Abstract:
BACKGROUND:The SNF3 gene in the yeast Saccharomyces cerevisiae encodes a low glucose sensor that regulates expression of an important subset of the hexose transporter (HXT) superfamily. Null mutations of snf3 result in a defect in growth on low glucose concentrations due to the inability to relieve repression of a subset of the HXT genes. The snf3 null mutation phenotype is suppressed by the loss of either one of the downstream co-repressor proteins Rgt1p or Mth1p. The relief of repression allows expression of HXT transporter proteins, the resumption of glucose uptake and therefore of growth in the absence of a functional Snf3 sensor. RESULTS:Strains heterozygous for both the RGT1 and MTH1 genes (RGT1/rgt1Δ MTH1/mth1Δ snf3Δ/snf3Δ) but homozygous for the snf3∆ were found to grow on low glucose. Since null alleles in the heterozygous state lead to suppression, MTH1 and RGT1 display the phenomenon of combined haploinsufficiency. This observed haploinsufficiency is consistent with the finding of repressor titration as a mechanism of suppression of snf3. Mutants of the STD1 homolog of MTH1 did not display haploinsufficiency singly or in combination with mutations in RGT1. HXT gene reporter fusion assays indicated that the presence of heterozygosity at the MTH1 and RGT1 alleles leads to increased expression of the HXT2 gene. Deletion of the HXT2 gene in a heterozygous diploid, RGT1/rgt1Δ MTH1/mth1Δ snf3Δ/snf3Δ hxt2Δ/hxt2Δ, prevented the suppression of snf3Δ. CONCLUSIONS:These findings support the model of relief of repression as the mechanism of restoration of growth on low glucose concentrations in the absence of functional Snf3p. Further, the observation that HXT2 is the gene responsible for restoration of growth under these conditions suggests that the numbers of repressor binding domains found in the regulatory regions of members of the HXT family may have biological relevance and enable differential regulation.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Dietzel KL,Ramakrishnan V,Murphy EE,Bisson LFdoi
10.1186/1471-2156-13-107subject
Has Abstractpub_date
2012-12-12 00:00:00pages
107issn
1471-2156pii
1471-2156-13-107journal_volume
13pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:The spotted-wing Drosophila (Drosophila suzukii) is a widespread invasive pest that causes severe economic damage to fruit crops. The early development of D. suzukii is similar to that of other Drosophilids, but the roles of individual genes must be confirmed experimentally. Cellularization genes coordinate ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00939-y
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:The SnRKs (sucrose non-fermenting 1 related protein kinase) are a gene family coding for Ser/Thr protein kinases and play important roles in linking the tolerance and metabolic responses of plants to abiotic stresses. To date, no genome-wide characterization of the sucrose non-ferment 1 related protein kinas...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0506-6
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Non-invasive sampling has opened avenues for the genetic study of elusive species, which has contributed significantly to their conservation. Where field based identity of non-invasive sample is ambiguous (e.g. carnivore scats), it is essential to establish identity of the species through molecular approache...
