LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

abstract：:mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected but important bioenergetic effect of mTOR inhibition in neurons. mTOR inhibition by rapamycin significantly preserves neuronal ATP leve...

journal_title：eLife

authors： Zheng X,Boyer L,Jin M,Kim Y,Fan W,Bardy C,Berggren T,Evans RM,Gage FH,Hunter T

更新日期：2016-03-23 00:00:00

abstract：:Transient receptor potential (TRP) ion channels in peripheral sensory neurons are functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of protein kinase mediated phosphorylation following activation of various G protein coupled receptors. We now show that the activity of TRPM...

journal_title：eLife

authors： Quallo T,Alkhatib O,Gentry C,Andersson DA,Bevan S

更新日期：2017-08-15 00:00:00

abstract：:Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some macrophages persist in the absence of CSF1R. Here, we analyzed mpeg1:GFP-expressing macrophages in csf1r-deficient zebrafish and report that embryonic macrophages emerg...

journal_title：eLife

authors： Kuil LE,Oosterhof N,Ferrero G,Mikulášová T,Hason M,Dekker J,Rovira M,van der Linde HC,van Strien PM,de Pater E,Schaaf G,Bindels EM,Wittamer V,van Ham TJ

更新日期：2020-05-05 00:00:00

abstract：:The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combin...

journal_title：eLife

authors： Kuwahara A,Lewis AE,Coombes C,Leung FS,Percharde M,Bush JO

更新日期：2020-06-09 00:00:00

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growt...

journal_title：eLife

authors： Tenente IM,Hayes MN,Ignatius MS,McCarthy K,Yohe M,Sindiri S,Gryder B,Oliveira ML,Ramakrishnan A,Tang Q,Chen EY,Petur Nielsen G,Khan J,Langenau DM

更新日期：2017-01-12 00:00:00

abstract：:Rising and more variable global temperatures pose a challenge for biodiversity, with reproduction and fertility being especially sensitive to heat. Here, we assessed the potential for thermal adaptation in sperm and egg function using Tribolium flour beetles, a warm-temperate-tropical insect model. Following temperatu...

journal_title：eLife

authors： Vasudeva R,Sutter A,Sales K,Dickinson ME,Lumley AJ,Gage MJ

更新日期：2019-10-01 00:00:00

abstract：:Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, Caenorhabditis tropicalis is the least genetically div...

journal_title：eLife

authors： Noble LM,Yuen J,Stevens L,Moya N,Persaud R,Moscatelli M,Jackson JL,Zhang G,Chitrakar R,Baugh LR,Braendle C,Andersen EC,Seidel HS,Rockman MV

更新日期：2021-01-11 00:00:00

abstract：:The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of ...

journal_title：eLife

authors： Paquola C,Benkarim O,DeKraker J,Larivière S,Frässle S,Royer J,Tavakol S,Valk S,Bernasconi A,Bernasconi N,Khan A,Evans AC,Razi A,Smallwood J,Bernhardt BC

更新日期：2020-11-04 00:00:00

abstract：:Although seasonality is widespread and can cause fluctuations in the intensity and direction of natural selection, we have little information about the consequences of seasonal fitness trade-offs for population dynamics. Here we exposed populations of Drosophila melanogaster to repeated seasonal changes in resources a...

journal_title：eLife

authors： Betini GS,McAdam AG,Griswold CK,Norris DR

更新日期：2017-02-06 00:00:00

abstract：:How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior-directed cortical flows and a single posterior PAR-2 domain. We unco...

journal_title：eLife

authors： Klinkert K,Levernier N,Gross P,Gentili C,von Tobel L,Pierron M,Busso C,Herrman S,Grill SW,Kruse K,Gönczy P

更新日期：2019-02-26 00:00:00

abstract：:Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal n...

journal_title：eLife

authors： Yamashita T,Petersen CCh

更新日期：2016-06-21 00:00:00

abstract：:The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells. It has remained controversial, however, whether mammalian and yeast IRE1 use a common mechanism for ER stress sensing. Here, we...

journal_title：eLife

authors： Karagöz GE,Acosta-Alvear D,Nguyen HT,Lee CP,Chu F,Walter P

更新日期：2017-10-03 00:00:00

abstract：:The speed at which a cell fate decision in nematode worms evolves is due to the number of genes that control the decision, rather than to a high mutation rate. ...

journal_title：eLife

authors： Yang B,Rifkin SA

更新日期：2020-10-14 00:00:00

abstract：:Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB o...

journal_title：eLife

authors： Manzano Nieves G,Bravo M,Baskoylu S,Bath KG

更新日期：2020-07-21 00:00:00

abstract：:Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understoo...

journal_title：eLife

authors： Dominguez D,Tsai YH,Weatheritt R,Wang Y,Blencowe BJ,Wang Z

更新日期：2016-03-25 00:00:00

abstract：:Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relating gamma oscillations, synaptic strength and circuit computations ar...

