Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13.

abstract：BACKGROUND:Genetic maps characterizing the inheritance patterns of traits and markers have been developed for a wide range of species and used to study questions in biomedicine, agriculture, ecology and evolutionary biology. The status of rainbow trout genetic maps has progressed significantly over the last decade due ...

journal_title：BMC genetics

authors： Rexroad CE 3rd,Palti Y,Gahr SA,Vallejo RL

更新日期：2008-11-19 00:00:00

abstract：BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...

journal_title：BMC genetics

authors： Brunson T,Wang Q,Chambers I,Song Q

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported a...

journal_title：BMC genetics

authors： Chen H,Xu J,Zhou Y,Gao Y,Wang G,Xia J,Huen MS,Siok WT,Jiang Y,Tan LH,Sun Y

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Moths of genus Dendrolimus (Lepidoptera: Lasiocampidae) are among the major pests of coniferous forests worldwide. Taxonomy and nomenclature of this genus are not entirely established, and there are many species with a controversial taxonomic position. We present a comparative evolutionary analysis of the mo...

journal_title：BMC genetics

authors： Kononov A,Ustyantsev K,Wang B,Mastro VC,Fet V,Blinov A,Baranchikov Y

更新日期：2016-12-22 00:00:00

abstract：:Genome read categorization determines the genome of origin for sequence reads from an allopolyploid organism. Different techniques have been used to perform read categorization, mostly based on homoeo-SNPs identified between extant diploid relatives of allopolyploids. We present a novel technique for read categorizati...

journal_title：BMC genetics

authors： Page JT,Udall JA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:MUC4 is a type of membrane anchored glycoprotein and serves as the major constituent of mucus that covers epithelial surfaces of many tissues such as trachea, colon and cervix. MUC4 plays important roles in the lubrication and protection of the surface epithelium, cell proliferation and differentiation, immu...

journal_title：BMC genetics

authors： Yang M,Yang B,Yan X,Ouyang J,Zeng W,Ai H,Ren J,Huang L

更新日期：2012-07-13 00:00:00

abstract：BACKGROUND:Discerning the traits evolving under neutral conditions from those traits evolving rapidly because of various selection pressures is a great challenge. We propose a new method, composite selection signals (CSS), which unifies the multiple pieces of selection evidence from the rank distribution of its diverse...

journal_title：BMC genetics

authors： Randhawa IA,Khatkar MS,Thomson PC,Raadsma HW

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the association in women is unclear. Since lipid levels vary between the sexes the antioxidant effect of ...

journal_title：BMC genetics

authors： Lawlor DA,Day IN,Gaunt TR,Hinks LJ,Briggs PJ,Kiessling M,Timpson N,Smith GD,Ebrahim S

更新日期：2004-06-23 00:00:00

abstract：BACKGROUND:Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study, we aimed to identify major QTLs for kernel length, as well as putative candidate genes that migh...

journal_title：BMC genetics

authors： Zhou H,Liu S,Liu Y,Liu Y,You J,Deng M,Ma J,Chen G,Wei Y,Liu C,Zheng Y

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...

journal_title：BMC genetics

authors： Rahmatalla SA,Arends D,Reissmann M,Said Ahmed A,Wimmers K,Reyer H,Brockmann GA

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Egg production is the most economically-important trait in layers as it directly influences benefits of the poultry industry. To better understand the genetic architecture of egg production, we measured traits including age at first egg (AFE), weekly egg number (EN) from onset of laying eggs to 80 weeks whic...

journal_title：BMC genetics

authors： Liu Z,Yang N,Yan Y,Li G,Liu A,Wu G,Sun C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on su...

journal_title：BMC genetics

authors： Haase B,Doherr MG,Seuberlich T,Drögemüller C,Dolf G,Nicken P,Schiebel K,Ziegler U,Groschup MH,Zurbriggen A,Leeb T

更新日期：2007-04-16 00:00:00

abstract：BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...

journal_title：BMC genetics

authors： Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu S

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...

