Abstract:
BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, Taggar and Nilotic goats. Using the 50 K SNP chip, 24 animals of each breed were genotyped. RESULTS:More than 96% of high quality SNPs were polymorphic with an average minor allele frequency of 0.3. In all breeds, no significant difference between observed (0.4) and expected (0.4) heterozygosity was found and the inbreeding coefficients (FIS) did not differ from zero. Fst coefficients for the genetic distance between breeds also did not significantly deviate from zero. In addition, the analysis of molecular variance revealed that 93% of the total variance in the examined population can be explained by differences among individuals, while only 7% result from differences between the breeds. These findings provide evidence for high genetic diversity and little inbreeding within breeds on one hand, and low diversity between breeds on the other hand. Further examinations using Nei's genetic distance and STRUCTURE analysis clustered Taggar goats distinct from the other breeds. In a principal component (PC) analysis, PC1 could separate Taggar, Nilotic and a mix of Nubian and Desert goats into three groups. The SNPs that contributed strongly to PC1 showed high Fst values in Taggar goat versus the other goat breeds. PCA allowed us to identify target genomic regions which contain genes known to influence growth, development, bone formation and the immune system. CONCLUSIONS:The information on the genetic variability and diversity in this study confirmed that Taggar goat is genetically different from the other goat breeds in Sudan. The SNPs identified by the first principal components show high Fst values in Taggar goat and allowed to identify candidate genes which can be used in the development of breed selection programs to improve local breeds and find genetic factors contributing to the adaptation to harsh environments.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Rahmatalla SA,Arends D,Reissmann M,Said Ahmed A,Wimmers K,Reyer H,Brockmann GAdoi
10.1186/s12863-017-0553-zsubject
Has Abstractpub_date
2017-10-23 00:00:00pages
92issue
1issn
1471-2156pii
10.1186/s12863-017-0553-zjournal_volume
18pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0716-1
更新日期:2019-01-25 00:00:00
abstract:BACKGROUND:Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study, we aimed to identify major QTLs for kernel length, as well as putative candidate genes that migh...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0438-6
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our re...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0319-4
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0351-z
更新日期:2016-02-13 00:00:00
abstract:BACKGROUND:The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly fo...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0134-3
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Patellar luxation is an orthopedic disorder in which the patella moves out of its normal location within the femoral trochlea of the knee and it can lead to osteoarthritis, lameness, and pain. In dogs it is a heritable trait, with both environmental and genetic factors contributing to the phenotype. The prev...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-64
更新日期:2014-05-28 00:00:00
abstract::The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S104
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Cigarette smoking behavior may have a genetic basis. We assessed evidence for quantitative trait loci (QTLs) affecting the maximum number of cigarettes smoked per day, a trait meant to quantify this behavior, using data collected over 40 years as part of the Framingham Heart Study's original and offspring co...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S102
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. Oculocutaneous albinism was studied in a herd of Murrah buffalo to determine the clinical presentation and genetic basis of albinism in this species. RESULTS:Clinical e...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-62
更新日期:2012-07-20 00:00:00
abstract:BACKGROUND:Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. This study was designed to identify m...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0338-9
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity detected in our sample. We performed a mutation screen in 93 extremely obese children and adolescents...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-17
更新日期:2007-05-03 00:00:00
abstract:BACKGROUND:Genome-wide investigation of molecular mechanisms for high-altitude adaptation has attracted great attention in the last few years. In order to understand the contribution of gene expression level variations to high-altitude adaptation in Asiatic toads (Bufo gargarizans), we implemented a reciprocal transpla...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0529-z
更新日期:2017-07-03 00:00:00
abstract::The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S12
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Genome-wide association studies involve detecting association between millions of genetic variants and a trait, which typically use univariate regression to test association between each single variant and the phenotype. Alternatively, Lasso penalized regression allows one to jointly model the relationship b...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0533-3
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of the Drosophila CNS is frequently achieved by employing the binary Gal4/UAS system...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00895-7
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine chromosome 14 (BTA14) tog...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-45
更新日期:2008-07-08 00:00:00
abstract:BACKGROUND:There are at least 25 human selenoproteins, each characterized by the incorporation of selenium into the primary sequence as the amino acid selenocysteine. Since many selenoproteins have antioxidant properties, it is plausible that inter-individual differences in selenoprotein expression or activity could in...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-7-56
更新日期:2006-12-11 00:00:00
abstract::We present a new method for fine-mapping a disease susceptibility locus using a case-control design. The new method, termed the weighted average (WA) statistic, averages the Cochran-Armitage (CA) trend test statistic and the difference between the Hardy-Weinberg disequilibrium test statistic for cases and controls (th...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S67
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Yami and Ivatan islanders are Austronesian speakers from Orchid Island and the Batanes archipelago that are located between Taiwan and the Philippines. The paternal genealogies of the Yami tribe from 1962 monograph of Wei and Liu were compared with our dataset of non-recombining Y (NRY) chromosomes from the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-21
更新日期:2011-01-31 00:00:00
abstract::Genome read categorization determines the genome of origin for sequence reads from an allopolyploid organism. Different techniques have been used to perform read categorization, mostly based on homoeo-SNPs identified between extant diploid relatives of allopolyploids. We present a novel technique for read categorizati...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-16-S2-S4
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0467-1
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:The monocyte chemoattractant protein 1 (MCP-1) is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-34
更新日期:2011-04-19 00:00:00
abstract:BACKGROUND:Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have only a single copy. DNA sequence comparisons with other rodents with multiple Sry copies are incon...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-11
更新日期:2007-04-04 00:00:00
abstract:BACKGROUND:Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported a...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0172-5
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00889-5
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Reniform nematode (Rotylenchulus reniformis) has emerged as one of the most destructive root pathogens of upland cotton (Gossypium hirsutum) in the United States. Management of R. reniformis has been hindered by the lack of resistant G. hirsutum cultivars; however, resistance has been frequently identified i...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0662-3
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Phenotype error causes reduction in power to detect genetic association. We present a quantification of phenotype error, also known as diagnostic error, on power and sample size calculations for case-control genetic association studies between a marker locus and a disease phenotype. We consider the classic P...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-18
更新日期:2005-04-08 00:00:00
abstract:BACKGROUND:The cultivated peanut (Arachis hypogaea L.) is an important oil and food crop in the world. Pod- and kernel-related traits are direct factors involved in determining the yield of the peanut. However, the genetic basis underlying pod- and kernel-related traits in the peanut remained largely unknown, which ham...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0337-x
更新日期:2016-01-25 00:00:00
abstract:BACKGROUND:Nucleotide 1311 polymorphism at exon 11 of G6PD gene is widely prevalent in various populations of the world. The aim of the study was to evaluate 1311 polymorphism in subjects carrying G6PD Mediterranean gene and in general population living in Pakistan. RESULTS:Patients already known to be G6PD deficient ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-41
更新日期:2009-07-30 00:00:00
abstract:BACKGROUND:This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0181-4
更新日期:2015-02-28 00:00:00