The benefits of treating undetectable tumors.

abstract：:Although mRNAs are localized in the processes of excitatory neurons, it is still unclear whether interneurons also localize a large population of mRNAs. In addition, the variability in the localized mRNA population within and between cell types is unknown. Here we describe the unbiased transcriptomic characterization ...

journal_title：eLife

authors： Perez JD,Dieck ST,Alvarez-Castelao B,Tushev G,Chan IC,Schuman EM

更新日期：2021-01-06 00:00:00

abstract：:Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions including mood, learning and memory. However, mechanisms underlying neural stem/progenitor cells (NSPCs) proliferation are not well understood. We found that Agrin, a factor critical for neuromuscular junction formation, is ele...

journal_title：eLife

authors： Zhang H,Sathyamurthy A,Liu F,Li L,Zhang L,Dong Z,Cui W,Sun X,Zhao K,Wang H,Ho HH,Xiong WC,Mei L

更新日期：2019-07-03 00:00:00

abstract：:Synonymous codon usage (SCU) varies widely among human genes. In particular, genes involved in different functional categories display a distinct codon usage, which was interpreted as evidence that SCU is adaptively constrained to optimize translation efficiency in distinct cellular states. We demonstrate here that SC...

journal_title：eLife

authors： Pouyet F,Mouchiroud D,Duret L,Sémon M

更新日期：2017-08-15 00:00:00

abstract：:The prefrontal cortex (PFC)'s functions are thought to include working memory, as its activity can reflect information that must be temporarily maintained to realize the current goal. We designed a flexible spatial working memory task that required rats to navigate - after distractions and a delay - to multiple possib...

journal_title：eLife

authors： Böhm C,Lee AK

更新日期：2020-12-24 00:00:00

abstract：:Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are ...

journal_title：eLife

authors： Çamdere G,Guacci V,Stricklin J,Koshland D

更新日期：2015-11-19 00:00:00

abstract：:Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the focus of connectomic data analysis has been on neurite reconstru...

journal_title：eLife

authors： Staffler B,Berning M,Boergens KM,Gour A,Smagt PV,Helmstaedter M

更新日期：2017-07-14 00:00:00

abstract：:Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein ...

journal_title：eLife

authors： Chau KF,Shannon ML,Fame RM,Fonseca E,Mullan H,Johnson MB,Sendamarai AK,Springel MW,Laurent B,Lehtinen MK

更新日期：2018-05-10 00:00:00

abstract：:The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overexpression increases ...

journal_title：eLife

authors： Ku AT,Shaver TM,Rao AS,Howard JM,Rodriguez CN,Miao Q,Garcia G,Le D,Yang D,Borowiak M,Cohen DN,Chitsazzadeh V,Diwan AH,Tsai KY,Nguyen H

更新日期：2017-05-03 00:00:00

abstract：:Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therap...

journal_title：eLife

authors： Tomek J,Bueno-Orovio A,Passini E,Zhou X,Minchole A,Britton O,Bartolucci C,Severi S,Shrier A,Virag L,Varro A,Rodriguez B

更新日期：2019-12-24 00:00:00

abstract：:The diaphragm muscle is essential for breathing in mammals. Its asymmetric elevation during contraction correlates with morphological features suggestive of inherent left-right (L/R) asymmetry. Whether this asymmetry is due to L versus R differences in the muscle or in the phrenic nerve activity is unknown. Here, we h...

journal_title：eLife

authors： Charoy C,Dinvaut S,Chaix Y,Morlé L,Sanyas I,Bozon M,Kindbeiter K,Durand B,Skidmore JM,De Groef L,Seki M,Moons L,Ruhrberg C,Martin JF,Martin DM,Falk J,Castellani V

更新日期：2017-06-22 00:00:00

abstract：:Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions, HMGCR is ubiquitinated and degraded, but the identity of the E3 ubiqu...

journal_title：eLife

authors： Menzies SA,Volkmar N,van den Boomen DJ,Timms RT,Dickson AS,Nathan JA,Lehner PJ

更新日期：2018-12-13 00:00:00

abstract：:B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...

journal_title：eLife

authors： Bálint Š,Dustin ML

更新日期：2017-03-30 00:00:00

abstract：:Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...

journal_title：eLife

authors： Komondor KM,Carlson AE

更新日期：2020-12-02 00:00:00

abstract：:Adipocyte differentiation is a strictly controlled process regulated by a series of transcriptional activators. Adipogenic signals activate early adipogenic activators and facilitate the transient formation of early enhanceosomes at target genes. These enhancer regions are subsequently inherited by late enhanceosomes....

journal_title：eLife

authors： Watanabe M,Takahashi H,Saeki Y,Ozaki T,Itoh S,Suzuki M,Mizushima W,Tanaka K,Hatakeyama S

更新日期：2015-04-23 00:00:00

abstract：:Calcineurin is responsible for mediating a wide variety of cellular processes in response to dynamic calcium (Ca(2+)) signals, yet the precise mechanisms involved in the spatiotemporal control of calcineurin signaling are poorly understood. Here, we use genetically encoded fluorescent biosensors to directly probe the ...

