SNP discovery in swine by reduced representation and high throughput pyrosequencing.

abstract：BACKGROUND:We analyzed 143 pedigrees (364 nuclear families) in the Collaborative Study on the Genetics of Alcoholism (COGA) data provided to the participants in the Genetic Analysis Workshop 14 (GAW14) with the goal of comparing results obtained from genome linkage analysis using microsatellite and with results obtaine...

journal_title：BMC genetics

authors： Chen G,Adeyemo A,Zhou J,Yuan A,Chen Y,Rotimi C

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Non-invasive sampling has opened avenues for the genetic study of elusive species, which has contributed significantly to their conservation. Where field based identity of non-invasive sample is ambiguous (e.g. carnivore scats), it is essential to establish identity of the species through molecular approache...

journal_title：BMC genetics

authors： Maroju PA,Yadav S,Kolipakam V,Singh S,Qureshi Q,Jhala Y

更新日期：2016-02-09 00:00:00

abstract：:The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...

journal_title：BMC genetics

authors： Liu X,Jorgenson E,Witte JS

更新日期：2005-12-30 00:00:00

abstract：:Genotype data from the Illumina Linkage III SNP panel (n = 4,720 SNPs) and the Affymetrix 10 k mapping array (n = 11,120 SNPs) were used to test the effects of linkage disequilibrium (LD) between SNPs in a linkage analysis in the Collaborative Study on the Genetics of Alcoholism pedigree collection (143 pedigrees; 1,6...

journal_title：BMC genetics

authors： Murray SS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly fo...

journal_title：BMC genetics

authors： Ouhaibi-Djellouli H,Mediene-Benchekor S,Lardjam-Hetraf SA,Hamani-Medjaoui I,Meroufel DN,Boulenouar H,Hermant X,Saidi-Mehtar N,Amouyel P,Houti L,Goumidi L,Meirhaeghe A

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:Hybrid breakdown has been well documented in various species. Relationships between genomic heterozygosity and traits-fitness have been extensively explored especially in the natural populations. But correlations between genomic heterozygosity and vegetative and reproductive traits in cotton interspecific po...

journal_title：BMC genetics

authors： Dai B,Guo H,Huang C,Zhang X,Lin Z

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

journal_title：BMC genetics

authors： Hussey DJ,Moore S,Nicola M,Dobrovic A

更新日期：2001-01-01 00:00:00

abstract：:A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...

journal_title：BMC genetics

authors： Yang HC,Chang CC,Lin CY,Chen CL,Lin CY,Fann CS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The SNF3 gene in the yeast Saccharomyces cerevisiae encodes a low glucose sensor that regulates expression of an important subset of the hexose transporter (HXT) superfamily. Null mutations of snf3 result in a defect in growth on low glucose concentrations due to the inability to relieve repression of a subs...

journal_title：BMC genetics

authors： Dietzel KL,Ramakrishnan V,Murphy EE,Bisson LF

更新日期：2012-12-12 00:00:00

abstract：BACKGROUND:The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris ...

journal_title：BMC genetics

authors： Anderson MG,Nair KS,Amonoo LA,Mehalow A,Trantow CM,Masli S,John SW

更新日期：2008-04-10 00:00:00

abstract：BACKGROUND:Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) as associated with colorectal cancer (CRC) risk in populations of European descent. However, their utility for predicting risk to CRC in Asians remains unknown. A case-cohort study (random sub-cohort N=1,685) from...

journal_title：BMC genetics

authors： Jung KJ,Won D,Jeon C,Kim S,Kim TI,Jee SH,Beaty TH

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Congenital heart defects (CHD) is the most common cause of death from a congenital structure abnormality in newborns and is often associated with fetal loss. There are many types of CHD. Human genetic studies have identified genes that are responsible for the inheritance of a particular type of CHD and for s...

journal_title：BMC genetics

authors： Flaquer A,Baumbach C,Piñero E,García Algas F,de la Fuente Sanchez MA,Rosell J,Toquero J,Alonso-Pulpon L,Garcia-Pavia P,Strauch K,Heine-Suñer D

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Plant calmodulin-binding transcription activator (CAMTA) proteins play important roles in hormone signal transduction, developmental regulation, and environmental stress tolerance. However, in wheat, the CAMTA gene family has not been systematically characterized. RESULTS:In this work, 15 wheat CAMTA genes ...

journal_title：BMC genetics

authors： Yang F,Dong FS,Hu FH,Liu YW,Chai JF,Zhao H,Lv MY,Zhou S

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from unphased ge...

