Abstract：
:Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activation and costimulation of the immune cells. We demonstrate that m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracellular protein sorting and packaging. As a consequence of the perturbed AP-1 sorting, m154 promotes lysosomal degradation of several proteins involved in T cell costimulation, thus impairing virus-specific CD8+ T cell response and virus control in vivo. Additionally, we show that HCMV infection similarly interferes with the AP-1 complex. Altogether, we identify the robust mechanism employed by single viral immunomodulatory protein targeting a broad spectrum of cell surface molecules involved in the antiviral immune response.
journal_name
Elifejournal_title
eLifeauthors
Strazic Geljic I,Kucan Brlic P,Angulo G,Brizic I,Lisnic B,Jenus T,Juranic Lisnic V,Pietri GP,Engel P,Kaynan N,Zeleznjak J,Schu P,Mandelboim O,Krmpotic A,Angulo A,Jonjic S,Lenac Rovis Tdoi
10.7554/eLife.50803subject
Has Abstractpub_date
2020-01-13 00:00:00issn
2050-084Xpii
50803journal_volume
9pub_type
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