A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle.

abstract：BACKGROUND:Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for ...

journal_title：BMC genetics

authors： Jin T,Chen J,Zhu L,Zhao Y,Guo J,Huang Y

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection agains...

journal_title：BMC genetics

authors： Lewis TW,Blott SC,Woolliams JA

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage of this approach is that...

journal_title：BMC genetics

authors： Wason JM,Dudbridge F

更新日期：2010-09-09 00:00:00

abstract：BACKGROUND:The Africanized honey bee is one of the most spectacular invasions in the Americas. African bees escaped from apiaries in Brazil in 1956, spread over Americas and by 1994 they were reported in Puerto Rico. In contrast to other places, the oceanic island conditions in Puerto Rico may mean a single introductio...

journal_title：BMC genetics

authors： Galindo-Cardona A,Acevedo-Gonzalez JP,Rivera-Marchand B,Giray T

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Retinal function is ordered by interactions between transcriptional and posttranscriptional regulators at the molecular level. These regulators include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs). Some studies propose that miRs predominantly target the TFs rather than...

journal_title：BMC genetics

authors： Andreeva K,Soliman MM,Cooper NG

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...

journal_title：BMC genetics

authors： Brunson T,Wang Q,Chambers I,Song Q

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Two key questions in understanding the genetic control of behaviors are: what genes are involved and how these genes interact. To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. RESULTS:We studied 69 genes whose ...

journal_title：BMC genetics

authors： Aleman-Meza B,Loeza-Cabrera M,Peña-Ramos O,Stern M,Zhong W

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:Growth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accurate prediction of breeding values of animals without own phenotypic information. This study investiga...

journal_title：BMC genetics

authors： Liu T,Qu H,Luo C,Shu D,Wang J,Lund MS,Su G

更新日期：2014-10-15 00:00:00

abstract：:The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted ...

journal_title：BMC genetics

authors： Brown WM,Beck SR,Lange EM,Davis CC,Kay CM,Langefeld CD,Rich SS,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Cytoplasmic effects on agronomic traits--involving cytoplasmic and nuclear genomes of either different species or different cultivars--are well documented in wheat but have seldom been demonstrated in rice (Oryza sativa L.). To detect cytoplasmic effects, we introgressed the nuclear genomes of three indica c...

journal_title：BMC genetics

authors： Tao D,Xu P,Zhou J,Deng X,Li J,Deng W,Yang J,Yang G,Li Q,Hu F

更新日期：2011-06-01 00:00:00

abstract：:The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study this question, two types of covariate models were used in the simulated Genetic Analysis Workshop 14 dataset i...

journal_title：BMC genetics

authors： Bailey JN

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...

journal_title：BMC genetics

authors： Divers J,Redden DT,Rice KM,Vaughan LK,Padilla MA,Allison DB,Bluemke DA,Young HJ,Arnett DK

更新日期：2011-03-04 00:00:00

abstract：BACKGROUND:We previously conducted a genome-wide association study (GWAS) strategy for milk fatty acids in Chinese Holstein, and identified 83 genome-wide significant single nucleotide polymorphisms (SNPs) and 314 suggestive significant SNPs. Among them, two SNPs, BTB-01077939 and BTA-11275-no-rs associated with C10:0,...

journal_title：BMC genetics

authors： Shi L,Lv X,Liu L,Yang Y,Ma Z,Han B,Sun D

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:MUC4 is a type of membrane anchored glycoprotein and serves as the major constituent of mucus that covers epithelial surfaces of many tissues such as trachea, colon and cervix. MUC4 plays important roles in the lubrication and protection of the surface epithelium, cell proliferation and differentiation, immu...

journal_title：BMC genetics

authors： Yang M,Yang B,Yan X,Ouyang J,Zeng W,Ai H,Ren J,Huang L

更新日期：2012-07-13 00:00:00

abstract：BACKGROUND:The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, from national newborn screening programs may provide a DNA source for entire populations. Combined ...

journal_title：BMC genetics

authors： Hollegaard MV,Grove J,Grauholm J,Kreiner-Møller E,Bønnelykke K,Nørgaard M,Benfield TL,Nørgaard-Pedersen B,Mortensen PB,Mors O,Sørensen HT,Harboe ZB,Børglum AD,Demontis D,Ørntoft TF,Bisgaard H,Hougaard DM