journal_title：BMC genetics

authors： Symonová R,Havelka M,Amemiya CT,Howell WM,Kořínková T,Flajšhans M,Gela D,Ráb P

更新日期：2017-03-02 00:00:00

abstract：BACKGROUND:Hybrid breakdown has been well documented in various species. Relationships between genomic heterozygosity and traits-fitness have been extensively explored especially in the natural populations. But correlations between genomic heterozygosity and vegetative and reproductive traits in cotton interspecific po...

journal_title：BMC genetics

authors： Dai B,Guo H,Huang C,Zhang X,Lin Z

更新日期：2016-04-12 00:00:00

abstract：:The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...

journal_title：BMC genetics

authors： Liu X,Jorgenson E,Witte JS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation. Activating mutations severely limit bone growth, resulting in dwarfism, while inactivating mutations significantly enhance bone elongation and overa...

journal_title：BMC genetics

authors： Smith LB,Bannasch DL,Young AE,Grossman DI,Belanger JM,Oberbauer AM

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic ...

journal_title：BMC genetics

authors： Giovambattista G,Moe KK,Polat M,Borjigin L,Hein ST,Moe HH,Takeshima SN,Aida Y

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

journal_title：BMC genetics

authors： Hussey DJ,Moore S,Nicola M,Dobrovic A

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative de...

journal_title：BMC genetics

authors： Clark L,Wei M,Cattoretti G,Mendelsohn C,Tycko B

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...

journal_title：BMC genetics

authors： Li X,Wang X,Zhu H,Liu C,Zhou X,Zhao B,Duan H,Yang J,Gu G,Zhan Y,Yuan J,Abuduwaili K,Qionglu S

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confu...

journal_title：BMC genetics

authors： Wang T,Zeng ZB

更新日期：2009-09-04 00:00:00

abstract：BACKGROUND:Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in multiple epithelia during later development. Both insertions caused recessive mutations that r...

journal_title：BMC genetics

authors： Serth K,Beckers A,Schuster-Gossler K,Pavlova MN,Müller J,Paul MC,Reinhardt R,Gossler A

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...

journal_title：BMC genetics

authors： Chen X,Wang J,Hou X,Yue W,Huang S,Wang C

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...

journal_title：BMC genetics

authors： Fernández AI,Muñoz M,Alves E,Folch JM,Noguera JL,Enciso MP,Rodríguez Mdel C,Silió L

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Patellar luxation is an orthopedic disorder in which the patella moves out of its normal location within the femoral trochlea of the knee and it can lead to osteoarthritis, lameness, and pain. In dogs it is a heritable trait, with both environmental and genetic factors contributing to the phenotype. The prev...

journal_title：BMC genetics

authors： Lavrijsen IC,Leegwater PA,Wangdee C,van Steenbeek FG,Schwencke M,Breur GJ,Meutstege FJ,Nijman IJ,Cuppen E,Heuven HC,Hazewinkel HA

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:Monogenic diabetes is a genetic disease often caused by mutations in genes involved in beta-cell function. Correct sub-categorization of the disease is a prerequisite for appropriate treatment and genetic counseling. Target-region capture sequencing is a combination of genomic region enrichment and next gene...

journal_title：BMC genetics

authors： Gao R,Liu Y,Gjesing AP,Hollensted M,Wan X,He S,Pedersen O,Yi X,Wang J,Hansen T

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...

journal_title：BMC genetics

authors： Biscarini F,Stevanato P,Broccanello C,Stella A,Saccomani M

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Transgenic poplar (Populus × euramericana 'Guariento') plants harboring five exogenous, stress-related genes exhibit increased tolerance to multiple stresses including drought, salt, waterlogging, and insect feeding, but the complex mechanisms underlying stress tolerance in these plants have not been elucida...

journal_title：BMC genetics

authors： Zhang W,Chu Y,Ding C,Zhang B,Huang Q,Hu Z,Huang R,Tian Y,Su X

更新日期：2014-01-01 00:00:00