Genetic diversity and population structure of the Sapsaree, a native Korean dog breed.

abstract：BACKGROUND:Genetic improvement of beef quality will benefit both producers and consumers, and can be achieved by selecting animals that carry desired quantitative trait nucleotides (QTN), which result from intensive searches using genetic markers. This paper presents a genome-wide association approach utilizing single ...

journal_title：BMC genetics

authors： Lu D,Sargolzaei M,Kelly M,Vander Voort G,Wang Z,Mandell I,Moore S,Plastow G,Miller SP

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:Peach [Prunus persica (L.) Batsch] is one of the most economically important fruit crops that, due to its genetic and biological characteristics (small genome size, taxonomic proximity to other important species and short juvenile period), has become a model plant in genomic studies of fruit trees. Our aim w...

journal_title：BMC genetics

authors： Aranzana MJ,Abbassi el-K,Howad W,Arús P

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine chromosome 14 (BTA14) tog...

journal_title：BMC genetics

authors： Marques E,Schnabel RD,Stothard P,Kolbehdari D,Wang Z,Taylor JF,Moore SS

更新日期：2008-07-08 00:00:00

abstract：:A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...

journal_title：BMC genetics

authors： Yang HC,Chang CC,Lin CY,Chen CL,Lin CY,Fann CS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, from national newborn screening programs may provide a DNA source for entire populations. Combined ...

journal_title：BMC genetics

authors： Hollegaard MV,Grove J,Grauholm J,Kreiner-Møller E,Bønnelykke K,Nørgaard M,Benfield TL,Nørgaard-Pedersen B,Mortensen PB,Mors O,Sørensen HT,Harboe ZB,Børglum AD,Demontis D,Ørntoft TF,Bisgaard H,Hougaard DM

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:The SNF3 gene in the yeast Saccharomyces cerevisiae encodes a low glucose sensor that regulates expression of an important subset of the hexose transporter (HXT) superfamily. Null mutations of snf3 result in a defect in growth on low glucose concentrations due to the inability to relieve repression of a subs...

journal_title：BMC genetics

authors： Dietzel KL,Ramakrishnan V,Murphy EE,Bisson LF

更新日期：2012-12-12 00:00:00

abstract：:This study, part of the Genetic Analysis Workshop 14 (GAW14), explored real Collaborative Study on the Genetics of Alcoholism data for linkage and association mapping between genetic polymorphisms (microsatellite and single-nucleotide polymorphisms (SNPs)) and beta (16.5-20 Hz) oscillations of the brain rhythms (ecb21...

journal_title：BMC genetics

authors： Kraja AT,Borecki IB,Province MA

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Hu sheep, a unique Chinese breed with high reproductive performance, are also well known for their rare white lambskin in China. The quality of lambskin is affected by hair follicles, and dermal papilla cells are an important component of hair follicles that plays a key role in hair follicle growth and devel...

journal_title：BMC genetics

authors： Lv X,Gao W,Jin C,Wang L,Wang Y,Chen W,Zou S,Huang S,Li Z,Wang J,Sun W

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Boar taint is an unpleasant condition of pork, mainly due to the accumulation of androstenone and skatole in male pigs at onset of puberty. This condition is the cause of considerable economic losses in the pig industry and the most common practice to control it is to castrate male piglets. Because of the ec...

journal_title：BMC genetics

authors： Ramos AM,Duijvesteijn N,Knol EF,Merks JW,Bovenhuis H,Crooijmans RP,Groenen MA,Harlizius B

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Congenital heart defects (CHD) is the most common cause of death from a congenital structure abnormality in newborns and is often associated with fetal loss. There are many types of CHD. Human genetic studies have identified genes that are responsible for the inheritance of a particular type of CHD and for s...

journal_title：BMC genetics

authors： Flaquer A,Baumbach C,Piñero E,García Algas F,de la Fuente Sanchez MA,Rosell J,Toquero J,Alonso-Pulpon L,Garcia-Pavia P,Strauch K,Heine-Suñer D

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Hybrid breakdown has been well documented in various species. Relationships between genomic heterozygosity and traits-fitness have been extensively explored especially in the natural populations. But correlations between genomic heterozygosity and vegetative and reproductive traits in cotton interspecific po...

journal_title：BMC genetics

authors： Dai B,Guo H,Huang C,Zhang X,Lin Z

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Wheat leaf rust is an important disease worldwide. Understanding the pathogenic molecular mechanism of Puccinia triticina Eriks. (Pt) and the inconstant toxic region is critical for managing the disease. The present study aimed to analyze the pathogenic divergence between Pt isolates. RESULTS:Total RNA was ...

journal_title：BMC genetics

authors： Wei J,Cui L,Zhang N,Du D,Meng Q,Yan H,Liu D,Yang W

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...

journal_title：BMC genetics

authors： Divers J,Redden DT,Rice KM,Vaughan LK,Padilla MA,Allison DB,Bluemke DA,Young HJ,Arnett DK

