Abstract:
BACKGROUND:The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current tobacco use disorder, diagnosed according to DSM IV criteria (n = 185), and never-smokers, diagnosed according to CDC criteria (n = 175), were recruited and received 52 weeks of combined pharmacotherapy and cognitive therapy. Successful smoking cessation was defined as exhaled carbon monoxide < 6 ppm. SLC6A4 gene STin2 VNTR polymorphism was assessed using a Multiplex-PCR-based method. At baseline, participants were evaluated using the Fagerström Test for Nicotine Dependence (FTND) and the ASSIST scale. RESULTS:The STin2.12 allele (OR = 2.45; 95% CI = 1.44-4.15, p < 0.001) was associated with an increased risk for tobacco use disorder, while the STin2.10/10 genotype (OR = 0.42; 95% CI 0.25-0.71, p < 0.001) decreased risk. There were no significant associations between tobacco use disorder and the STin2.10 or STin2.9 alleles or the other genotypes (STin2.12/12, 12/10, 12/9, 10/9 or 9/9). There were no significant associations between the STin2 genotypes and alleles and successful smoking cessation, smoking characteristics and increased alcohol or sedative use risk. CONCLUSIONS:Our results suggest that the STin2.10/10 genotype and STin2.12 allele are associated with tobacco use disorder or nicotine dependence, but not with treatment response or severity of dependence. It is hypothesized that the ST2in.12 allele by modulating the metabolism of serotonin may participate in the pathophysiology of tobacco use disorder or nicotine dependence.
journal_name
BMC Genetjournal_title
BMC geneticsauthors
Pizzo de Castro MR,Maes M,Guembarovski RL,Ariza CB,Reiche EM,Vargas HO,Vargas MM,de Melo LG,Dodd S,Berk M,Watanabe MA,Nunes SOdoi
10.1186/1471-2156-15-78subject
Has Abstractpub_date
2014-06-27 00:00:00pages
78issn
1471-2156pii
1471-2156-15-78journal_volume
15pub_type
杂志文章相关文献
BMC GENETICS文献大全abstract:BACKGROUND:Grasslands in the Arctic tundra undergo irreversible degradation due to climatic changes and also over-exploitation and depletion of scarce resources. Comprehensive investigations of cytogenomic structures of valuable Arctic and sub-Arctic grassland species is essential for clarifying their genetic peculiari...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0792-2
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Sexual precocity is a common biological phenomenon in animal species. A large number of precocity individuals were identified in Chinese mitten crab Eriocheir sinensis, which caused huge economic loss annually. However, the underlying genetic basis of precocity in E. sinensis remains unclear to date. RESULT...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0716-1
更新日期:2019-01-25 00:00:00
abstract:BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-18
更新日期:2007-05-04 00:00:00
abstract::An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance components-based linkage analysis. On the examined simulated, error-free data...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S72
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0148-x
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:India is home to many ethnically and linguistically diverse populations. It is hypothesized that history of invasions by people from Persia and Central Asia, who are referred as Aryans in Hindu Holy Scriptures, had a defining role in shaping the Indian population canvas. A shift in spoken languages from Drav...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-86
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:The monocyte chemoattractant protein 1 (MCP-1) is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-34
更新日期:2011-04-19 00:00:00
abstract:BACKGROUND:Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0467-1
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:The use of pooled DNA on SNP microarrays (SNP-MaP) has been shown to be a cost effective and rapid manner to perform whole-genome association evaluations. While the accuracy of SNP-MaP was extensively evaluated on the early Affymetrix 10 k and 100 k platforms, there have not been as many similarly comprehens...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-10-82
更新日期:2009-12-14 00:00:00
abstract:BACKGROUND:The spotted-wing Drosophila (Drosophila suzukii) is a widespread invasive pest that causes severe economic damage to fruit crops. The early development of D. suzukii is similar to that of other Drosophilids, but the roles of individual genes must be confirmed experimentally. Cellularization genes coordinate ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00939-y
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:Brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS, OMIA 001595-9940 ) is a previously reported recessively inherited disorder in Australian Poll Merino/Merino sheep. Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00913-8
更新日期:2020-09-15 00:00:00
abstract::The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease itself. Some disease-associated phenotypes are rare, however, making it difficult to evaluate their effects due to small ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-6-S1-S104
更新日期:2005-12-30 00:00:00
abstract:BACKGROUND:Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously reported that most individuals with CFEOM1 and rare individuals with CFEOM3 harbor heterozygous mutatio...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-26
更新日期:2007-05-18 00:00:00
abstract:BACKGROUND:Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present st...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-019-0736-x
更新日期:2019-03-26 00:00:00
