Abstract:
BACKGROUND:Compared to model-based approaches, nonparametric methods for quantitative trait loci mapping are more robust to deviations in distributional assumptions. In this study, we modify a nonparametric regression method and the "contrast function"- based regression method to analyze total cholesterol level in the younger cohort (the offspring generation) of the Genetic Analysis Workshop 13 simulated data set. RESULTS:We obtained significant evidence of linkage near four of the six non-sex-specific genes in at least 30% of the replicates. CONCLUSIONS:The proposed nonparametric method seems to be a powerful robust alternative to distribution-based methods.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Ghosh S,Bertelsen S,Reich Tdoi
10.1186/1471-2156-4-S1-S92keywords:
subject
Has Abstractpub_date
2003-12-31 00:00:00pages
S92issn
1471-2156pii
1471-2156-4-S1-S92journal_volume
4 Suppl 1pub_type
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