The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients.

abstract：BACKGROUND:Congenital heart defects (CHD) is the most common cause of death from a congenital structure abnormality in newborns and is often associated with fetal loss. There are many types of CHD. Human genetic studies have identified genes that are responsible for the inheritance of a particular type of CHD and for s...

journal_title：BMC genetics

authors： Flaquer A,Baumbach C,Piñero E,García Algas F,de la Fuente Sanchez MA,Rosell J,Toquero J,Alonso-Pulpon L,Garcia-Pavia P,Strauch K,Heine-Suñer D

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Yami and Ivatan islanders are Austronesian speakers from Orchid Island and the Batanes archipelago that are located between Taiwan and the Philippines. The paternal genealogies of the Yami tribe from 1962 monograph of Wei and Liu were compared with our dataset of non-recombining Y (NRY) chromosomes from the ...

journal_title：BMC genetics

authors： Loo JH,Trejaut JA,Yen JC,Chen ZS,Lee CL,Lin M

更新日期：2011-01-31 00:00:00

abstract：BACKGROUND:A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems le...

journal_title：BMC genetics

authors： Druka A,Druka I,Centeno AG,Li H,Sun Z,Thomas WT,Bonar N,Steffenson BJ,Ullrich SE,Kleinhofs A,Wise RP,Close TJ,Potokina E,Luo Z,Wagner C,Schweizer GF,Marshall DF,Kearsey MJ,Williams RW,Waugh R

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Non-invasive sampling has opened avenues for the genetic study of elusive species, which has contributed significantly to their conservation. Where field based identity of non-invasive sample is ambiguous (e.g. carnivore scats), it is essential to establish identity of the species through molecular approache...

journal_title：BMC genetics

authors： Maroju PA,Yadav S,Kolipakam V,Singh S,Qureshi Q,Jhala Y

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain...

journal_title：BMC genetics

authors： Labots M,Laarakker MC,Ohl F,van Lith HA

更新日期：2016-06-29 00:00:00

abstract：BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

journal_title：BMC genetics

authors： Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

更新日期：2007-07-28 00:00:00

abstract：BACKGROUND:Female lions generally do not disperse far beyond their natal range, while males can disperse distances of over 200 km. However, in bush-like ecosystems dispersal distances less than 25 km are reported. Here, we investigate dispersal in lions sampled from the northern and southern extremes of Kruger National...

journal_title：BMC genetics

authors： van Hooft P,Keet DF,Brebner DK,Bastos ADS

更新日期：2018-04-03 00:00:00

abstract：:Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applications, we first performed a preliminary genome scan study based on the microsatellite markers using the GENEHU...

journal_title：BMC genetics

authors： Papachristou C,Lin S

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for ...

journal_title：BMC genetics

authors： Jin T,Chen J,Zhu L,Zhao Y,Guo J,Huang Y

更新日期：2015-02-14 00:00:00

abstract：BACKGROUND:Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on su...

journal_title：BMC genetics

authors： Haase B,Doherr MG,Seuberlich T,Drögemüller C,Dolf G,Nicken P,Schiebel K,Ziegler U,Groschup MH,Zurbriggen A,Leeb T

更新日期：2007-04-16 00:00:00

abstract：BACKGROUND:This study aimed to explore the molecular mechanism of estrogen-mediated neuroprotection in the relief of cerebral ischemic injury. The gene expression profiles were downloaded from Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified using limma package in R software. ...

journal_title：BMC genetics

authors： He J,Gao Y,Wu G,Lei X,Zhang Y,Pan W,Yu H

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs). RESULTS:...

journal_title：BMC genetics

authors： Hothorn LA,Libiger O,Gerhard D

更新日期：2012-07-18 00:00:00

abstract：BACKGROUND:Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the genetic diversity and relationship within and between the four main Sudanese breeds of Nubian, Desert, T...

journal_title：BMC genetics

authors： Rahmatalla SA,Arends D,Reissmann M,Said Ahmed A,Wimmers K,Reyer H,Brockmann GA

更新日期：2017-10-23 00:00:00

abstract：:Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if they have either the disease or the DRT, or both. We propose instead to consider the joint distribution of the ...

journal_title：BMC genetics

authors： Ji F,Lee D,Mendell NR

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The search to identify disease-susceptible genes requires access to biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, from national newborn screening programs may provide a DNA source for entire populations. Combined ...

journal_title：BMC genetics

authors： Hollegaard MV,Grove J,Grauholm J,Kreiner-Møller E,Bønnelykke K,Nørgaard M,Benfield TL,Nørgaard-Pedersen B,Mortensen PB,Mors O,Sørensen HT,Harboe ZB,Børglum AD,Demontis D,Ørntoft TF,Bisgaard H,Hougaard DM