journal_title:BMC genetics
pub_type: 杂志文章,评审
doi:10.1186/s12863-016-0344-y
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0467-1
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:In this article, I propose a model-selection-free method to map multiple quantitative trait loci (QTL) in variance component model, which is useful in outbred populations. The new method can estimate the variance of zero-effect QTL infinitely to zero, but nearly unbiased for non-zero-effect QTL. It is analog...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-30
更新日期:2010-04-29 00:00:00
abstract:BACKGROUND:Plant calmodulin-binding transcription activator (CAMTA) proteins play important roles in hormone signal transduction, developmental regulation, and environmental stress tolerance. However, in wheat, the CAMTA gene family has not been systematically characterized. RESULTS:In this work, 15 wheat CAMTA genes ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00916-5
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS:Published clinical tr...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-60
更新日期:2007-09-10 00:00:00
abstract:BACKGROUND:Tyrosinemia type I, the most severe disease of the tyrosine catabolic pathway is caused by a deficiency in fumarylacetoacetate hydrolase (FAH). A patient showing few of the symptoms associated with the disease, was found to be a compound heterozygote for a splice mutation, IVS6-1g->t, and a putative missense...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-2-9
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0176-1
更新日期:2015-02-14 00:00:00
abstract:BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-2-20
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Field pea (Pisum sativum L.) is among the prominent crops in the world as food and feed. There are relatively few simple sequence repeat (SSR) markers developed from expressed sequence tags (ESTs) in P. sativum. RESULTS:In the present study, 15 new EST-SSR markers were developed from publicly available ESTs...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0261-5
更新日期:2015-08-19 00:00:00
abstract:BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0484-8
更新日期:2017-03-02 00:00:00
abstract:BACKGROUND:Complex diseases are believed to be the results of many genes and environmental factors. Hence, multi-marker methods that can use the information of markers from different genes are appropriate for mapping complex disease genes. There already have been several multi-marker methods proposed for case-control s...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-65
更新日期:2007-09-25 00:00:00
abstract:BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0553-z
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS:In 2027 participants rando...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0272-2
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:India is home to many ethnically and linguistically diverse populations. It is hypothesized that history of invasions by people from Persia and Central Asia, who are referred as Aryans in Hindu Holy Scriptures, had a defining role in shaping the Indian population canvas. A shift in spoken languages from Drav...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-86
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-18
更新日期:2007-05-04 00:00:00
abstract::Genome read categorization determines the genome of origin for sequence reads from an allopolyploid organism. Different techniques have been used to perform read categorization, mostly based on homoeo-SNPs identified between extant diploid relatives of allopolyploids. We present a novel technique for read categorizati...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-16-S2-S4
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of r...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0107-6
更新日期:2014-10-07 00:00:00
abstract::This study, part of the Genetic Analysis Workshop 14 (GAW14), explored real Collaborative Study on the Genetics of Alcoholism data for linkage and association mapping between genetic polymorphisms (microsatellite and single-nucleotide polymorphisms (SNPs)) and beta (16.5-20 Hz) oscillations of the brain rhythms (ecb21...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S94
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Feed efficiency is one of the major components determining costs of animal production. Residual feed intake (RFI) is defined as the difference between the observed and the expected feed intake given a certain production. Residual feed intake 1 (RFI1) was calculated based on regression of individual daily fee...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-27
更新日期:2014-02-17 00:00:00
abstract:BACKGROUND:Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least on...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-92
更新日期:2011-10-27 00:00:00
abstract::We compare and contrast the performance of SIMPLE, a Monte Carlo based software, with that of several other methods for linkage and haplotype analyses, focusing on the simulated data from the New York City population. First, a whole-genome scan study based on the microsatellite markers was performed using GENEHUNTER. ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S76
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00913-8
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Typically, the first phase of a genome wide association study (GWAS) includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide ad...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-94
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0177-0
更新日期:2015-02-11 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have crucial roles in various biological regulatory processes. However, the study of lncRNAs is limited in woody plants. Catalpa bungei is a valuable ornamental tree with a long cultivation history in China, and a deeper understanding of the floral transition mechanism in C. bu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0671-2
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:The Mitotic Exit Network (MEN) proteins - including the protein kinase Cdc15 and the protein phosphatase Cdc14 - are essential for exit from mitosis in Saccharomyces cerevisiae. To identify downstream targets of the MEN, we sought telophase arrest bypassed (tab) mutations that bypassed the essential requirem...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-3-4
更新日期:2002-03-12 00:00:00
abstract:BACKGROUND:The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. R...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0323-8
更新日期:2016-01-06 00:00:00
abstract:BACKGROUND:Arterial stiffness is an independent predictor of cardiovascular outcomes in hypertensive patients including myocardial infarction, fatal stroke, cerebral micro-bleeds which predicts cerebral hemorrhage in hypertensive patients, as well as progression to hypertension in non-hypertensive subjects. The associa...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0324-7
更新日期:2016-01-11 00:00:00