journal_title：BMC genetics

authors： Thutkawkorapin J,Picelli S,Kontham V,Liu T,Nilsson D,Lindblom A

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:To optimize marker-assisted selection programs, knowledge of the genetic architecture of phenotypic traits is very important for breeders. Generally, most phenotypes, e.g. morphological and physiological traits, are quantitatively inherited, and thus detection of the genes underlying variation for these trai...

journal_title：BMC genetics

authors： Wei Z,Zhang G,Du Q,Zhang J,Li B,Zhang D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our re...

journal_title：BMC genetics

authors： Davis SK,Xu R,Gebreab SY,Riestra P,Gaye A,Khan RJ,Wilson JG,Bidulescu A

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:RNA sequencing (RNA-seq) technology has identified multiple differentially expressed (DE) genes associated to complex disease, however, these genes only explain a modest part of variance. Omnigenic model assumes that disease may be driven by genes with indirect relevance to disease and be propagated by funct...

journal_title：BMC genetics

authors： Shao F,Wang Y,Zhao Y,Yang S

更新日期：2019-03-19 00:00:00

abstract：BACKGROUND:The use of pooled DNA on SNP microarrays (SNP-MaP) has been shown to be a cost effective and rapid manner to perform whole-genome association evaluations. While the accuracy of SNP-MaP was extensively evaluated on the early Affymetrix 10 k and 100 k platforms, there have not been as many similarly comprehens...

journal_title：BMC genetics

authors： Anantharaman R,Chew FT

更新日期：2009-12-14 00:00:00

abstract：BACKGROUND:Many QTL studies have two common features: (1) often there is missing marker information, (2) among many markers involved in the biological process only a few are causal. In statistics, the second issue falls under the headings "sparsity" and "causal inference". The goal of this work is to develop a two-step...

journal_title：BMC genetics

authors： Demetrashvili N,Van den Heuvel ER,Wit EC

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage of this approach is that...

journal_title：BMC genetics

authors： Wason JM,Dudbridge F

更新日期：2010-09-09 00:00:00

abstract：:Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...

journal_title：BMC genetics

authors： Papachristou C,Lin S

更新日期：2005-12-30 00:00:00

abstract：:An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance components-based linkage analysis. On the examined simulated, error-free data...

journal_title：BMC genetics

authors： Göring HH,Williams JT,Dyer TD,Blangero J

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity detected in our sample. We performed a mutation screen in 93 extremely obese children and adolescents...

journal_title：BMC genetics

authors： Friedel S,Reichwald K,Scherag A,Brumm H,Wermter AK,Fries HR,Koberwitz K,Wabitsch M,Meitinger T,Platzer M,Biebermann H,Hinney A,Hebebrand J

更新日期：2007-05-03 00:00:00

abstract：BACKGROUND:Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual's susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder c...

journal_title：BMC genetics

authors： Hou J,Gu Y,Hou W,Wu S,Lou Y,Yang W,Zhu L,Hu Y,Sun M,Xue H

更新日期：2015-06-30 00:00:00

abstract：:Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing data for polygenic models using family data. The imputation schemes take into account familial relationships a...

journal_title：BMC genetics

authors： Fridley B,Rabe K,de Andrade M

更新日期：2003-12-31 00:00:00

abstract：:We compare and contrast the performance of SIMPLE, a Monte Carlo based software, with that of several other methods for linkage and haplotype analyses, focusing on the simulated data from the New York City population. First, a whole-genome scan study based on the microsatellite markers was performed using GENEHUNTER. ...

journal_title：BMC genetics

authors： Lin S,Ding J,Dong C,Liu Z,Ma ZJ,Wan S,Xu Y

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...

journal_title：BMC genetics

authors： Li X,Wang X,Zhu H,Liu C,Zhou X,Zhao B,Duan H,Yang J,Gu G,Zhan Y,Yuan J,Abuduwaili K,Qionglu S

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic ...

journal_title：BMC genetics

authors： Giovambattista G,Moe KK,Polat M,Borjigin L,Hein ST,Moe HH,Takeshima SN,Aida Y

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously reported that most individuals with CFEOM1 and rare individuals with CFEOM3 harbor heterozygous mutatio...

journal_title：BMC genetics

authors： Chan WM,Andrews C,Dragan L,Fredrick D,Armstrong L,Lyons C,Geraghty MT,Hunter DG,Yazdani A,Traboulsi EI,Pott JW,Gutowski NJ,Ellard S,Young E,Hanisch F,Koc F,Schnall B,Engle EC

更新日期：2007-05-18 00:00:00

abstract：BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...

journal_title：BMC genetics

authors： Sabbagh A,Langaney A,Darlu P,Gérard N,Krishnamoorthy R,Poloni ES

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of r...

journal_title：BMC genetics

authors： Naz AA,Arifuzzaman M,Muzammil S,Pillen K,Léon J

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS:Published clinical tr...

journal_title：BMC genetics

authors： Wu J,Province MA,Coon H,Hunt SC,Eckfeldt JH,Arnett DK,Heiss G,Lewis CE,Ellison RC,Rao DC,Rice T,Kraja AT

更新日期：2007-09-10 00:00:00

abstract：BACKGROUND:Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine chromosome 14 (BTA14) tog...

journal_title：BMC genetics

authors： Marques E,Schnabel RD,Stothard P,Kolbehdari D,Wang Z,Taylor JF,Moore SS

更新日期：2008-07-08 00:00:00

abstract：BACKGROUND:The Mitotic Exit Network (MEN) proteins - including the protein kinase Cdc15 and the protein phosphatase Cdc14 - are essential for exit from mitosis in Saccharomyces cerevisiae. To identify downstream targets of the MEN, we sought telophase arrest bypassed (tab) mutations that bypassed the essential requirem...

journal_title：BMC genetics

authors： Shou W,Deshaies RJ

更新日期：2002-03-12 00:00:00

abstract：BACKGROUND:Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from unphased ge...

journal_title：BMC genetics

authors： Adkins RM

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:Genetic markers conferring susceptibility to diabetes specific renal disease remains to be identified for early prediction and development of effective drugs and therapies. Inconsistent results obtained from analysis of genes from classical pathways generate need for examination of unconventional genetic mar...

journal_title：BMC genetics

authors： Prasad P,Kumar KM,Ammini AC,Gupta A,Gupta R,Thelma BK

更新日期：2008-03-22 00:00:00