Abstract:
BACKGROUND:Overexploitation of wildlife populations results in direct consequences, such as extinction and local extirpation, as well as indirect effects including genetic diversity loss and changes in genetic structure. A clear understanding of the underlying genetic patterns of harvested species is necessary for sustainable management. The Nile monitor (Varanus niloticus) is a commercially valuable species in the international leather industry, with the highest levels of exploitation concentrated throughout Sahelian Africa. In this study, we examined the fine-scale genetic patterns of V. niloticus populations in the Sahel, with the expectation that the genetic structure would correspond to riverine drainage basins. The analyses were based on genotypes at 11 microsatellite loci for 318 individuals, spanning three separate watersheds throughout the Sahel. RESULTS:Our analyses identified four genetic clusters throughout the region, one of which (the westernmost population) exhibited very high levels of genetic differentiation (FST = 0.47). Contrary to our expectation, the largest genetic break occurred within a single watershed, the Niger basin, rather than between watersheds. However, other localities displayed evidence of reduced gene flow between watershed boundaries. Across methods, the westernmost population exhibited lower estimates of N e as well as lower levels of genetic diversity compared to the other inferred populations. While we did not detect evidence for recent population bottlenecks, our analyses indicated historic population declines around 1,000-1,800 years ago. CONCLUSION:We found that the underlying genetic structure of Varanus niloticus across Sahelian Africa reflects historic as well as present-day patterns of riverine drainages. The high degree of differentiation found for the westernmost population indicates the presence of a separate lineage, and should be taken into consideration when setting harvest limits. The historic population decline for two of the populations corresponds to a drastic expansion of an ancient human civilization in the region, suggesting that human exploitation of V. niloticus has a longer history than previously thought.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Dowell SA,de Buffrénil V,Kolokotronis SO,Hekkala ERdoi
10.1186/s12863-015-0188-xsubject
Has Abstractpub_date
2015-03-28 00:00:00pages
32issn
1471-2156pii
10.1186/s12863-015-0188-xjournal_volume
16pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = AA) (♀) × common carp (Cyprinus carpio L. 2n = 100, 2n = BB) (♂), provided a good platform to inv...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0295-8
更新日期:2015-12-03 00:00:00
abstract:BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-2-20
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Sugar beet is an obligate outcrossing species. Varieties consist of mixtures of plants from various parental combinations. As the number of informative morphological characteristics is limited, this leads to some problems in variety registration research. RESULTS:We have developed 25 new microsatellite mark...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-41
更新日期:2010-05-18 00:00:00
abstract:BACKGROUND:Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS:Published clinical tr...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-60
更新日期:2007-09-10 00:00:00
abstract:BACKGROUND:Population stratification can cause spurious associations in a genome-wide association study (GWAS), and occurs when differences in allele frequencies of single nucleotide polymorphisms (SNPs) are due to ancestral differences between cases and controls rather than the trait of interest. Principal components ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-108
更新日期:2010-12-09 00:00:00
abstract:BACKGROUND:Despite several thousands of years of close contacts, there are genetic differences between the neighbouring countries of Finland and Sweden. Within Finland, signs of an east-west duality have been observed, whereas the population structure within Sweden has been suggested to be more subtle. With a fine-scal...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-54
更新日期:2008-08-19 00:00:00
abstract:BACKGROUND:Association mapping studies offer great promise to identify polymorphisms associated with phenotypes and for understanding the genetic basis of quantitative trait variation. To date, almost all association mapping studies based on structured plant populations examined the main effects of genetic factors on t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-3
更新日期:2014-01-06 00:00:00
abstract:BACKGROUND:South African (SA) Black women have a high prevalence of preeclampsia and HIV, both conditions associated with increased inflammation. miR-146a is an inflammatory-associated miR and a common single nucleotide polymorphism (rs2910164) has been associated with several disease conditions. To date, this SNP has ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0469-z
更新日期:2017-01-19 00:00:00
abstract:BACKGROUND:The transcription factor 7-like 2 (TCF7L2) gene is the most significant genetic risk factor for type 2 diabetes (T2D). Association analyses were performed on participants (n = 751, aged between 30 and 64) in the ISOR population-based study in the city of Oran. Dietary intakes were estimated using a weekly fo...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0134-3
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Congenital heart defects (CHD) is the most common cause of death from a congenital structure abnormality in newborns and is often associated with fetal loss. There are many types of CHD. Human genetic studies have identified genes that are responsible for the inheritance of a particular type of CHD and for s...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-44
更新日期:2013-05-24 00:00:00
abstract:BACKGROUND:Feed efficiency is one of the major components determining costs of animal production. Residual feed intake (RFI) is defined as the difference between the observed and the expected feed intake given a certain production. Residual feed intake 1 (RFI1) was calculated based on regression of individual daily fee...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-27
更新日期:2014-02-17 00:00:00
abstract::A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly use...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S159
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Several lines of evidence including allozyme analysis, restriction digest patterns and sequencing of mtDNA as well as mini- and micro-satellite allele frequencies indicate that Atlantic salmon (Salmo salar) from North America and Europe are genetically distinct. These observations are supported by karyotype ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-105
更新日期:2010-11-23 00:00:00
abstract:BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-28
更新日期:2011-03-04 00:00:00
abstract:BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-73
更新日期:2008-11-18 00:00:00
abstract::Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S113
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under t...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0639-2
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0673-0
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00889-5
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Neutrophil cytosolic factor-1 (NCF1) is a component of NADPH oxidase. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. Here, we report a copy number variation (CNV) of the NCF1 pseudogenes ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-13
更新日期:2010-02-23 00:00:00
abstract::Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...
journal_title:BMC genetics
pub_type: 社论
doi:10.1186/1471-2156-7-23
更新日期:2006-04-21 00:00:00
abstract:BACKGROUND:Haematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especiall...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-11-56
更新日期:2010-06-28 00:00:00
abstract:BACKGROUND:Selection for grain yield under drought is an efficient criterion for improving the drought tolerance of rice. Recently, some drought-tolerant rice varieties have been developed using this selection criterion and successfully released for cultivation in drought-prone target environments. The process can be m...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-14-12
更新日期:2013-02-26 00:00:00
abstract:BACKGROUND:Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may in...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0575-6
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:Genetic maps based on single-nucleotide polymorphisms (SNP) are increasingly being used as an alternative to microsatellite maps. This study compares linkage results for both types of maps for a neurophysiology phenotype and for an alcohol dependence phenotype. Our analysis used two SNP maps on the Illumina ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S122
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Late embryogenesis abundant (LEA) proteins are large groups of hydrophilic proteins with major role in drought and other abiotic stresses tolerance in plants. In-depth study and characterization of LEA protein families have been carried out in other plants, but not in upland cotton. The main aim of this rese...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0596-1
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two major challenges arise in haplotype-based association analysis of family data. First, haplotypes may ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00902-x
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-51
更新日期:2007-07-28 00:00:00
abstract:BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-87
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0553-z
更新日期:2017-10-23 00:00:00