Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability.

abstract：:Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures; this seizure protection is mediated by ATP-sensitive potassium (KAT...

journal_title：eLife

authors： Martínez-François JR,Fernández-Agüera MC,Nathwani N,Lahmann C,Burnham VL,Danial NN,Yellen G

更新日期：2018-01-25 00:00:00

abstract：:In many daily tasks, we make multiple decisions before reaching a goal. In order to learn such sequences of decisions, a mechanism to link earlier actions to later reward is necessary. Reinforcement learning (RL) theory suggests two classes of algorithms solving this credit assignment problem: In classic temporal-diff...

journal_title：eLife

authors： Lehmann MP,Xu HA,Liakoni V,Herzog MH,Gerstner W,Preuschoff K

更新日期：2019-11-11 00:00:00

abstract：:Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach cumbersom...

journal_title：eLife

authors： Hamodi AS,Martinez Sabino A,Fitzgerald ND,Moschou D,Crair MC

更新日期：2020-05-18 00:00:00

abstract：:A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarde...

journal_title：eLife

authors： Jagannathan M,Cummings R,Yamashita YM

更新日期：2018-03-26 00:00:00

abstract：:Although several sleep-regulating neuronal populations have been identified, little is known about how they interact with each other to control sleep/wake states. We previously identified neuropeptide VF (NPVF) and the hypothalamic neurons that produce it as a sleep-promoting system (Lee et al., 2017). Here we show us...

journal_title：eLife

authors： Lee DA,Oikonomou G,Cammidge T,Andreev A,Hong Y,Hurley H,Prober DA

更新日期：2020-12-18 00:00:00

abstract：:Temporal patterning of neural progenitors leads to the sequential production of diverse neurons. To understand how extrinsic cues influence intrinsic temporal programs, we studied Drosophila mushroom body progenitors (neuroblasts) that sequentially produce only three neuronal types: γ, then α'β', followed by αβ. Oppos...

journal_title：eLife

authors： Rossi AM,Desplan C

更新日期：2020-07-06 00:00:00

abstract：:Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the CC17 GBS hypervirulent clone. We studied the impact of estradiol (E2) and progesterone (P4), which impregnate the fetus during pregnancy, ...

journal_title：eLife

authors： Hays C,Touak G,Bouaboud A,Fouet A,Guignot J,Poyart C,Tazi A

更新日期：2019-11-11 00:00:00

abstract：:Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown how native TA proteins on mitochondria and peroxisomes evade Msp1 surv...

journal_title：eLife

authors： Weir NR,Kamber RA,Martenson JS,Denic V

更新日期：2017-09-14 00:00:00

abstract：:Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpr...

journal_title：eLife

authors： Delventhal R,Carlson JR

更新日期：2016-02-15 00:00:00

abstract：:The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and highly conserved, its function remains...

journal_title：eLife

authors： Vierra NC,Kirmiz M,van der List D,Santana LF,Trimmer JS

更新日期：2019-10-30 00:00:00

abstract：:Cell-cell communication in multicellular organisms depends on the dynamic and reversible phosphorylation of protein tyrosine residues. The receptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment and are well placed to influence cell signaling. However, the direct events do...

journal_title：eLife

authors： Fearnley GW,Young KA,Edgar JR,Antrobus R,Hay IM,Liang WC,Martinez-Martin N,Lin W,Deane JE,Sharpe HJ

更新日期：2019-03-29 00:00:00

abstract：:D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally expressing the isoforms in dopamine neurons of D2 receptor knockout mice, th...

journal_title：eLife

authors： Gantz SC,Robinson BG,Buck DC,Bunzow JR,Neve RL,Williams JT,Neve KA

更新日期：2015-08-26 00:00:00

abstract：:Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profiling of all cell types, a complementary method to isolate and sequence ...

journal_title：eLife

authors： Amamoto R,Garcia MD,West ER,Choi J,Lapan SW,Lane EA,Perrimon N,Cepko CL

更新日期：2019-12-09 00:00:00

abstract：:In bacteria, multicellular behaviors are regulated by cell-cell signaling through the exchange of both diffusible and contact-dependent signals. In a multicellular context, Myxococcus cells can share outer membrane (OM) materials by an unknown mechanism involving the traAB genes and gliding motility. Using live imagin...

journal_title：eLife

authors： Ducret A,Fleuchot B,Bergam P,Mignot T

更新日期：2013-07-23 00:00:00

abstract：:The phylogenetic placement of the morphologically simple placozoans is crucial to understanding the evolution of complex animal traits. Here, we examine the influence of adding new genomes from placozoans to a large dataset designed to study the deepest splits in the animal phylogeny. Using site-heterogeneous substitu...

journal_title：eLife

authors： Laumer CE,Gruber-Vodicka H,Hadfield MG,Pearse VB,Riesgo A,Marioni JC,Giribet G

更新日期：2018-10-30 00:00:00

abstract：:Certain neuron types fire spontaneously at high rates, an ability that is crucial for their function in brain circuits. The spontaneously active GABAergic neurons of the substantia nigra pars reticulata (SNr), a major output of the basal ganglia, provide tonic inhibition of downstream brain areas. A depolarizing 'leak...

journal_title：eLife

authors： Lutas A,Lahmann C,Soumillon M,Yellen G

更新日期：2016-05-13 00:00:00

abstract：:Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic receptor (Adrb3) agonists. These two beiging triggers have been used int...

journal_title：eLife

authors： Jiang Y,Berry DC,Graff JM

更新日期：2017-10-11 00:00:00

abstract：:In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy to target c-Myc" (Delmore et al., 2011). Here we report the resu...

journal_title：eLife

authors： Aird F,Kandela I,Mantis C,Reproducibility Project: Cancer Biology.

