Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues.

abstract：BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...

journal_title：BMC genetics

authors： Chen X,Wang J,Hou X,Yue W,Huang S,Wang C

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome. RESULTS:We isolated 11 lethal lines that map...

journal_title：BMC genetics

authors： Boles MK,Wilkinson BM,Maxwell A,Lai L,Mills AA,Nishijima I,Salinger AP,Moskowitz I,Hirschi KK,Liu B,Bradley A,Justice MJ

更新日期：2009-03-06 00:00:00

abstract：BACKGROUND:Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported a...

journal_title：BMC genetics

authors： Chen H,Xu J,Zhou Y,Gao Y,Wang G,Xia J,Huen MS,Siok WT,Jiang Y,Tan LH,Sun Y

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection agains...

journal_title：BMC genetics

authors： Lewis TW,Blott SC,Woolliams JA

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Retinal function is ordered by interactions between transcriptional and posttranscriptional regulators at the molecular level. These regulators include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs). Some studies propose that miRs predominantly target the TFs rather than...

journal_title：BMC genetics

authors： Andreeva K,Soliman MM,Cooper NG

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Nucleotide 1311 polymorphism at exon 11 of G6PD gene is widely prevalent in various populations of the world. The aim of the study was to evaluate 1311 polymorphism in subjects carrying G6PD Mediterranean gene and in general population living in Pakistan. RESULTS:Patients already known to be G6PD deficient ...

journal_title：BMC genetics

authors： Moiz B,Nasir A,Moatter T,Naqvi ZA,Khurshid M

更新日期：2009-07-30 00:00:00

abstract：BACKGROUND:The disease gene of fragile X syndrome, FMR1 gene, encodes fragile X mental retardation protein (FMRP). The alternative splicing (AS) of FMR1 can affect the structure and function of FMRP. However, the biological functions of alternatively spliced isoforms remain elusive. In a previous study, we identified a...

journal_title：BMC genetics

authors： Yang WJ,Yan AZ,Xu YJ,Guo XY,Fu XG,Li D,Liao J,Zhang D,Lan FH

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Spotted wilt caused by tomato spotted wilt virus (TSWV) is one of the major peanut (Arachis hypogaea L.) diseases in the southeastern United States. Occurrence, severity, and symptoms of spotted wilt disease are highly variable from season to season, making it difficult to efficiently evaluate breeding popul...

journal_title：BMC genetics

authors： Tseng YC,Tillman BL,Peng Z,Wang J

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Genomic selection exploits dense genome-wide marker data to predict breeding values. In this study we used a large sugar beet population of 924 lines representing different germplasm types present in breeding populations: unselected segregating families and diverse lines from more advanced stages of selectio...

journal_title：BMC genetics

authors： Würschum T,Reif JC,Kraft T,Janssen G,Zhao Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Japanese Black cattle are a beef breed whose meat is well known to excel in meat quality, especially in marbling, and whose effective population size is relatively low in Japan. Unlike dairy cattle, the accuracy of genomic evaluation (GE) for carcass traits in beef cattle, including this breed, has been poor...

journal_title：BMC genetics

authors： Ogawa S,Matsuda H,Taniguchi Y,Watanabe T,Nishimura S,Sugimoto Y,Iwaisaki H

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Two key questions in understanding the genetic control of behaviors are: what genes are involved and how these genes interact. To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. RESULTS:We studied 69 genes whose ...

journal_title：BMC genetics

authors： Aleman-Meza B,Loeza-Cabrera M,Peña-Ramos O,Stern M,Zhong W

更新日期：2017-05-12 00:00:00

abstract：:We performed a bivariate analysis on cholesterol and triglyceride levels on data from the Framingham Heart Study using a new score statistic developed for the detection of potential pleiotropic, or cluster, genes. Univariate score statistics were also computed for each trait. At a significance level 0.001, linkage sig...

journal_title：BMC genetics

authors： Zhang X,Wang K,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：:A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...

journal_title：BMC genetics

authors： Lemire M

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Neuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and coding regions of the bovine NPY gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle. The obje...

journal_title：BMC genetics

authors： Bahar B,Sweeney T

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Grasslands in the Arctic tundra undergo irreversible degradation due to climatic changes and also over-exploitation and depletion of scarce resources. Comprehensive investigations of cytogenomic structures of valuable Arctic and sub-Arctic grassland species is essential for clarifying their genetic peculiari...

