Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.

abstract：:We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...

journal_title：eLife

authors： Díaz-Alonso J,Morishita W,Incontro S,Simms J,Holtzman J,Gill M,Mucke L,Malenka RC,Nicoll RA

更新日期：2020-08-24 00:00:00

abstract：:Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but progressively lose this ability. This correlates with reduced damage-responsive expression of multiple genes, including the WNT genes wingles...

journal_title：eLife

authors： Harris RE,Setiawan L,Saul J,Hariharan IK

更新日期：2016-02-03 00:00:00

abstract：:Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identified from Congenital...

journal_title：eLife

authors： Zhu JY,Fu Y,Nettleton M,Richman A,Han Z

更新日期：2017-01-20 00:00:00

abstract：:Two-component systems (TCS) are protein machineries that enable cells to respond to input signals. Histidine kinases (HK) are the sensory component, transferring information toward downstream response regulators (RR). HKs transfer phosphoryl groups to their specific RRs, but also dephosphorylate them, overall ensuring...

journal_title：eLife

authors： Trajtenberg F,Imelio JA,Machado MR,Larrieux N,Marti MA,Obal G,Mechaly AE,Buschiazzo A

更新日期：2016-12-12 00:00:00

abstract：:Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and many of these control activities depend upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that se...

journal_title：eLife

authors： Wamp S,Rutter ZJ,Rismondo J,Jennings CE,Möller L,Lewis RJ,Halbedel S

更新日期：2020-05-29 00:00:00

abstract：:Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...

journal_title：eLife

authors： Rodrigo Albors A,Tazaki A,Rost F,Nowoshilow S,Chara O,Tanaka EM

更新日期：2015-11-14 00:00:00

abstract：:Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find t...

journal_title：eLife

authors： Bianco C,Mohr I

更新日期：2019-12-16 00:00:00

abstract：:The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...

journal_title：eLife

authors： Panayi MC,Killcross S

更新日期：2018-07-25 00:00:00

abstract：:Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of the method in mammalian cells. Our approach uses short homology of 24-...

journal_title：eLife

authors： Wierson WA,Welker JM,Almeida MP,Mann CM,Webster DA,Torrie ME,Weiss TJ,Kambakam S,Vollbrecht MK,Lan M,McKeighan KC,Levey J,Ming Z,Wehmeier A,Mikelson CS,Haltom JA,Kwan KM,Chien CB,Balciunas D,Ekker SC,Clark KJ,We

更新日期：2020-05-15 00:00:00

abstract：:Rhythmic actions benefit from synchronization with external events. Auditory-paced finger tapping studies indicate the two cerebral hemispheres preferentially control different rhythms. It is unclear whether left-lateralized processing of faster rhythms and right-lateralized processing of slower rhythms bases upon hem...

journal_title：eLife

authors： Pflug A,Gompf F,Muthuraman M,Groppa S,Kell CA

更新日期：2019-11-07 00:00:00

abstract：:Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions within frontal cortex are poorly understood. To examine the dynamics underlying cognitive contro...

journal_title：eLife

authors： Tang H,Yu HY,Chou CC,Crone NE,Madsen JR,Anderson WS,Kreiman G

更新日期：2016-02-18 00:00:00

abstract：:Intergroup conflict contributes to human discrimination and violence, but persists because individuals make costly contributions to their group's fighting capacity. Yet, how group members effectively coordinate their contributions during intergroup conflict remains poorly understood. Here, we examine the role of oxyto...

journal_title：eLife

authors： Zhang H,Gross J,De Dreu C,Ma Y

更新日期：2019-01-25 00:00:00

abstract：:WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain protein...

journal_title：eLife

authors： Lin Z,Yang Z,Xie R,Ji Z,Guan K,Zhang M

更新日期：2019-09-05 00:00:00

abstract：:We are writing to comment on the recent study by Olesen et al., 2018 on antibiotic use and antibiotic resistance. ...

journal_title：eLife

authors： Pouwels KB,Butler CC,Robotham JV

更新日期：2019-05-03 00:00:00

abstract：:Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the crusta...

journal_title：eLife

authors： Zhang Y,Bucher D,Nadim F

更新日期：2017-07-10 00:00:00

abstract：:Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, us...

journal_title：eLife

authors： Hopp CS,Chiou K,Ragheb DR,Salman AM,Khan SM,Liu AJ,Sinnis P

更新日期：2015-08-13 00:00:00

abstract：:The representation of position in the mammalian brain is distributed across multiple neural populations. Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments. In contrast, the activity patterns of hippo...

journal_title：eLife

authors： Agmon H,Burak Y

更新日期：2020-08-11 00:00:00

abstract：:The sense of ownership of one's body is important for survival, e.g., in defending the body against a threat. However, in addition to affecting behavior, it also affects perception of the world. In the case of visuospatial perception, it has been shown that the sense of ownership causes external space to be perceptual...

