Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe.

abstract：BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...

journal_title：BMC genetics

authors： Goryca K,Kulecka M,Paziewska A,Dabrowska M,Grzelak M,Skrzypczak M,Ginalski K,Mroz A,Rutkowski A,Paczkowska K,Mikula M,Ostrowski J

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease. Three in-bred strains of rats, WKY, SHR and SHRSP, are known to be sitosterolemi...

journal_title：BMC genetics

authors： Chen J,Batta A,Zheng S,Fitzgibbon WR,Ullian ME,Yu H,Tso P,Salen G,Patel SB

更新日期：2005-07-18 00:00:00

abstract：BACKGROUND:Sox domain containing genes are important metazoan transcriptional regulators implicated in a wide rage of developmental processes. The vertebrate B subgroup contains the Sox1, Sox2 and Sox3 genes that have early functions in neural development. Previous studies show that Drosophila Group B genes have been f...

journal_title：BMC genetics

authors： McKimmie C,Woerfel G,Russell S

更新日期：2005-05-19 00:00:00

abstract：BACKGROUND:Numerous studies have attempted to relate genetic polymorphisms within the N-acetyltransferase 2 gene (NAT2) to interindividual differences in response to drugs or in disease susceptibility. However, genotyping of individuals single-nucleotide polymorphisms (SNPs) alone may not always provide enough informat...

journal_title：BMC genetics

authors： Sabbagh A,Darlu P

更新日期：2005-06-02 00:00:00

abstract：BACKGROUND:Many QTL studies have two common features: (1) often there is missing marker information, (2) among many markers involved in the biological process only a few are causal. In statistics, the second issue falls under the headings "sparsity" and "causal inference". The goal of this work is to develop a two-step...

journal_title：BMC genetics

authors： Demetrashvili N,Van den Heuvel ER,Wit EC

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with th...

journal_title：BMC genetics

authors： Velie BD,Fegraeus KJ,Solé M,Rosengren MK,Røed KH,Ihler CF,Strand E,Lindgren G

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least on...

journal_title：BMC genetics

authors： Tortereau F,Sanchez MP,Fève K,Gilbert H,Iannuccelli N,Billon Y,Milan D,Bidanel JP,Riquet J

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:Grass carp (Ctenopharyngodon idellus, GC), as the highest-output fish in China, is economically important. The production of gynogenetic grass carp (GGC) will provide important germplasm resource for producing improved GC. At present, knowledge regarding the heterologous sperm DNA in gynogenetic offspring is...

journal_title：BMC genetics

authors： Mao Z,Fu Y,Wang Y,Wang S,Zhang M,Gao X,Luo K,Qin Q,Zhang C,Tao M,Yao Z,Liu S

更新日期：2019-01-07 00:00:00

abstract：:A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...

journal_title：BMC genetics

authors： Yang HC,Chang CC,Lin CY,Chen CL,Lin CY,Fann CS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Transgenic poplar (Populus × euramericana 'Guariento') plants harboring five exogenous, stress-related genes exhibit increased tolerance to multiple stresses including drought, salt, waterlogging, and insect feeding, but the complex mechanisms underlying stress tolerance in these plants have not been elucida...

journal_title：BMC genetics

authors： Zhang W,Chu Y,Ding C,Zhang B,Huang Q,Hu Z,Huang R,Tian Y,Su X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome. RESULTS:We isolated 11 lethal lines that map...

journal_title：BMC genetics

authors： Boles MK,Wilkinson BM,Maxwell A,Lai L,Mills AA,Nishijima I,Salinger AP,Moskowitz I,Hirschi KK,Liu B,Bradley A,Justice MJ

更新日期：2009-03-06 00:00:00

abstract：BACKGROUND:Adaption to cold temperatures, especially those below freezing, is essential for animal survival in cold environments. Freezing is also used for many medical, scientific, and industrial purposes. Natural freezing survival in animals has been extensively studied. However, the underlying mechanisms remain uncl...

journal_title：BMC genetics

authors： Hu JP,Xu XY,Huang LY,Wang LS,Fang NY

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:The SnRKs (sucrose non-fermenting 1 related protein kinase) are a gene family coding for Ser/Thr protein kinases and play important roles in linking the tolerance and metabolic responses of plants to abiotic stresses. To date, no genome-wide characterization of the sucrose non-ferment 1 related protein kinas...

journal_title：BMC genetics

authors： Bai J,Mao J,Yang H,Khan A,Fan A,Liu S,Zhang J,Wang D,Gao H,Zhang J

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...

journal_title：BMC genetics

authors： Biscarini F,Stevanato P,Broccanello C,Stella A,Saccomani M

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Koala (Koa) is a dominant mutation in mice causing bushy muzzle and pinna, and is associated with a chromosomal inversion on the distal half of chromosome 15. To identify the gene responsible for the Koa phenotypes, we investigated phenotypes of Koa homozygous mice and determined the breakpoints of the inver...