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basi...

journal_title：BMC genetics

authors： Goryca K,Kulecka M,Paziewska A,Dabrowska M,Grzelak M,Skrzypczak M,Ginalski K,Mroz A,Rutkowski A,Paczkowska K,Mikula M,Ostrowski J

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in ex...

journal_title：BMC genetics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Szmatoła T,Piórkowska K,Bugno-Poniewierska M

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare vascular disorder characterized by a capillary wedge pressure ≤ 15 mmHg and a mean pulmonary arterial pressure ≥ 25 mmHg at rest. PAH can be idiopathic, heritable or associated with other conditions. The aim of this study was to analyze the Endoglin (ENG) gene ...

journal_title：BMC genetics

authors： Pousada G,Baloira A,Fontán D,Núñez M,Valverde D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo)...

journal_title：BMC genetics

authors： Cheong HS,Yoon DH,Park BL,Kim LH,Bae JS,Namgoong S,Lee HW,Han CS,Kim JO,Cheong IC,Shin HD

更新日期：2008-04-19 00:00:00

abstract：BACKGROUND:Pest eradication using the Sterile Insect Technique (SIT) involves high-density releases of sterilized males that mate with wild females and ultimately suppress the population. Sterilized females are not required for SIT and their removal or separation from males prior to release remains challenging. In orde...

journal_title：BMC genetics

authors： Choo A,Fung E,Chen IY,Saint R,Crisp P,Baxter SW

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Koala (Koa) is a dominant mutation in mice causing bushy muzzle and pinna, and is associated with a chromosomal inversion on the distal half of chromosome 15. To identify the gene responsible for the Koa phenotypes, we investigated phenotypes of Koa homozygous mice and determined the breakpoints of the inver...

journal_title：BMC genetics

authors： Katayama K,Miyamoto S,Furuno A,Akiyama K,Takahashi S,Suzuki H,Tsuji T,Kunieda T

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:mRNA expression in a cell or subcellular organelle is precisely regulated for the purpose of gene function regulation. The 3' untranslated region (3'UTR) of mRNA is the binding target of microRNA and RNA binding proteins. Their interactions regulate mRNA level in specific subcellular regions and determine th...

journal_title：BMC genetics

authors： Li T,Kuang Y,Li B

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. RESULTS:Candidate genetic loci associated with habitual coffee consumption were searched within...

journal_title：BMC genetics

authors： Jia H,Nogawa S,Kawafune K,Hachiya T,Takahashi S,Igarashi M,Saito K,Kato H

更新日期：2019-07-26 00:00:00

abstract：BACKGROUND:Genomic selection exploits dense genome-wide marker data to predict breeding values. In this study we used a large sugar beet population of 924 lines representing different germplasm types present in breeding populations: unselected segregating families and diverse lines from more advanced stages of selectio...

journal_title：BMC genetics

authors： Würschum T,Reif JC,Kraft T,Janssen G,Zhao Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:The SnRKs (sucrose non-fermenting 1 related protein kinase) are a gene family coding for Ser/Thr protein kinases and play important roles in linking the tolerance and metabolic responses of plants to abiotic stresses. To date, no genome-wide characterization of the sucrose non-ferment 1 related protein kinas...

journal_title：BMC genetics

authors： Bai J,Mao J,Yang H,Khan A,Fan A,Liu S,Zhang J,Wang D,Gao H,Zhang J

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of...

journal_title：BMC genetics

authors： Thutkawkorapin J,Picelli S,Kontham V,Liu T,Nilsson D,Lindblom A

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:The Glued gene of Drosophila melanogaster encodes the homologue of the vertebrate p150Glued subunit of dynactin. The Glued1 mutation compromises the dynein-dynactin retrograde motor complex and causes disruptions to the adult eye and the CNS, including sensory neurons and the formation of the giant fiber sys...

journal_title：BMC genetics

authors： Ma L,Johns LA,Allen MJ

更新日期：2009-11-30 00:00:00

abstract：:Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Genetic Analysis Workshop 14 (GAW14) in order to search for genes predisposing to alcohol dependence. Using factor...

journal_title：BMC genetics

authors： Yu Y,Meng Y,Ma Q,Farrell J,Farrer LA,Wilcox MA

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:The monocyte chemoattractant protein 1 (MCP-1) is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance...

journal_title：BMC genetics

authors： Intemann CD,Thye T,Förster B,Owusu-Dabo E,Gyapong J,Horstmann RD,Meyer CG

更新日期：2011-04-19 00:00:00

abstract：BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

journal_title：BMC genetics

authors： Hussey DJ,Moore S,Nicola M,Dobrovic A

更新日期：2001-01-01 00:00:00