Abstract:
BACKGROUND:Adaption to cold temperatures, especially those below freezing, is essential for animal survival in cold environments. Freezing is also used for many medical, scientific, and industrial purposes. Natural freezing survival in animals has been extensively studied. However, the underlying mechanisms remain unclear. Previous studies demonstrated that animals survive in extremely cold weather by avoiding freezing or controlling the rate of ice-crystal formation in their bodies, which indicates that freezing survival is a passive thermodynamic process. RESULTS:Here, we showed that genetic programming actively promotes freezing survival in Caenorhabditis elegans. We found that daf-2, an insulin/IGF-1 receptor homologue, and loss-of-function enhanced survival during freeze-thaw stress, which required the transcription factor daf-16/FOXO and age-independent target genes. In particular, the freeze-thaw resistance of daf-2(rf) is highly allele-specific and has no correlation with lifespan, dauer formation, or hypoxia stress resistance. CONCLUSIONS:Our results reveal a new function for daf-2 signaling, and, most importantly, demonstrate that genetic programming contributes to freezing survival.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Hu JP,Xu XY,Huang LY,Wang LS,Fang NYdoi
10.1186/s12863-015-0298-5subject
Has Abstractpub_date
2015-12-03 00:00:00pages
139issn
1471-2156pii
10.1186/s12863-015-0298-5journal_volume
16pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:The SNF3 gene in the yeast Saccharomyces cerevisiae encodes a low glucose sensor that regulates expression of an important subset of the hexose transporter (HXT) superfamily. Null mutations of snf3 result in a defect in growth on low glucose concentrations due to the inability to relieve repression of a subs...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-107
更新日期:2012-12-12 00:00:00
abstract:BACKGROUND:The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly fo...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0134-3
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-13
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:Late embryogenesis abundant (LEA) proteins are large groups of hydrophilic proteins with major role in drought and other abiotic stresses tolerance in plants. In-depth study and characterization of LEA protein families have been carried out in other plants, but not in upland cotton. The main aim of this rese...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0596-1
更新日期:2018-01-15 00:00:00
abstract::Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...
journal_title:BMC genetics
pub_type: 社论
doi:10.1186/1471-2156-7-23
更新日期:2006-04-21 00:00:00
abstract:BACKGROUND:Retinal function is ordered by interactions between transcriptional and posttranscriptional regulators at the molecular level. These regulators include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs). Some studies propose that miRs predominantly target the TFs rather than...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0201-4
更新日期:2015-04-24 00:00:00
abstract:BACKGROUND:We previously conducted a genome-wide association study (GWAS) strategy for milk fatty acids in Chinese Holstein, and identified 83 genome-wide significant single nucleotide polymorphisms (SNPs) and 314 suggestive significant SNPs. Among them, two SNPs, BTB-01077939 and BTA-11275-no-rs associated with C10:0,...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0755-7
更新日期:2019-07-03 00:00:00
abstract:BACKGROUND:Acipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of numerous microchromosomes and propensity to interspecific hybridiz...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0484-8
更新日期:2017-03-02 00:00:00
abstract:BACKGROUND:Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-17
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:mRNA expression in a cell or subcellular organelle is precisely regulated for the purpose of gene function regulation. The 3' untranslated region (3'UTR) of mRNA is the binding target of microRNA and RNA binding proteins. Their interactions regulate mRNA level in specific subcellular regions and determine th...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0417-y
更新日期:2016-07-29 00:00:00
abstract:BACKGROUND:Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-52
更新日期:2009-09-04 00:00:00
abstract:BACKGROUND:Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0754-8
更新日期:2019-07-12 00:00:00
abstract:BACKGROUND:Grass carp (Ctenopharyngodon idellus, GC), as the highest-output fish in China, is economically important. The production of gynogenetic grass carp (GGC) will provide important germplasm resource for producing improved GC. At present, knowledge regarding the heterologous sperm DNA in gynogenetic offspring is...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0712-x
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:Association mapping studies offer great promise to identify polymorphisms associated with phenotypes and for understanding the genetic basis of quantitative trait variation. To date, almost all association mapping studies based on structured plant populations examined the main effects of genetic factors on t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-3
更新日期:2014-01-06 00:00:00
abstract:BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-107
更新日期:2010-12-07 00:00:00
abstract::Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three populations AI, KA, and DA but with large differences in significance levels. These differences in results may be ex...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S140
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Peach [Prunus persica (L.) Batsch] is one of the most economically important fruit crops that, due to its genetic and biological characteristics (small genome size, taxonomic proximity to other important species and short juvenile period), has become a model plant in genomic studies of fruit trees. Our aim w...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-69
更新日期:2010-07-20 00:00:00
abstract:BACKGROUND:Body size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We per...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-0837-6
更新日期:2020-03-14 00:00:00
abstract:BACKGROUND:Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least on...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-92
更新日期:2011-10-27 00:00:00
abstract:BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0467-1
更新日期:2017-02-09 00:00:00
abstract::The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S12
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current toba...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-78
更新日期:2014-06-27 00:00:00
abstract::An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance components-based linkage analysis. On the examined simulated, error-free data...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S72
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annota...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0381-6
更新日期:2016-06-11 00:00:00
abstract:BACKGROUND:Sox domain containing genes are important metazoan transcriptional regulators implicated in a wide rage of developmental processes. The vertebrate B subgroup contains the Sox1, Sox2 and Sox3 genes that have early functions in neural development. Previous studies show that Drosophila Group B genes have been f...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-26
更新日期:2005-05-19 00:00:00
abstract:BACKGROUND:Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of r...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0107-6
更新日期:2014-10-07 00:00:00
abstract:BACKGROUND:Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. RESULTS:Candidate genetic loci associated with habitual coffee consumption were searched within...
journal_title:BMC genetics
pub_type: 杂志文章,meta分析
doi:10.1186/s12863-019-0763-7
更新日期:2019-07-26 00:00:00
abstract::A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-genome linkage and confirmation analyses, single locus and haplotype fine mapping analyses, and gene x environme...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S30
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-8
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00905-8
更新日期:2020-09-01 00:00:00