journal_title：eLife

authors： Solanka L,van Rossum MC,Nolan MF

更新日期：2015-07-06 00:00:00

abstract：:The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus. ...

journal_title：eLife

authors： Mathis D

更新日期：2013-11-05 00:00:00

abstract：:Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...

journal_title：eLife

authors： Gressel S,Schwalb B,Decker TM,Qin W,Leonhardt H,Eick D,Cramer P

更新日期：2017-10-10 00:00:00

abstract：:Accurate protein localization is crucial to generate and maintain organization in all cells. Achieving accuracy is challenging, as the molecular signals that dictate a protein's cellular destination are often promiscuous. A salient example is the targeting of an essential class of tail-anchored (TA) proteins, whose so...

journal_title：eLife

authors： Rao M,Okreglak V,Chio US,Cho H,Walter P,Shan SO

更新日期：2016-12-07 00:00:00

abstract：:The internal brain dynamics that link sensation and action are arguably better studied during natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking technique that monitors whole brain neural activity in freely swimming larval zebrafish (Danio rerio). We demonstrated the capability of our ...

journal_title：eLife

authors： Cong L,Wang Z,Chai Y,Hang W,Shang C,Yang W,Bai L,Du J,Wang K,Wen Q

更新日期：2017-09-20 00:00:00

abstract：:The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the α subunit of AP2 in the nematode Caenorhabditis elegans. α-adaptin mutants are viable and the remaining μ2/β hemicomplex retains some function. Conversely, in μ2 mutants, the alpha/sigma2 hemicomplex is loca...

journal_title：eLife

authors： Gu M,Liu Q,Watanabe S,Sun L,Hollopeter G,Grant BD,Jorgensen EM

更新日期：2013-03-05 00:00:00

abstract：:Unresolved ER stress followed by cell death is recognized as the main cause of a multitude of pathologies including neonatal diabetes. A systematic analysis of the mechanisms of β-cell loss and dysfunction in Akita mice, in which a mutation in the proinsulin gene causes a severe form of permanent neonatal diabetes, sh...

journal_title：eLife

authors： Riahi Y,Israeli T,Yeroslaviz R,Chimenez S,Avrahami D,Stolovich-Rain M,Alter I,Sebag M,Polin N,Bernal-Mizrachi E,Dor Y,Cerasi E,Leibowitz G

更新日期：2018-11-09 00:00:00

abstract：:When a female fly mates it produces a hormone that increases the size of its midgut and enhances fat metabolism in order to provide the energy needed for reproduction. ...

journal_title：eLife

authors： Flatt T

更新日期：2015-07-28 00:00:00

abstract：:Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their favor. It remains unclear how many species harbor them and how diverse their mechanisms are. Here, we discover two spore killers from a natural isolate of the fission yeast Schizosaccharomyces pombe. Both killers belong to ...

journal_title：eLife

authors： Hu W,Jiang ZD,Suo F,Zheng JX,He WZ,Du LL

更新日期：2017-06-20 00:00:00

abstract：:Claims that magnetic fields can be used to manipulate biological systems contradict some basic laws of physics. ...

journal_title：eLife

authors： Anikeeva P,Jasanoff A

更新日期：2016-09-08 00:00:00

abstract：:Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent...

journal_title：eLife

authors： Lee SH,Jin C,Cai E,Ge P,Ishitsuka Y,Teng KW,de Thomaz AA,Nall D,Baday M,Jeyifous O,Demonte D,Dundas CM,Park S,Delgado JY,Green WN,Selvin PR

更新日期：2017-07-27 00:00:00

abstract：:Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role...

journal_title：eLife

authors： Tsingos E,Höckendorf B,Sütterlin T,Kirchmaier S,Grabe N,Centanin L,Wittbrodt J

更新日期：2019-03-26 00:00:00

abstract：:Lamina-associated polypeptide 1 (LAP1) resides at the nuclear envelope and interacts with Torsins, poorly understood endoplasmic reticulum (ER)-localized AAA+ ATPases, through a conserved, perinuclear domain. We determined the crystal structure of the perinuclear domain of human LAP1. LAP1 possesses an atypical AAA+ f...

journal_title：eLife

authors： Sosa BA,Demircioglu FE,Chen JZ,Ingram J,Ploegh HL,Schwartz TU

更新日期：2014-08-22 00:00:00

abstract：:Evolutionary changes in transcription networks are an important source of diversity across species, yet the quantitative consequences of network evolution have rarely been studied. Here we consider the transcriptional 'rewiring' of the three GAL genes that encode the enzymes needed for cells to convert galactose to gl...

journal_title：eLife

authors： Dalal CK,Zuleta IA,Mitchell KF,Andes DR,El-Samad H,Johnson AD

更新日期：2016-09-10 00:00:00