abstract::Participants in the family-based analysis group at Genetic Analysis Workshop 19 addressed diverse topics, all of which used the family data. Topics addressed included questions of study design and data quality control (QC), genotype imputation to augment available sequence data, and linkage and/or association analyses...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0318-5
更新日期:2016-02-03 00:00:00
abstract:BACKGROUND:Typically, the first phase of a genome wide association study (GWAS) includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide ad...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-94
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Growth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accurate prediction of breeding values of animals without own phenotypic information. This study investiga...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-014-0110-y
更新日期:2014-10-15 00:00:00
abstract:BACKGROUND:Two key questions in understanding the genetic control of behaviors are: what genes are involved and how these genes interact. To answer these questions at a systems level, we conducted high-content profiling of Drosophila larval locomotor behaviors for over 100 genotypes. RESULTS:We studied 69 genes whose ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-017-0513-7
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have crucial roles in various biological regulatory processes. However, the study of lncRNAs is limited in woody plants. Catalpa bungei is a valuable ornamental tree with a long cultivation history in China, and a deeper understanding of the floral transition mechanism in C. bu...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-018-0671-2
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Adaption to cold temperatures, especially those below freezing, is essential for animal survival in cold environments. Freezing is also used for many medical, scientific, and industrial purposes. Natural freezing survival in animals has been extensively studied. However, the underlying mechanisms remain uncl...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-015-0298-5
更新日期:2015-12-03 00:00:00
abstract:BACKGROUND:The disease gene of fragile X syndrome, FMR1 gene, encodes fragile X mental retardation protein (FMRP). The alternative splicing (AS) of FMR1 can affect the structure and function of FMRP. However, the biological functions of alternatively spliced isoforms remain elusive. In a previous study, we identified a...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-020-00870-2
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/s12863-016-0351-z
更新日期:2016-02-13 00:00:00
abstract:BACKGROUND:Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. RESULTS:Candidate genetic loci associated with habitual coffee consumption were searched within...
journal_title:BMC genetics
pub_type: 杂志文章,meta分析
doi:10.1186/s12863-019-0763-7
更新日期:2019-07-26 00:00:00
abstract:BACKGROUND:We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations. RESULTS:Sequence reads from light shot-gun sequencing efforts of different dog breeds were aligned to the dog genome reference sequence and gaps corresponding to indels were identified. One h...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-8
更新日期:2008-01-22 00:00:00
abstract:BACKGROUND:Human glycosylase IV is involved in GLUT2 transporter regulation in pancreatic beta cells. A KO of this gene along with a high fat diet in a mice model has been associated with the development of type 2 diabetes (T2D). The aims of this study were to measure and compare the MGAT4A mRNA levels in white blood c...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-8-73
更新日期:2007-10-22 00:00:00
abstract:BACKGROUND:Boar taint is an unpleasant condition of pork, mainly due to the accumulation of androstenone and skatole in male pigs at onset of puberty. This condition is the cause of considerable economic losses in the pig industry and the most common practice to control it is to castrate male piglets. Because of the ec...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-12-35
更新日期:2011-04-20 00:00:00
abstract:BACKGROUND:Land plants have evolved several measures to maintain their life against abiotic stresses. The accumulation of proline is the most generalized response of plants under drought, heat or salt stress conditions. It is known as an osmoprotectant which also acts as an instant source of energy during drought recov...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-13-61
更新日期:2012-07-20 00:00:00
abstract::The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from the longitudinal Framingham Heart Study Family Cohort to investigate the familial aggregation and ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-4-S1-S12
更新日期:2003-12-31 00:00:00
abstract:BACKGROUND:Discerning the traits evolving under neutral conditions from those traits evolving rapidly because of various selection pressures is a great challenge. We propose a new method, composite selection signals (CSS), which unifies the multiple pieces of selection evidence from the rank distribution of its diverse...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-15-34
更新日期:2014-03-17 00:00:00
abstract:BACKGROUND:Genetic maps characterizing the inheritance patterns of traits and markers have been developed for a wide range of species and used to study questions in biomedicine, agriculture, ecology and evolutionary biology. The status of rainbow trout genetic maps has progressed significantly over the last decade due ...
journal_title:BMC genetics
pub_type: 杂志文章
doi:10.1186/1471-2156-9-74
更新日期:2008-11-19 00:00:00