更新日期：2017-01-19 00:00:00

abstract：:T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain to destabilize mRNA ...

journal_title：eLife

authors： Ramiscal RR,Parish IA,Lee-Young RS,Babon JJ,Blagih J,Pratama A,Martin J,Hawley N,Cappello JY,Nieto PF,Ellyard JI,Kershaw NJ,Sweet RA,Goodnow CC,Jones RG,Febbraio MA,Vinuesa CG,Athanasopoulos V

更新日期：2015-10-23 00:00:00

abstract：:Baboons, members of the genus Papio, comprise six closely related species distributed throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological flexibility and a wider range of social systems than many other primates. This article summarizes our current knowledge of the natural history of...

journal_title：eLife

authors： Fischer J,Higham JP,Alberts SC,Barrett L,Beehner JC,Bergman TJ,Carter AJ,Collins A,Elton S,Fagot J,Ferreira da Silva MJ,Hammerschmidt K,Henzi P,Jolly CJ,Knauf S,Kopp GH,Rogers J,Roos C,Ross C,Seyfarth RM,Silk J,

更新日期：2019-11-12 00:00:00

abstract：:The representation of position in the mammalian brain is distributed across multiple neural populations. Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments. In contrast, the activity patterns of hippo...

journal_title：eLife

authors： Agmon H,Burak Y

更新日期：2020-08-11 00:00:00

abstract：:Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechan...

journal_title：eLife

authors： Hoyos M,Huber M,Förstner KU,Papenfort K

更新日期：2020-08-03 00:00:00

abstract：:Humans and other animals base important decisions on estimates of number, and intraparietal cortex is thought to provide a crucial substrate of this ability. However, it remains debated whether an independent neuronal processing mechanism underlies this 'number sense', or whether number is instead judged indirectly on...

journal_title：eLife

authors： Castaldi E,Piazza M,Dehaene S,Vignaud A,Eger E

更新日期：2019-07-24 00:00:00

abstract：:Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the S...

journal_title：eLife

authors： Vogan AA,Ament-Velásquez SL,Granger-Farbos A,Svedberg J,Bastiaans E,Debets AJ,Coustou V,Yvanne H,Clavé C,Saupe SJ,Johannesson H

更新日期：2019-07-26 00:00:00

abstract：:The fitness effects of synonymous mutations, nucleotide changes that do not alter the encoded amino acid, have often been assumed to be neutral, but a growing body of evidence suggests otherwise. We used site-directed mutagenesis coupled with direct measures of competitive fitness to estimate the distribution of fitne...

journal_title：eLife

authors： Lebeuf-Taylor E,McCloskey N,Bailey SF,Hinz A,Kassen R

更新日期：2019-07-19 00:00:00

abstract：:Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex (ORC) large subunit, is inherited into newly born cells after it binds to condensing chromosomes during the precedi...

journal_title：eLife

authors： Hossain M,Stillman B

更新日期：2016-07-26 00:00:00

abstract：:Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. Here we present the 1.8 Å resolution crystal structure of the Chlamydomonas IFT-B protein IFT80, which reveals the architecture of two N-terminal β-propelle...

journal_title：eLife

authors： Taschner M,Lorentzen A,Mourão A,Collins T,Freke GM,Moulding D,Basquin J,Jenkins D,Lorentzen E

更新日期：2018-04-16 00:00:00

abstract：:Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here high-resolution quantitative imaging, bioenergetics measurements and mitochondrial membrane potential- and redox-sensitive dyes are used to define RSV's impact...

journal_title：eLife

authors： Hu M,Schulze KE,Ghildyal R,Henstridge DC,Kolanowski JL,New EJ,Hong Y,Hsu AC,Hansbro PM,Wark PA,Bogoyevitch MA,Jans DA

更新日期：2019-06-27 00:00:00

abstract：:Increasing evidence highlights the important roles of microRNAs in mediating p53's tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein i...

journal_title：eLife

authors： Cao B,Wang K,Liao JM,Zhou X,Liao P,Zeng SX,He M,Chen L,He Y,Li W,Lu H

更新日期：2016-07-07 00:00:00

abstract：:The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amides, that block ATF6...

journal_title：eLife

authors： Gallagher CM,Garri C,Cain EL,Ang KK,Wilson CG,Chen S,Hearn BR,Jaishankar P,Aranda-Diaz A,Arkin MR,Renslo AR,Walter P

更新日期：2016-07-20 00:00:00