The effects of the DNA Demethylating reagent, 5-azacytidine on SMCHD1 genomic localization.

abstract：BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...

journal_title：BMC genetics

authors： Druka A,Druka I,Centeno AG,Li H,Sun Z,Thomas WT,Bonar N,Steffenson BJ,Ullrich SE,Kleinhofs A,Wise RP,Close TJ,Potokina E,Luo Z,Wagner C,Schweizer GF,Marshall DF,Kearsey MJ,Williams RW,Waugh R

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Female lions generally do not disperse far beyond their natal range, while males can disperse distances of over 200 km. However, in bush-like ecosystems dispersal distances less than 25 km are reported. Here, we investigate dispersal in lions sampled from the northern and southern extremes of Kruger National...

journal_title：BMC genetics

authors： van Hooft P,Keet DF,Brebner DK,Bastos ADS

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo)...

journal_title：BMC genetics

authors： Cheong HS,Yoon DH,Park BL,Kim LH,Bae JS,Namgoong S,Lee HW,Han CS,Kim JO,Cheong IC,Shin HD

更新日期：2008-04-19 00:00:00

abstract：BACKGROUND:Genome-wide investigation of molecular mechanisms for high-altitude adaptation has attracted great attention in the last few years. In order to understand the contribution of gene expression level variations to high-altitude adaptation in Asiatic toads (Bufo gargarizans), we implemented a reciprocal transpla...

journal_title：BMC genetics

authors： Yang W,Qi Y,Lu B,Qiao L,Wu Y,Fu J

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Monogenic diabetes is a genetic disease often caused by mutations in genes involved in beta-cell function. Correct sub-categorization of the disease is a prerequisite for appropriate treatment and genetic counseling. Target-region capture sequencing is a combination of genomic region enrichment and next gene...

journal_title：BMC genetics

authors： Gao R,Liu Y,Gjesing AP,Hollensted M,Wan X,He S,Pedersen O,Yi X,Wang J,Hansen T

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

journal_title：BMC genetics

authors： Bagos PG

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

journal_title：BMC genetics

authors： Hussey DJ,Moore S,Nicola M,Dobrovic A

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:mRNA expression in a cell or subcellular organelle is precisely regulated for the purpose of gene function regulation. The 3' untranslated region (3'UTR) of mRNA is the binding target of microRNA and RNA binding proteins. Their interactions regulate mRNA level in specific subcellular regions and determine th...

journal_title：BMC genetics

authors： Li T,Kuang Y,Li B

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Sugar beet is an obligate outcrossing species. Varieties consist of mixtures of plants from various parental combinations. As the number of informative morphological characteristics is limited, this leads to some problems in variety registration research. RESULTS:We have developed 25 new microsatellite mark...

journal_title：BMC genetics

authors： Smulders MJ,Esselink GD,Everaert I,De Riek J,Vosman B

更新日期：2010-05-18 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage of this approach is that...

journal_title：BMC genetics

authors： Wason JM,Dudbridge F

更新日期：2010-09-09 00:00:00

abstract：:Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing data for polygenic models using family data. The imputation schemes take into account familial relationships a...

journal_title：BMC genetics

authors： Fridley B,Rabe K,de Andrade M

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present st...

journal_title：BMC genetics

authors： Yao F,Zhang X,Ye X,Li J,Long L,Yu C,Li J,Wang Y,Wu Y,Wang J,Jiang Q,Li W,Ma J,Wei Y,Zheng Y,Chen G

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:Body size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We per...

journal_title：BMC genetics

authors： An B,Xu L,Xia J,Wang X,Miao J,Chang T,Song M,Ni J,Xu L,Zhang L,Li J,Gao H

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study, we aimed to identify major QTLs for kernel length, as well as putative candidate genes that migh...

journal_title：BMC genetics

authors： Zhou H,Liu S,Liu Y,Liu Y,You J,Deng M,Ma J,Chen G,Wei Y,Liu C,Zheng Y

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Currently, a commonly used strategy for mapping complex quantitative traits is to use a genome-wide linkage analysis to narrow suspected genes to regions on a scale of centiMorgans (cM), followed by an association analysis to fine map the genetic variation in regions showing linkage. Two important questions ...

