Statistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies.

abstract：BACKGROUND:The plateau pika (Ochotona curzoniae) is an underground-dwelling mammal, native to the Tibetan plateau of China. A set of 10 polymorphic microsatellite loci has been developed earlier. Its reliability for parentage assignment has been tested in a plateau pika population. Two family groups with a known pedigr...

journal_title：BMC genetics

authors： Li K,Geng J,Qu J,Zhang Y,Hu S

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00

abstract：:Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...

journal_title：BMC genetics

authors： Jacobs KB,Gray-McGuire C,Cartier KC,Elston RC

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types and subtypes of the Drosophila CNS is frequently achieved by employing the binary Gal4/UAS system...

journal_title：BMC genetics

authors： Ogienko AA,Andreyeva EN,Omelina ES,Oshchepkova AL,Pindyurin AV

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...

journal_title：BMC genetics

authors： Rahmatalla SA,Arends D,Reissmann M,Said Ahmed A,Wimmers K,Reyer H,Brockmann GA

更新日期：2017-10-23 00:00:00

abstract：:Participants in the family-based analysis group at Genetic Analysis Workshop 19 addressed diverse topics, all of which used the family data. Topics addressed included questions of study design and data quality control (QC), genotype imputation to augment available sequence data, and linkage and/or association analyses...

journal_title：BMC genetics

authors： Wijsman EM

更新日期：2016-02-03 00:00:00

abstract：:Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...

journal_title：BMC genetics

authors： Papachristou C,Lin S

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Land plants have evolved several measures to maintain their life against abiotic stresses. The accumulation of proline is the most generalized response of plants under drought, heat or salt stress conditions. It is known as an osmoprotectant which also acts as an instant source of energy during drought recov...

journal_title：BMC genetics

authors： Sayed MA,Schumann H,Pillen K,Naz AA,Léon J

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:There are at least 25 human selenoproteins, each characterized by the incorporation of selenium into the primary sequence as the amino acid selenocysteine. Since many selenoproteins have antioxidant properties, it is plausible that inter-individual differences in selenoprotein expression or activity could in...

journal_title：BMC genetics

authors： Foster CB,Aswath K,Chanock SJ,McKay HF,Peters U

更新日期：2006-12-11 00:00:00

abstract：BACKGROUND:Yami and Ivatan islanders are Austronesian speakers from Orchid Island and the Batanes archipelago that are located between Taiwan and the Philippines. The paternal genealogies of the Yami tribe from 1962 monograph of Wei and Liu were compared with our dataset of non-recombining Y (NRY) chromosomes from the ...

journal_title：BMC genetics

authors： Loo JH,Trejaut JA,Yen JC,Chen ZS,Lee CL,Lin M

更新日期：2011-01-31 00:00:00

abstract：BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...

journal_title：BMC genetics

authors： Hothorn LA,Libiger O,Gerhard D

更新日期：2012-07-18 00:00:00

abstract：:Genotype data from the Illumina Linkage III SNP panel (n = 4,720 SNPs) and the Affymetrix 10 k mapping array (n = 11,120 SNPs) were used to test the effects of linkage disequilibrium (LD) between SNPs in a linkage analysis in the Collaborative Study on the Genetics of Alcoholism pedigree collection (143 pedigrees; 1,6...

journal_title：BMC genetics

authors： Murray SS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:We analyzed 143 pedigrees (364 nuclear families) in the Collaborative Study on the Genetics of Alcoholism (COGA) data provided to the participants in the Genetic Analysis Workshop 14 (GAW14) with the goal of comparing results obtained from genome linkage analysis using microsatellite and with results obtaine...

journal_title：BMC genetics

authors： Chen G,Adeyemo A,Zhou J,Yuan A,Chen Y,Rotimi C

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. Oculocutaneous albinism was studied in a herd of Murrah buffalo to determine the clinical presentation and genetic basis of albinism in this species. RESULTS:Clinical e...

journal_title：BMC genetics

authors： Damé MC,Xavier GM,Oliveira-Filho JP,Borges AS,Oliveira HN,Riet-Correa F,Schild AL

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare vascular disorder characterized by a capillary wedge pressure ≤ 15 mmHg and a mean pulmonary arterial pressure ≥ 25 mmHg at rest. PAH can be idiopathic, heritable or associated with other conditions. The aim of this study was to analyze the Endoglin (ENG) gene ...

