Abstract:
:The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and evidence for linkage to change in systolic blood pressure (SBP) over time. We used Gibbs sampling to derive sigma-squared-A-random-effects (SSARs) for the longitudinal phenotype, and then used these as a new phenotype in subsequent genome-wide linkage analyses. Additive genetic effects (sigma2A.time) were estimated to account for approximately 9.2% of the variance in the rate of change of SBP with age, while additive genetic effects (sigma2A) were estimated to account for approximately 43.9% of the variance in SBP at the mean age. The linkage results suggested that one or more major loci regulating change in SBP over time may localize to chromosomes 2, 3, 4, 6, 10, 11, 17, and 19. The results also suggested that one or more major loci regulating level of SBP may localize to chromosomes 3, 8, and 14. Our results support a genetic component to both SBP and change in SBP with age, and are consistent with a complex, multifactorial susceptibility to the development of hypertension. The use of SSARs derived from quantitative traits as input to a conventional linkage analysis appears to be valuable in the linkage analysis of genetically complex traits. We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Palmer LJ,Scurrah KJ,Tobin M,Patel SR,Celedon JC,Burton PR,Weiss STdoi
10.1186/1471-2156-4-S1-S12keywords:
subject
Has Abstractpub_date
2003-12-31 00:00:00pages
S12issn
1471-2156pii
1471-2156-4-S1-S12journal_volume
4 Suppl 1pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-18
更新日期:2007-05-04 00:00:00
abstract::The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study this question, two types of covariate models were used in the simulated Genetic Analysis Workshop 14 dataset i...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S49
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:The current genetic structure of Iberian populations has presumably been affected by the complex orography of its territory, the different people and civilizations that settled there, its ancient and complex history, the diverse and persistent sociocultural patterns in its different regions, and also by the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-37
更新日期:2007-06-27 00:00:00
abstract:BACKGROUND:Fenofibrate (Fb) is a known treatment for elevated triglyceride (TG) levels. The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study was designed to investigate potential contributors to the effects of Fb on TG levels. Here, we summarize the analyses of 8 papers whose authors had access to the GO...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0652-5
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0467-1
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0148-x
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:Sesame (Sesamum indicum L.) is one of the four major oil crops in China. A sesame core collection (CC) was established in China in 2000, but no complete study on its genetic diversity has been carried out at either the phenotypic or molecular level. To provide technical guidance, a theoretical basis for furt...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-102
更新日期:2012-11-15 00:00:00
abstract::Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S21
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Typically, the first phase of a genome wide association study (GWAS) includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide ad...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-94
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Cytoplasmic effects on agronomic traits--involving cytoplasmic and nuclear genomes of either different species or different cultivars--are well documented in wheat but have seldom been demonstrated in rice (Oryza sativa L.). To detect cytoplasmic effects, we introgressed the nuclear genomes of three indica c...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-53
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:In cross breeding, it is important to choose a good parental combination that has high probability of generating offspring with desired characteristics. This study examines a method for predicting the segregation of target traits in a progeny population based on genome-wide markers and phenotype data of pare...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-81
更新日期:2013-09-12 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously reported that most individuals with CFEOM1 and rare individuals with CFEOM3 harbor heterozygous mutatio...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-26
更新日期:2007-05-18 00:00:00
abstract:BACKGROUND:Spotted wilt caused by tomato spotted wilt virus (TSWV) is one of the major peanut (Arachis hypogaea L.) diseases in the southeastern United States. Occurrence, severity, and symptoms of spotted wilt disease are highly variable from season to season, making it difficult to efficiently evaluate breeding popul...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0435-9
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. RESULTS:Candidate genetic loci associated with habitual coffee consumption were searched within...
journal_title:BMC genetics
pub_type: 杂志文章,meta分析
doi:10.1186/s12863-019-0763-7
更新日期:2019-07-26 00:00:00
abstract:BACKGROUND:Linkage disequilibrium (LD) mapping is commonly used to evaluate markers for genome-wide association studies. Most types of LD software focus strictly on LD analysis and visualization, but lack supporting services for genotyping. RESULTS:We developed a freeware called LD2SNPing, which provides a complete pa...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-26
更新日期:2009-06-06 00:00:00
abstract:BACKGROUND:Koala (Koa) is a dominant mutation in mice causing bushy muzzle and pinna, and is associated with a chromosomal inversion on the distal half of chromosome 15. To identify the gene responsible for the Koa phenotypes, we investigated phenotypes of Koa homozygous mice and determined the breakpoints of the inver...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-60
更新日期:2009-09-22 00:00:00
abstract:BACKGROUND:Wheat leaf rust is an important disease worldwide. Understanding the pathogenic molecular mechanism of Puccinia triticina Eriks. (Pt) and the inconstant toxic region is critical for managing the disease. The present study aimed to analyze the pathogenic divergence between Pt isolates. RESULTS:Total RNA was ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00851-5
更新日期:2020-04-28 00:00:00
abstract:BACKGROUND:Drought is one of the most important abiotic stresses that cause drastic reduction in rice grain yield (GY) in rainfed environments. The identification and introgression of QTL leading to high GY under drought have been advocated to be the preferred breeding strategy to improve drought tolerance of popular r...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-63
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-21
更新日期:2008-02-27 00:00:00
abstract:BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0716-1
更新日期:2019-01-25 00:00:00
abstract:BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-8
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-73
更新日期:2008-11-18 00:00:00
abstract:BACKGROUND:Haematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especiall...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-56
更新日期:2010-06-28 00:00:00
abstract::Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three populations AI, KA, and DA but with large differences in significance levels. These differences in results may be ex...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S140
更新日期:2005-12-30 00:00:00
abstract::Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S82
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Peach [Prunus persica (L.) Batsch] is one of the most economically important fruit crops that, due to its genetic and biological characteristics (small genome size, taxonomic proximity to other important species and short juvenile period), has become a model plant in genomic studies of fruit trees. Our aim w...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-69
更新日期:2010-07-20 00:00:00
abstract:BACKGROUND:Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease. Three in-bred strains of rats, WKY, SHR and SHRSP, are known to be sitosterolemi...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-40
更新日期:2005-07-18 00:00:00
abstract:BACKGROUND:Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been reported in the past few years. Most of the quantitative trait loci (QTLs) for GY under drought in rice r...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-89
更新日期:2011-10-18 00:00:00
abstract::Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing data for polygenic models using family data. The imputation schemes take into account familial relationships a...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S42
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:RNA sequencing (RNA-seq) technology has identified multiple differentially expressed (DE) genes associated to complex disease, however, these genes only explain a modest part of variance. Omnigenic model assumes that disease may be driven by genes with indirect relevance to disease and be propagated by funct...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0739-7
更新日期:2019-03-19 00:00:00