journal_title：eLife

authors： van der Hoort B,Reingardt M,Ehrsson HH

更新日期：2017-08-17 00:00:00

abstract：:Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain indu...

journal_title：eLife

authors： Arima Y,Kamimura D,Atsumi T,Harada M,Kawamoto T,Nishikawa N,Stofkova A,Ohki T,Higuchi K,Morimoto Y,Wieghofer P,Okada Y,Mori Y,Sakoda S,Saika S,Yoshioka Y,Komuro I,Yamashita T,Hirano T,Prinz M,Murakami M

更新日期：2015-08-11 00:00:00

abstract：:Understanding the relationships between different properties of data, such as whether a genome or connectome has information about disease status, is increasingly important. While existing approaches can test whether two properties are related, they may require unfeasibly large sample sizes and often are not interpret...

journal_title：eLife

authors： Vogelstein JT,Bridgeford EW,Wang Q,Priebe CE,Maggioni M,Shen C

更新日期：2019-01-15 00:00:00

abstract：:Faithful chromosome segregation in all eukaryotes relies on centromeres, the chromosomal sites that recruit kinetochore proteins and mediate spindle attachment during cell division. The centromeric histone H3 variant, CenH3, is the defining chromatin component of centromeres in most eukaryotes, including animals, fung...

journal_title：eLife

authors： Drinnenberg IA,deYoung D,Henikoff S,Malik HS

更新日期：2014-09-23 00:00:00

abstract：:Some cortical neurons receive highly selective thalamocortical (TC) input, but others do not. Here, we examine connectivity of single thalamic neurons (lateral geniculate nucleus, LGN) onto putative fast-spike inhibitory interneurons in layer 4 of rabbit visual cortex. We show that three 'rules' regulate this connecti...

journal_title：eLife

authors： Bereshpolova Y,Hei X,Alonso JM,Swadlow HA

更新日期：2020-12-08 00:00:00

abstract：:Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in...

journal_title：eLife

authors： Auxerre-Plantié E,Nakamori M,Renaud Y,Huguet A,Choquet C,Dondi C,Miquerol L,Takahashi MP,Gourdon G,Junion G,Jagla T,Zmojdzian M,Jagla K

更新日期：2019-12-12 00:00:00

abstract：:Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (...

journal_title：eLife

authors： Seo AY,Lau PW,Feliciano D,Sengupta P,Gros MAL,Cinquin B,Larabell CA,Lippincott-Schwartz J

更新日期：2017-04-10 00:00:00

abstract：:The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test the hypothesis that inter-individual microbiota variation can arise solely from differences in the order and timing by which the gut is colonized early in life. Experiments in which mice were inoculated in sequence eith...

journal_title：eLife

authors： Martínez I,Maldonado-Gomez MX,Gomes-Neto JC,Kittana H,Ding H,Schmaltz R,Joglekar P,Cardona RJ,Marsteller NL,Kembel SW,Benson AK,Peterson DA,Ramer-Tait AE,Walter J

更新日期：2018-09-18 00:00:00

abstract：:Eukaryotic kinetochores connect spindlemicrotubules to chromosomal centromeres. A group of proteins called the Ctf19 complex (Ctf19c) in yeast and the constitutive centromere associated network (CCAN) in other organisms creates the foundation of a kinetochore. The Ctf19c/CCAN influences the timing of kinetochore assem...

journal_title：eLife

authors： Hinshaw SM,Harrison SC

更新日期：2019-02-14 00:00:00

abstract：:Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response t...

journal_title：eLife

authors： Atashpaz S,Samadi Shams S,Gonzalez JM,Sebestyén E,Arghavanifard N,Gnocchi A,Albers E,Minardi S,Faga G,Soffientini P,Allievi E,Cancila V,Bachi A,Fernández-Capetillo Ó,Tripodo C,Ferrari F,López-Contreras AJ,Costanzo V

更新日期：2020-03-12 00:00:00

abstract：:Genetic techniques have shed new light on the organization of the neurons in the ventral nervous system of the fruit fly. ...

journal_title：eLife

authors： Lovick JK,Omoto JJ,Hartenstein V

更新日期：2015-08-28 00:00:00

abstract：:Cells respond to protein misfolding and aggregation in the cytosol by adjusting gene transcription and a number of post-transcriptional processes. In parallel to functional reactions, cellular structure changes as well; however, the mechanisms underlying the early adaptation of cellular compartments to cytosolic prote...

journal_title：eLife

authors： Kopp Y,Lang WH,Schuster TB,Martínez-Limón A,Hofbauer HF,Ernst R,Calloni G,Vabulas RM

更新日期：2017-11-01 00:00:00

abstract：:Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative gradients promote stops and turns. This algorithm represents a foundation for the control of sensory...

journal_title：eLife

authors： Tastekin I,Khandelwal A,Tadres D,Fessner ND,Truman JW,Zlatic M,Cardona A,Louis M

更新日期：2018-11-22 00:00:00