Comparisons of methods for linkage analysis and haplotype reconstruction using extended pedigree data.

abstract：BACKGROUND:Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection agains...

journal_title：BMC genetics

authors： Lewis TW,Blott SC,Woolliams JA

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified using limma package in R software. ...

journal_title：BMC genetics

authors： He J,Gao Y,Wu G,Lei X,Zhang Y,Pan W,Yu H

更新日期：2018-07-20 00:00:00

abstract：:Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...

journal_title：BMC genetics

authors： Ji F,Lee D,Mendell NR

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:Although genome-wide association studies have successfully identified thousands of variants associated to complex traits, these variants only explain a small amount of the entire heritability of the trait. Gene-gene interactions have been proposed as a source to explain a significant percentage of the missin...

journal_title：BMC genetics

authors： Aschard H,Gusev A,Brown R,Pasaniuc B

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Hu sheep, a unique Chinese breed with high reproductive performance, are also well known for their rare white lambskin in China. The quality of lambskin is affected by hair follicles, and dermal papilla cells are an important component of hair follicles that plays a key role in hair follicle growth and devel...

journal_title：BMC genetics

authors： Lv X,Gao W,Jin C,Wang L,Wang Y,Chen W,Zou S,Huang S,Li Z,Wang J,Sun W

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Several lines of evidence including allozyme analysis, restriction digest patterns and sequencing of mtDNA as well as mini- and micro-satellite allele frequencies indicate that Atlantic salmon (Salmo salar) from North America and Europe are genetically distinct. These observations are supported by karyotype ...

journal_title：BMC genetics

authors： Lubieniecki KP,Jones SL,Davidson EA,Park J,Koop BF,Walker S,Davidson WS

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. However, no report has described the effects of GNB1L indels on th...

journal_title：BMC genetics

authors： Ren T,Yang Y,Lin W,Li W,Xian M,Fu R,Zhang Z,Mo G,Luo W,Zhang X

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...

journal_title：BMC genetics

authors： Chen X,Wang J,Hou X,Yue W,Huang S,Wang C

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:Cell motility is an essential feature of the pathogenesis and morbidity of amoebiasis caused by Entamoeba histolytica. As motility depends on cytoskeletal organisation and regulation, a study of the molecular components involved is key to a better understanding of amoebic pathogenesis. However, little is kno...

journal_title：BMC genetics

authors： Zaki M,King J,Fütterer K,Insall RH

更新日期：2007-06-06 00:00:00

abstract：:A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...

journal_title：BMC genetics

authors： Lemire M

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on su...

journal_title：BMC genetics

authors： Haase B,Doherr MG,Seuberlich T,Drögemüller C,Dolf G,Nicken P,Schiebel K,Ziegler U,Groschup MH,Zurbriggen A,Leeb T

更新日期：2007-04-16 00:00:00

abstract：BACKGROUND:Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian t...

journal_title：BMC genetics

authors： Maciąg A,Villa F,Ferrario A,Spinelli CC,Carrizzo A,Malovini A,Torella A,Montenero C,Parisi A,Condorelli G,Vecchione C,Nigro V,Montenero AS,Puca AA

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:To optimize marker-assisted selection programs, knowledge of the genetic architecture of phenotypic traits is very important for breeders. Generally, most phenotypes, e.g. morphological and physiological traits, are quantitatively inherited, and thus detection of the genes underlying variation for these trai...

journal_title：BMC genetics

authors： Wei Z,Zhang G,Du Q,Zhang J,Li B,Zhang D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...

journal_title：BMC genetics

authors： Hothorn LA,Libiger O,Gerhard D

更新日期：2012-07-18 00:00:00

abstract：BACKGROUND:There is increasing evidence that the ability to adapt to seawater in teleost fish is modulated by genetic factors. Most studies have involved the comparison of species or strains and little is known about the genetic architecture of the trait. To address this question, we searched for QTL affecting osmoregu...

journal_title：BMC genetics

authors： Le Bras Y,Dechamp N,Krieg F,Filangi O,Guyomard R,Boussaha M,Bovenhuis H,Pottinger TG,Prunet P,Le Roy P,Quillet E