journal_title：BMC genetics

authors： Adkins RM

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...

journal_title：BMC genetics

authors： Woolley SA,Hayes SE,Shariflou MR,Nicholas FW,Willet CE,O'Rourke BA,Tammen I

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...

journal_title：BMC genetics

authors： Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu S

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:Our initial genome-wide association study (GWAS) identified 20 promising candidate genes for milk fatty acid (FA) traits in a Chinese Holstein population, including PRLR, MOGAT1, MINPP1 and CHUK genes. In this study, we performed whether they had significant genetic effects on milk FA traits in Chinese Holst...

journal_title：BMC genetics

authors： Shi L,Liu L,Lv X,Ma Z,Yang Y,Li Y,Zhao F,Sun D,Han B

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:In a deep sequencing analysis of small RNAs prepared from a living fossil, the tadpole shrimp Triops cancriformis, a 32-nt small RNA was specifically detected in the adult stage. A nucleotide sequence comparison between the 32-nt small RNA and predicted tRNA sequences in the draft nuclear genomic DNA showed ...

journal_title：BMC genetics

authors： Hirose Y,Ikeda KT,Noro E,Hiraoka K,Tomita M,Kanai A

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:MUC4 is a type of membrane anchored glycoprotein and serves as the major constituent of mucus that covers epithelial surfaces of many tissues such as trachea, colon and cervix. MUC4 plays important roles in the lubrication and protection of the surface epithelium, cell proliferation and differentiation, immu...

journal_title：BMC genetics

authors： Yang M,Yang B,Yan X,Ouyang J,Zeng W,Ai H,Ren J,Huang L

更新日期：2012-07-13 00:00:00

abstract：BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

journal_title：BMC genetics

authors： Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

更新日期：2007-07-28 00:00:00

abstract：BACKGROUND:Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing. RESULTS:Associations between cognitive ageing and 325 single nucleotide polymorphis...

journal_title：BMC genetics

authors： Harris SE,Fox H,Wright AF,Hayward C,Starr JM,Whalley LJ,Deary IJ

更新日期：2007-07-02 00:00:00

abstract：BACKGROUND:Grass carp (Ctenopharyngodon idellus, GC), as the highest-output fish in China, is economically important. The production of gynogenetic grass carp (GGC) will provide important germplasm resource for producing improved GC. At present, knowledge regarding the heterologous sperm DNA in gynogenetic offspring is...

journal_title：BMC genetics

authors： Mao Z,Fu Y,Wang Y,Wang S,Zhang M,Gao X,Luo K,Qin Q,Zhang C,Tao M,Yao Z,Liu S

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection agains...

journal_title：BMC genetics

authors： Lewis TW,Blott SC,Woolliams JA

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations. RESULTS:Sequence reads from light shot-gun sequencing efforts of different dog breeds were aligned to the dog genome reference sequence and gaps corresponding to indels were identified. One h...

journal_title：BMC genetics

authors： Väli U,Brandström M,Johansson M,Ellegren H

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...

journal_title：BMC genetics

authors： Beltram J,Morton NM,Kunej T,Horvat S

更新日期：2016-06-11 00:00:00

abstract：BACKGROUND:The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant da...

journal_title：BMC genetics

authors： Sabbagh A,Langaney A,Darlu P,Gérard N,Krishnamoorthy R,Poloni ES

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a re...

journal_title：BMC genetics

authors： Hernández CL,Dugoujon JM,Novelletto A,Rodríguez JN,Cuesta P,Calderón R

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the association in women is unclear. Since lipid levels vary between the sexes the antioxidant effect of ...

journal_title：BMC genetics

authors： Lawlor DA,Day IN,Gaunt TR,Hinks LJ,Briggs PJ,Kiessling M,Timpson N,Smith GD,Ebrahim S

更新日期：2004-06-23 00:00:00

abstract：BACKGROUND:The plateau pika (Ochotona curzoniae) is an underground-dwelling mammal, native to the Tibetan plateau of China. A set of 10 polymorphic microsatellite loci has been developed earlier. Its reliability for parentage assignment has been tested in a plateau pika population. Two family groups with a known pedigr...

journal_title：BMC genetics

authors： Li K,Geng J,Qu J,Zhang Y,Hu S

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of r...

journal_title：BMC genetics

authors： Naz AA,Arifuzzaman M,Muzammil S,Pillen K,Léon J

更新日期：2014-10-07 00:00:00