更新日期：2011-03-04 00:00:00

abstract：BACKGROUND:Fenofibrate (Fb) is a known treatment for elevated triglyceride (TG) levels. The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study was designed to investigate potential contributors to the effects of Fb on TG levels. Here, we summarize the analyses of 8 papers whose authors had access to the GO...

journal_title：BMC genetics

authors： Cherlin S,Wang MH,Bickeböller H,Cantor RM

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:The human Prader-Willi syndrome (PWS) domain and its mouse orthologue include a cluster of paternally expressed genes which imprinted expression is co-ordinately regulated by an imprinting center (IC) closely associated to the Snurf-Snrpn gene. Besides their co-regulated imprinted expression, two observation...

journal_title：BMC genetics

authors： Watrin F,Le Meur E,Roeckel N,Ripoche MA,Dandolo L,Muscatelli F

更新日期：2005-01-05 00:00:00

abstract：BACKGROUND:DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity detected in our sample. We performed a mutation screen in 93 extremely obese children and adolescents...

journal_title：BMC genetics

authors： Friedel S,Reichwald K,Scherag A,Brumm H,Wermter AK,Fries HR,Koberwitz K,Wabitsch M,Meitinger T,Platzer M,Biebermann H,Hinney A,Hebebrand J

更新日期：2007-05-03 00:00:00

abstract：BACKGROUND:Cattle are bred for, amongst other factors, specific traits, including parasite resistance and adaptation to climate. However, the influence and inheritance of mitochondrial DNA (mtDNA) are not usually considered in breeding programmes. In this study, we analysed the mtDNA profiles of cattle from Victoria (V...

journal_title：BMC genetics

authors： Srirattana K,McCosker K,Schatz T,St John JC

更新日期：2017-06-26 00:00:00

abstract：BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...

journal_title：BMC genetics

authors： Biscarini F,Stevanato P,Broccanello C,Stella A,Saccomani M

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:To optimize marker-assisted selection programs, knowledge of the genetic architecture of phenotypic traits is very important for breeders. Generally, most phenotypes, e.g. morphological and physiological traits, are quantitatively inherited, and thus detection of the genes underlying variation for these trai...

journal_title：BMC genetics

authors： Wei Z,Zhang G,Du Q,Zhang J,Li B,Zhang D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. However, no report has described the effects of GNB1L indels on th...

journal_title：BMC genetics

authors： Ren T,Yang Y,Lin W,Li W,Xian M,Fu R,Zhang Z,Mo G,Luo W,Zhang X

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:In a deep sequencing analysis of small RNAs prepared from a living fossil, the tadpole shrimp Triops cancriformis, a 32-nt small RNA was specifically detected in the adult stage. A nucleotide sequence comparison between the 32-nt small RNA and predicted tRNA sequences in the draft nuclear genomic DNA showed ...

journal_title：BMC genetics

authors： Hirose Y,Ikeda KT,Noro E,Hiraoka K,Tomita M,Kanai A

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome. RESULTS:We isolated 11 lethal lines that map...

journal_title：BMC genetics

authors： Boles MK,Wilkinson BM,Maxwell A,Lai L,Mills AA,Nishijima I,Salinger AP,Moskowitz I,Hirschi KK,Liu B,Bradley A,Justice MJ

更新日期：2009-03-06 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation. Activating mutations severely limit bone growth, resulting in dwarfism, while inactivating mutations significantly enhance bone elongation and overa...

journal_title：BMC genetics

authors： Smith LB,Bannasch DL,Young AE,Grossman DI,Belanger JM,Oberbauer AM

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. Transcription of SLa is enhanced or suppressed when fish are kept in dark or bright conditions, respectively, indicating SLa's important ro...

journal_title：BMC genetics

authors： Sasano Y,Yoshimura A,Fukamachi S

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from unphased ge...

journal_title：BMC genetics

authors： Adkins RM

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...

journal_title：BMC genetics

authors： Goryca K,Kulecka M,Paziewska A,Dabrowska M,Grzelak M,Skrzypczak M,Ginalski K,Mroz A,Rutkowski A,Paczkowska K,Mikula M,Ostrowski J

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic ...

journal_title：BMC genetics

authors： Giovambattista G,Moe KK,Polat M,Borjigin L,Hein ST,Moe HH,Takeshima SN,Aida Y

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under t...

journal_title：BMC genetics

authors： Park JY,Wu C,Pan W

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:The extent of linkage disequilibrium (LD) is of critical importance for genomic selection and marker assisted selection. The primary purpose of this study is to examine patterns of LD in three Danish pig breeds (Duroc, Landrace and Yorkshire); we also examine patterns of persistence of phase between the bree...

journal_title：BMC genetics

authors： Wang L,Sørensen P,Janss L,Ostersen T,Edwards D

更新日期：2013-12-05 00:00:00