journal_title：BMC genetics

authors： Pousada G,Baloira A,Fontán D,Núñez M,Valverde D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:MUC4 is a type of membrane anchored glycoprotein and serves as the major constituent of mucus that covers epithelial surfaces of many tissues such as trachea, colon and cervix. MUC4 plays important roles in the lubrication and protection of the surface epithelium, cell proliferation and differentiation, immu...

journal_title：BMC genetics

authors： Yang M,Yang B,Yan X,Ouyang J,Zeng W,Ai H,Ren J,Huang L

更新日期：2012-07-13 00:00:00

abstract：BACKGROUND:The current genetic structure of Iberian populations has presumably been affected by the complex orography of its territory, the different people and civilizations that settled there, its ancient and complex history, the diverse and persistent sociocultural patterns in its different regions, and also by the ...

journal_title：BMC genetics

authors： Calderón R,Lodeiro R,Varela TA,Fariña J,Ambrosio B,Guitard E,González-Martín A,Dugoujon JM

更新日期：2007-06-27 00:00:00

abstract：BACKGROUND:Grasslands in the Arctic tundra undergo irreversible degradation due to climatic changes and also over-exploitation and depletion of scarce resources. Comprehensive investigations of cytogenomic structures of valuable Arctic and sub-Arctic grassland species is essential for clarifying their genetic peculiari...

journal_title：BMC genetics

authors： Amosova AV,Zoshchuk SA,Rodionov AV,Ghukasyan L,Samatadze TE,Punina EO,Loskutov IG,Yurkevich OY,Muravenko OV

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Structured association mapping is proving to be a powerful strategy to find genetic polymorphisms associated with disease. However, these algorithms are often distributed as command line implementations that require expertise and effort to customize and put into practice. Because of the difficulty required t...

journal_title：BMC genetics

authors： Curtis RE,Goyal A,Xing EP

更新日期：2012-04-03 00:00:00

abstract：:The Framingham Heart Study offspring cohort, a complex data set with irregularly spaced longitudinal phenotype data, was made available as part of Genetic Analysis Workshop 13. To allow an analysis of all of the data simultaneously, a mixed-model- based random-regression (RR) approach was used. The RR accounted for th...

journal_title：BMC genetics

authors： Macgregor S,Knott SA,White I,Visscher PM,Framingham Heart Study.

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...

journal_title：BMC genetics

authors： Fernández AI,Muñoz M,Alves E,Folch JM,Noguera JL,Enciso MP,Rodríguez Mdel C,Silió L

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Sry is a gene known to be essential for testis determination but is also transcribed in adult male tissues. The laboratory rat, Rattus norvegicus, has multiple Y chromosome copies of Sry while most mammals have only a single copy. DNA sequence comparisons with other rodents with multiple Sry copies are incon...

journal_title：BMC genetics

authors： Turner ME,Martin C,Martins AS,Dunmire J,Farkas J,Ely DL,Milsted A

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...

journal_title：BMC genetics

authors： Chen X,Wang J,Hou X,Yue W,Huang S,Wang C

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. This study was designed to identify m...

journal_title：BMC genetics

authors： Kim BY,Jin H,Lee YJ,Kang GY,Cho J,Lee YS

更新日期：2016-01-27 00:00:00

abstract：:We compare and contrast the performance of SIMPLE, a Monte Carlo based software, with that of several other methods for linkage and haplotype analyses, focusing on the simulated data from the New York City population. First, a whole-genome scan study based on the microsatellite markers was performed using GENEHUNTER. ...

journal_title：BMC genetics

authors： Lin S,Ding J,Dong C,Liu Z,Ma ZJ,Wan S,Xu Y

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. Transcription of SLa is enhanced or suppressed when fish are kept in dark or bright conditions, respectively, indicating SLa's important ro...

journal_title：BMC genetics

authors： Sasano Y,Yoshimura A,Fukamachi S

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been reported in the past few years. Most of the quantitative trait loci (QTLs) for GY under drought in rice r...

journal_title：BMC genetics

authors： Vikram P,Swamy BP,Dixit S,Ahmed HU,Teresa Sta Cruz M,Singh AK,Kumar A

更新日期：2011-10-18 00:00:00

abstract：:The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...

journal_title：BMC genetics

authors： Liu X,Jorgenson E,Witte JS

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...

journal_title：BMC genetics

authors： Zhang C,Ye L,Chen Y,Xiao J,Wu Y,Tao M,Xiao Y,Liu S

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

journal_title：BMC genetics

authors： Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

更新日期：2010-12-07 00:00:00