journal_title：eLife

authors： Mehta S,Aye-Han NN,Ganesan A,Oldach L,Gorshkov K,Zhang J

更新日期：2014-07-23 00:00:00

abstract：:Sudden changes in the level of a coenzyme called NADPH might be the underlying cause of aging in cells. ...

journal_title：eLife

authors： Barral Y

更新日期：2013-02-05 00:00:00

abstract：:During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals. ...

journal_title：eLife

authors： Williams SD,Lewis LD

更新日期：2020-12-23 00:00:00

abstract：:Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in ...

journal_title：eLife

authors： Breckwoldt MO,Bode J,Kurz FT,Hoffmann A,Ochs K,Ott M,Deumelandt K,Krüwel T,Schwarz D,Fischer M,Helluy X,Milford D,Kirschbaum K,Solecki G,Chiblak S,Abdollahi A,Winkler F,Wick W,Platten M,Heiland S,Bendszus M,Tews

更新日期：2016-02-02 00:00:00

abstract：:The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph involving only two am...

journal_title：eLife

authors： Wu NC,Dai L,Olson CA,Lloyd-Smith JO,Sun R

更新日期：2016-07-08 00:00:00

abstract：:In addition to their role in desensitization and internalization of G protein-coupled receptors (GPCRs), β-arrestins are essential scaffolds linking GPCRs to Erk1/2 signaling. However, their role in GPCR-operated Erk1/2 activation differs between GPCRs and the underlying mechanism remains poorly characterized. Here, w...

journal_title：eLife

authors： Cassier E,Gallay N,Bourquard T,Claeysen S,Bockaert J,Crépieux P,Poupon A,Reiter E,Marin P,Vandermoere F

更新日期：2017-02-07 00:00:00

abstract：:When a plant cell divides, four related proteins control the trafficking of vesicles and ensure that cargo that is normally recycled to the plasma membrane is instead re-routed to the plane of cell division. ...

journal_title：eLife

authors： Robatzek S

更新日期：2014-04-08 00:00:00

abstract：:We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan comp...

journal_title：eLife

authors： Kim B,Wang YC,Hespen CW,Espinosa J,Salje J,Rangan KJ,Oren DA,Kang JY,Pedicord VA,Hang HC

更新日期：2019-04-10 00:00:00

abstract：:The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...

journal_title：eLife

authors： Barrett DG,Denève S,Machens CK

更新日期：2016-12-09 00:00:00

abstract：:To effectively interact with their environment, humans must often select actions from multiple incompatible options. Existing theories propose that during motoric response-conflict, inappropriate motor activity is actively (and perhaps non-selectively) suppressed by an inhibitory fronto-basal ganglia mechanism. We her...

journal_title：eLife

authors： Wessel JR,Waller DA,Greenlee JD

更新日期：2019-05-07 00:00:00

abstract：:Metabolic network rewiring is the rerouting of metabolism through the use of alternate enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives. Here, we report the first characterization of two parallel pathways for the breakdown of the short chain fatty acid propionate in Caenorhabditi...

journal_title：eLife

authors： Watson E,Olin-Sandoval V,Hoy MJ,Li CH,Louisse T,Yao V,Mori A,Holdorf AD,Troyanskaya OG,Ralser M,Walhout AJ

更新日期：2016-07-06 00:00:00

abstract：:Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a mala...

journal_title：eLife

authors： Briggs J,Teyssier N,Nankabirwa JI,Rek J,Jagannathan P,Arinaitwe E,Bousema T,Drakeley C,Murray M,Crawford E,Hathaway N,Staedke SG,Smith D,Rosenthal PJ,Kamya M,Dorsey G,Rodriguez-Barraquer I,Greenhouse B

更新日期：2020-10-27 00:00:00

abstract：:Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0-2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will revea...

journal_title：eLife

authors： Ouyang M,Peng Q,Jeon T,Heyne R,Chalak L,Huang H

更新日期：2020-12-22 00:00:00

abstract：:Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie. The FERM protein Expanded is one of the main upstream Hippo signalling regulators in Drosophila as...

journal_title：eLife

authors： Fulford AD,Holder MV,Frith D,Snijders AP,Tapon N,Ribeiro PS

更新日期：2019-09-30 00:00:00

abstract：:Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. Perfori...

journal_title：eLife

authors： McCormack RM,de Armas LR,Shiratsuchi M,Fiorentino DG,Olsson ML,Lichtenheld MG,Morales A,Lyapichev K,Gonzalez LE,Strbo N,Sukumar N,Stojadinovic O,Plano GV,Munson GP,Tomic-Canic M,Kirsner RS,Russell DG,Podack ER

更新日期：2015-09-24 00:00:00

abstract：:Seed dormancy is a complex life history trait that determines the timing of germination and is crucial for local adaptation. Genetic studies of dormancy are challenging, because the trait is highly plastic and strongly influenced by the maternal environment. Using a combination of statistical and experimental approach...

journal_title：eLife

authors： Kerdaffrec E,Filiault DL,Korte A,Sasaki E,Nizhynska V,Seren Ü,Nordborg M

更新日期：2016-12-14 00:00:00