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Intronic DNA sequences of the canine arrestin (SAG) gene was screened to identify potential disease causing mutations in dogs with generalized progressive retinal atrophy (gPRA). The intronic sequences flanking each of the 16 exons were obtained from clones of a canine genomic library. RESULTS:Using polymer...

journal_title：BMC genetics

authors： Dekomien G,Epplen JT

更新日期：2002-07-17 00:00:00

abstract：BACKGROUND:Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in multiple epithelia during later development. Both insertions caused recessive mutations that r...

journal_title：BMC genetics

authors： Serth K,Beckers A,Schuster-Gossler K,Pavlova MN,Müller J,Paul MC,Reinhardt R,Gossler A

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Cymbidium is a genus of 68 species in the orchid family, with extremely high ornamental value. Marker-assisted selection has proven to be an effective strategy in accelerating plant breeding for many plant species. Analysis of cymbidiums genetic background by molecular markers can be of great value in assist...

journal_title：BMC genetics

authors： Li X,Jin F,Jin L,Jackson A,Huang C,Li K,Shu X

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...

journal_title：BMC genetics

authors： Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu S

更新日期：2015-12-03 00:00:00

abstract：:A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...

journal_title：BMC genetics

authors： Lemire M

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Relatively little information is available for sequence variation in the pig. We previously used a combination of short read (25 base pair) high-throughput sequencing and reduced genomic representation to discover > 60,000 single nucleotide polymorphisms (SNP) in cattle, but the current lack of complete geno...

journal_title：BMC genetics

authors： Wiedmann RT,Smith TP,Nonneman DJ

更新日期：2008-12-04 00:00:00

abstract：BACKGROUND:Linkage disequilibrium (LD) mapping is commonly used to evaluate markers for genome-wide association studies. Most types of LD software focus strictly on LD analysis and visualization, but lack supporting services for genotyping. RESULTS:We developed a freeware called LD2SNPing, which provides a complete pa...

journal_title：BMC genetics

authors： Chang HW,Chuang LY,Chang YJ,Cheng YH,Hung YC,Chen HC,Yang CH

更新日期：2009-06-06 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...

journal_title：BMC genetics

authors： Silva NM,Rio J,Currat M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Yami and Ivatan islanders are Austronesian speakers from Orchid Island and the Batanes archipelago that are located between Taiwan and the Philippines. The paternal genealogies of the Yami tribe from 1962 monograph of Wei and Liu were compared with our dataset of non-recombining Y (NRY) chromosomes from the ...

journal_title：BMC genetics

authors： Loo JH,Trejaut JA,Yen JC,Chen ZS,Lee CL,Lin M

更新日期：2011-01-31 00:00:00

abstract：BACKGROUND:Our initial genome-wide association study (GWAS) identified 20 promising candidate genes for milk fatty acid (FA) traits in a Chinese Holstein population, including PRLR, MOGAT1, MINPP1 and CHUK genes. In this study, we performed whether they had significant genetic effects on milk FA traits in Chinese Holst...

journal_title：BMC genetics

authors： Shi L,Liu L,Lv X,Ma Z,Yang Y,Li Y,Zhao F,Sun D,Han B

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:There are at least 25 human selenoproteins, each characterized by the incorporation of selenium into the primary sequence as the amino acid selenocysteine. Since many selenoproteins have antioxidant properties, it is plausible that inter-individual differences in selenoprotein expression or activity could in...

journal_title：BMC genetics

authors： Foster CB,Aswath K,Chanock SJ,McKay HF,Peters U

更新日期：2006-12-11 00:00:00

abstract：BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...

journal_title：BMC genetics

authors： Li X,Wang X,Zhu H,Liu C,Zhou X,Zhao B,Duan H,Yang J,Gu G,Zhan Y,Yuan J,Abuduwaili K,Qionglu S

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine NPY gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The obje...

journal_title：BMC genetics

authors： Bahar B,Sweeney T

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

journal_title：BMC genetics

authors： Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

更新日期：2010-12-07 00:00:00

abstract：:Participants in the family-based analysis group at Genetic Analysis Workshop 19 addressed diverse topics, all of which used the family data. Topics addressed included questions of study design and data quality control (QC), genotype imputation to augment available sequence data, and linkage and/or association analyses...

journal_title：BMC genetics

authors： Wijsman EM

更新日期：2016-02-03 00:00:00