journal_title：BMC genetics

authors： Wang T,Elston RC

更新日期：2006-01-20 00:00:00

abstract：BACKGROUND:Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. RESULTS:Candidate genetic loci associated with habitual coffee consumption were searched within...

journal_title：BMC genetics

authors： Jia H,Nogawa S,Kawafune K,Hachiya T,Takahashi S,Igarashi M,Saito K,Kato H

更新日期：2019-07-26 00:00:00

abstract：:The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study this question, two types of covariate models were used in the simulated Genetic Analysis Workshop 14 dataset i...

journal_title：BMC genetics

authors： Bailey JN

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Overexploitation of wildlife populations results in direct consequences, such as extinction and local extirpation, as well as indirect effects including genetic diversity loss and changes in genetic structure. A clear understanding of the underlying genetic patterns of harvested species is necessary for sust...

journal_title：BMC genetics

authors： Dowell SA,de Buffrénil V,Kolokotronis SO,Hekkala ER

更新日期：2015-03-28 00:00:00

abstract：BACKGROUND:This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified using limma package in R software. ...

journal_title：BMC genetics

authors： He J,Gao Y,Wu G,Lei X,Zhang Y,Pan W,Yu H

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Marek's disease (MD) is a highly neoplastic disease primarily affecting chickens, and remains as a chronic infectious disease that threatens the poultry industry. Copy number variation (CNV) has been examined in many species and is recognized as a major source of genetic variation that directly contributes t...

journal_title：BMC genetics

authors： Bai H,He Y,Ding Y,Chu Q,Lian L,Heifetz EM,Yang N,Cheng HH,Zhang H,Chen J,Song J

更新日期：2020-07-16 00:00:00

abstract：:Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Genetic Analysis Workshop 14 (GAW14) in order to search for genes predisposing to alcohol dependence. Using factor...

journal_title：BMC genetics

authors： Yu Y,Meng Y,Ma Q,Farrell J,Farrer LA,Wilcox MA

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, from national newborn screening programs may provide a DNA source for entire populations. Combined ...

journal_title：BMC genetics

authors： Hollegaard MV,Grove J,Grauholm J,Kreiner-Møller E,Bønnelykke K,Nørgaard M,Benfield TL,Nørgaard-Pedersen B,Mortensen PB,Mors O,Sørensen HT,Harboe ZB,Børglum AD,Demontis D,Ørntoft TF,Bisgaard H,Hougaard DM

更新日期：2011-07-04 00:00:00

abstract：:Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure. We show how the additional information available in these longitudinal data can be utilized to examine linkag...

journal_title：BMC genetics

authors： Jacobs KB,Gray-McGuire C,Cartier KC,Elston RC

更新日期：2003-12-31 00:00:00

abstract：BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic ...

journal_title：BMC genetics

authors： Giovambattista G,Moe KK,Polat M,Borjigin L,Hein ST,Moe HH,Takeshima SN,Aida Y

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...

journal_title：BMC genetics

authors： Silva NM,Rio J,Currat M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confu...

journal_title：BMC genetics

authors： Wang T,Zeng ZB

更新日期：2009-09-04 00:00:00

abstract：:Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...

journal_title：BMC genetics

authors： Heidema AG,Boer JM,Nagelkerke N,Mariman EC,van der A DL,Feskens EJ

更新日期：2006-04-21 00:00:00

abstract：BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...

journal_title：BMC genetics

authors： Fernández AI,Muñoz M,Alves E,Folch JM,Noguera JL,Enciso MP,Rodríguez Mdel C,Silió L

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian t...

journal_title：BMC genetics

authors： Maciąg A,Villa F,Ferrario A,Spinelli CC,Carrizzo A,Malovini A,Torella A,Montenero C,Parisi A,Condorelli G,Vecchione C,Nigro V,Montenero AS,Puca AA

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease. Three in-bred strains of rats, WKY, SHR and SHRSP, are known to be sitosterolemi...

journal_title：BMC genetics

authors： Chen J,Batta A,Zheng S,Fitzgibbon WR,Ullian ME,Yu H,Tso P,Salen G,Patel SB

更新日期：2005-07-18 00:00:00