更新日期：2011-05-14 00:00:00

abstract：BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...

journal_title：BMC genetics

authors： Huang XQ,Cloutier S

更新日期：2007-05-04 00:00:00

abstract：BACKGROUND:The cultivated peanut (Arachis hypogaea L.) is an important oil and food crop in the world. Pod- and kernel-related traits are direct factors involved in determining the yield of the peanut. However, the genetic basis underlying pod- and kernel-related traits in the peanut remained largely unknown, which ham...

journal_title：BMC genetics

authors： Chen W,Jiao Y,Cheng L,Huang L,Liao B,Tang M,Ren X,Zhou X,Chen Y,Jiang H

更新日期：2016-01-25 00:00:00

abstract：BACKGROUND:The disease gene of fragile X syndrome, FMR1 gene, encodes fragile X mental retardation protein (FMRP). The alternative splicing (AS) of FMR1 can affect the structure and function of FMRP. However, the biological functions of alternatively spliced isoforms remain elusive. In a previous study, we identified a...

journal_title：BMC genetics

authors： Yang WJ,Yan AZ,Xu YJ,Guo XY,Fu XG,Li D,Liao J,Zhang D,Lan FH

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi) in normal female cells, leaving them with a single active X (Xa) as in male cells. In cells wit...

journal_title：BMC genetics

authors： Gartler SM,Varadarajan KR,Luo P,Norwood TH,Canfield TK,Hansen RS

更新日期：2006-07-03 00:00:00

abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and their target binding sites affect miRNA function and are involved in biological processes and diseases, including bovine mastitis, a frequent inflammatory disease. Our previous study has shown that bta-miR-2899 is significantly upregulated in t...

journal_title：BMC genetics

authors： Jiang Q,Zhao H,Li R,Zhang Y,Liu Y,Wang J,Wang X,Ju Z,Liu W,Hou M,Huang J

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：:A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...

journal_title：BMC genetics

authors： Yang HC,Chang CC,Lin CY,Chen CL,Lin CY,Fann CS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The human Prader-Willi syndrome (PWS) domain and its mouse orthologue include a cluster of paternally expressed genes which imprinted expression is co-ordinately regulated by an imprinting center (IC) closely associated to the Snurf-Snrpn gene. Besides their co-regulated imprinted expression, two observation...

journal_title：BMC genetics

authors： Watrin F,Le Meur E,Roeckel N,Ripoche MA,Dandolo L,Muscatelli F

更新日期：2005-01-05 00:00:00

abstract：BACKGROUND:Egg production is the most economically-important trait in layers as it directly influences benefits of the poultry industry. To better understand the genetic architecture of egg production, we measured traits including age at first egg (AFE), weekly egg number (EN) from onset of laying eggs to 80 weeks whic...

journal_title：BMC genetics

authors： Liu Z,Yang N,Yan Y,Li G,Liu A,Wu G,Sun C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Pest eradication using the Sterile Insect Technique (SIT) involves high-density releases of sterilized males that mate with wild females and ultimately suppress the population. Sterilized females are not required for SIT and their removal or separation from males prior to release remains challenging. In orde...

journal_title：BMC genetics

authors： Choo A,Fung E,Chen IY,Saint R,Crisp P,Baxter SW

更新日期：2020-12-18 00:00:00

abstract：:Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...

journal_title：BMC genetics

authors： Jacobs KB,Gray-McGuire C,Cartier KC,Elston RC

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:The Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative de...

journal_title：BMC genetics

authors： Clark L,Wei M,Cattoretti G,Mendelsohn C,Tycko B

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

journal_title：BMC genetics

authors： Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

更新日期：2007-07-28 00:00:00

abstract：BACKGROUND:In this article, I propose a model-selection-free method to map multiple quantitative trait loci (QTL) in variance component model, which is useful in outbred populations. The new method can estimate the variance of zero-effect QTL infinitely to zero, but nearly unbiased for non-zero-effect QTL. It is analog...

journal_title：BMC genetics

authors： Fang M

更新日期：2010-04-29 00:00:00