journal_title：BMC genetics

authors： Amosova AV,Zoshchuk SA,Rodionov AV,Ghukasyan L,Samatadze TE,Punina EO,Loskutov IG,Yurkevich OY,Muravenko OV

更新日期：2019-12-04 00:00:00

abstract：:The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study this question, two types of covariate models were used in the simulated Genetic Analysis Workshop 14 dataset i...

journal_title：BMC genetics

authors： Bailey JN

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Growth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accurate prediction of breeding values of animals without own phenotypic information. This study investiga...

journal_title：BMC genetics

authors： Liu T,Qu H,Luo C,Shu D,Wang J,Lund MS,Su G

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Structured association mapping is proving to be a powerful strategy to find genetic polymorphisms associated with disease. However, these algorithms are often distributed as command line implementations that require expertise and effort to customize and put into practice. Because of the difficulty required t...

journal_title：BMC genetics

authors： Curtis RE,Goyal A,Xing EP

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...

journal_title：BMC genetics

authors： Goryca K,Kulecka M,Paziewska A,Dabrowska M,Grzelak M,Skrzypczak M,Ginalski K,Mroz A,Rutkowski A,Paczkowska K,Mikula M,Ostrowski J

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...

journal_title：BMC genetics

authors： Sica M,Gamba G,Montieri S,Gaudio L,Aceto S

更新日期：2005-03-18 00:00:00

abstract：:The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted ...

journal_title：BMC genetics

authors： Brown WM,Beck SR,Lange EM,Davis CC,Kay CM,Langefeld CD,Rich SS,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...

journal_title：BMC genetics

authors： Taye M,Kim J,Yoon SH,Lee W,Hanotte O,Dessie T,Kemp S,Mwai OA,Caetano-Anolles K,Cho S,Oh SJ,Lee HK,Kim H

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:The Mitotic Exit Network (MEN) proteins - including the protein kinase Cdc15 and the protein phosphatase Cdc14 - are essential for exit from mitosis in Saccharomyces cerevisiae. To identify downstream targets of the MEN, we sought telophase arrest bypassed (tab) mutations that bypassed the essential requirem...

journal_title：BMC genetics

authors： Shou W,Deshaies RJ

更新日期：2002-03-12 00:00:00

abstract：BACKGROUND:Relatively little information is available for sequence variation in the pig. We previously used a combination of short read (25 base pair) high-throughput sequencing and reduced genomic representation to discover > 60,000 single nucleotide polymorphisms (SNP) in cattle, but the current lack of complete geno...

journal_title：BMC genetics

authors： Wiedmann RT,Smith TP,Nonneman DJ

更新日期：2008-12-04 00:00:00

abstract：BACKGROUND:There are at least 25 human selenoproteins, each characterized by the incorporation of selenium into the primary sequence as the amino acid selenocysteine. Since many selenoproteins have antioxidant properties, it is plausible that inter-individual differences in selenoprotein expression or activity could in...

journal_title：BMC genetics

authors： Foster CB,Aswath K,Chanock SJ,McKay HF,Peters U

更新日期：2006-12-11 00:00:00

abstract：BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...

journal_title：BMC genetics

authors： Thutkawkorapin J,Picelli S,Kontham V,Liu T,Nilsson D,Lindblom A

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:In cross breeding, it is important to choose a good parental combination that has high probability of generating offspring with desired characteristics. This study examines a method for predicting the segregation of target traits in a progeny population based on genome-wide markers and phenotype data of pare...

journal_title：BMC genetics

authors： Iwata H,Hayashi T,Terakami S,Takada N,Saito T,Yamamoto T

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

journal_title：BMC genetics

authors： Hussey DJ,Moore S,Nicola M,Dobrovic A

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Transgenic poplar (Populus × euramericana 'Guariento') plants harboring five exogenous, stress-related genes exhibit increased tolerance to multiple stresses including drought, salt, waterlogging, and insect feeding, but the complex mechanisms underlying stress tolerance in these plants have not been elucida...

journal_title：BMC genetics

authors： Zhang W,Chu Y,Ding C,Zhang B,Huang Q,Hu Z,Huang R,Tian Y,Su X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in multiple epithelia during later development. Both insertions caused recessive mutations that r...

journal_title：BMC genetics

authors： Serth K,Beckers A,Schuster-Gossler K,Pavlova MN,Müller J,Paul MC,Reinhardt R,Gossler A

更新日期：2015-12-18 00:00:00