Abstract：
BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability. RESULTS:In a large sample of children from the Avon Longitudinal Study of Parents and Children, we confirmed an association between bitter compound tasting ability and TAS2R38 variation and found evidence of a genetic association with intermediate tasting ability. Antisocial behaviour, social class and depression showed no consistent relationship with the distribution of taste test scores. CONCLUSION:Factors which could influence a child's chosen taste score, extra to taste receptor variation, appeared not to show relationships with test score. Observed spread in the distribution of the taste test scores within hypothesised taster groups, is likely to be, or at least in part, due to physiological differentiation regulated by other genetic contributors. Results confirm relationships between genetic variation and bitter compound tasting ability in a large sample, and suggest that TAS2R38 variation may also be associated with intermediate tasting ability.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith Gdoi
10.1186/1471-2156-8-51subject
Has Abstractpub_date
2007-07-28 00:00:00pages
51issn
1471-2156pii
1471-2156-8-51journal_volume
8pub_type
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