journal_title：BMC genetics

authors： Katayama K,Miyamoto S,Furuno A,Akiyama K,Takahashi S,Suzuki H,Tsuji T,Kunieda T

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Genomic selection exploits dense genome-wide marker data to predict breeding values. In this study we used a large sugar beet population of 924 lines representing different germplasm types present in breeding populations: unselected segregating families and diverse lines from more advanced stages of selectio...

journal_title：BMC genetics

authors： Würschum T,Reif JC,Kraft T,Janssen G,Zhao Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Drought is one of the most important abiotic stresses that cause drastic reduction in rice grain yield (GY) in rainfed environments. The identification and introgression of QTL leading to high GY under drought have been advocated to be the preferred breeding strategy to improve drought tolerance of popular r...

journal_title：BMC genetics

authors： Sandhu N,Singh A,Dixit S,Sta Cruz MT,Maturan PC,Jain RK,Kumar A

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present st...

journal_title：BMC genetics

authors： Yao F,Zhang X,Ye X,Li J,Long L,Yu C,Li J,Wang Y,Wu Y,Wang J,Jiang Q,Li W,Ma J,Wei Y,Zheng Y,Chen G

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS:In 2027 participants rando...

journal_title：BMC genetics

authors： Yang WY,Petit T,Thijs L,Zhang ZY,Jacobs L,Hara A,Wei FF,Salvi E,Citterio L,Delli Carpini S,Gu YM,Knez J,Cauwenberghs N,Barcella M,Barlassina C,Manunta P,Coppiello G,Aranguren XL,Kuznetsova T,Cusi D,Verhamme P,Lu

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual's susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder c...

journal_title：BMC genetics

authors： Hou J,Gu Y,Hou W,Wu S,Lou Y,Yang W,Zhu L,Hu Y,Sun M,Xue H

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:The Africanized honey bee is one of the most spectacular invasions in the Americas. African bees escaped from apiaries in Brazil in 1956, spread over Americas and by 1994 they were reported in Puerto Rico. In contrast to other places, the oceanic island conditions in Puerto Rico may mean a single introductio...

journal_title：BMC genetics

authors： Galindo-Cardona A,Acevedo-Gonzalez JP,Rivera-Marchand B,Giray T

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasing over the past few ...

journal_title：BMC genetics

authors： Gajaweera C,Kang JM,Lee DH,Lee SH,Kim YK,Wijayananda HI,Kim JJ,Ha JH,Choi BH,Lee SH

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Two key questions in understanding the genetic control of behaviors are: what genes are involved and how these genes interact. To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. RESULTS:We studied 69 genes whose ...

journal_title：BMC genetics

authors： Aleman-Meza B,Loeza-Cabrera M,Peña-Ramos O,Stern M,Zhong W

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:mRNA expression in a cell or subcellular organelle is precisely regulated for the purpose of gene function regulation. The 3' untranslated region (3'UTR) of mRNA is the binding target of microRNA and RNA binding proteins. Their interactions regulate mRNA level in specific subcellular regions and determine th...

journal_title：BMC genetics

authors： Li T,Kuang Y,Li B

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...

journal_title：BMC genetics

authors： Woolley SA,Hayes SE,Shariflou MR,Nicholas FW,Willet CE,O'Rourke BA,Tammen I

更新日期：2020-09-15 00:00:00

abstract：:We present a new method for fine-mapping a disease susceptibility locus using a case-control design. The new method, termed the weighted average (WA) statistic, averages the Cochran-Armitage (CA) trend test statistic and the difference between the Hardy-Weinberg disequilibrium test statistic for cases and controls (th...

journal_title：BMC genetics

authors： Song K,Orloff MS,Lu Q,Elston RC

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...

journal_title：BMC genetics

authors： Beltram J,Morton NM,Kunej T,Horvat S

更新日期：2016-06-11 00:00:00

abstract：BACKGROUND:Several lines of evidence including allozyme analysis, restriction digest patterns and sequencing of mtDNA as well as mini- and micro-satellite allele frequencies indicate that Atlantic salmon (Salmo salar) from North America and Europe are genetically distinct. These observations are supported by karyotype ...

journal_title：BMC genetics

authors： Lubieniecki KP,Jones SL,Davidson EA,Park J,Koop BF,Walker S,Davidson WS

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confu...

journal_title：BMC genetics

authors： Wang T,Zeng ZB

更新日期：2009-09-04 00:00:00

abstract：BACKGROUND:Selection for grain yield under drought is an efficient criterion for improving the drought tolerance of rice. Recently, some drought-tolerant rice varieties have been developed using this selection criterion and successfully released for cultivation in drought-prone target environments. The process can be m...

journal_title：BMC genetics

authors： Mishra KK,Vikram P,Yadaw RB,Swamy BP,Dixit S,Cruz MT,Maturan P,Marker S,Kumar A

更新日期：2013-02-26 00:00:00