Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell.

abstract：:Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lacked substrate selec...

journal_title：eLife

authors： Chen R,Rato C,Yan Y,Crespillo-Casado A,Clarke HJ,Harding HP,Marciniak SJ,Read RJ,Ron D

更新日期：2015-03-16 00:00:00

abstract：:Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the resultant inflamma...

journal_title：eLife

authors： Gamrekelashvili J,Kapanadze T,Sablotny S,Ratiu C,Dastagir K,Lochner M,Karbach S,Wenzel P,Sitnow A,Fleig S,Sparwasser T,Kalinke U,Holzmann B,Haller H,Limbourg FP

更新日期：2020-07-29 00:00:00

abstract：:We aimed to study time trends and levels of mean total cholesterol and lipid fractions, and dyslipidaemias prevalence in Latin America and the Caribbean (LAC). Systematic-review and meta-analysis of population-based studies in which lipid (total cholesterol [TC; 86 studies; 168,553 people], HDL-Cholesterol [HDL-C; 84 ...

journal_title：eLife

authors： Carrillo-Larco RM,Benites-Moya CJ,Anza-Ramirez C,Albitres-Flores L,Sánchez-Velazco D,Pacheco-Barrios N,Bernabe-Ortiz A

更新日期：2020-08-18 00:00:00

abstract：:We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were foun...

journal_title：eLife

authors： Wang Y,Sundfeldt K,Mateoiu C,Shih IeM,Kurman RJ,Schaefer J,Silliman N,Kinde I,Springer S,Foote M,Kristjansdottir B,James N,Kinzler KW,Papadopoulos N,Diaz LA,Vogelstein B

更新日期：2016-07-15 00:00:00

abstract：:Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV) endocardium. Endocardial Jag1 removal blocks SV capillary sprou...

journal_title：eLife

authors： Travisano SI,Oliveira VL,Prados B,Grego-Bessa J,Piñeiro-Sabarís R,Bou V,Gómez MJ,Sánchez-Cabo F,MacGrogan D,de la Pompa JL

更新日期：2019-12-04 00:00:00

abstract：:The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive ...

journal_title：eLife

authors： Ignatius MS,Hayes MN,Moore FE,Tang Q,Garcia SP,Blackburn PR,Baxi K,Wang L,Jin A,Ramakrishnan A,Reeder S,Chen Y,Nielsen GP,Chen EY,Hasserjian RP,Tirode F,Ekker SC,Langenau DM

更新日期：2018-09-07 00:00:00

abstract：:Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the S...

journal_title：eLife

authors： Vogan AA,Ament-Velásquez SL,Granger-Farbos A,Svedberg J,Bastiaans E,Debets AJ,Coustou V,Yvanne H,Clavé C,Saupe SJ,Johannesson H

更新日期：2019-07-26 00:00:00

abstract：:Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduc...

journal_title：eLife

authors： Gallardo CM,Darvas M,Oviatt M,Chang CH,Michalik M,Huddy TF,Meyer EE,Shuster SA,Aguayo A,Hill EM,Kiani K,Ikpeazu J,Martinez JS,Purpura M,Smit AN,Patton DF,Mistlberger RE,Palmiter RD,Steele AD

更新日期：2014-09-12 00:00:00

abstract：:Candida albicans hyphae can reach enormous lengths, precluding their internalization by phagocytes. Nevertheless, macrophages engulf a portion of the hypha, generating incompletely sealed tubular phagosomes. These frustrated phagosomes are stabilized by a thick cuff of F-actin that polymerizes in response to non-canon...

journal_title：eLife

authors： Maxson ME,Naj X,O'Meara TR,Plumb JD,Cowen LE,Grinstein S

更新日期：2018-03-19 00:00:00

abstract：:Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we reported that NSUN-5 is responsible for depositing m5C at position C2381 on the 26S rRNA in Caenorhabditis elegans. Here, we show that NSUN-1 is writing the second k...

journal_title：eLife

authors： Heissenberger C,Rollins JA,Krammer TL,Nagelreiter F,Stocker I,Wacheul L,Shpylovyi A,Tav K,Snow S,Grillari J,Rogers AN,Lafontaine DLJ,Schosserer M

更新日期：2020-12-08 00:00:00

abstract：:Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene, pdm3, required for sleep maturation in Drosophila. Pdm3, a transcription factor, coordinates an early developmental program ...

journal_title：eLife

authors： Chakravarti Dilley L,Szuperak M,Gong NN,Williams CE,Saldana RL,Garbe DS,Syed MH,Jain R,Kayser MS

更新日期：2020-03-23 00:00:00

abstract：:To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia. We find that leg motor neurons exhi...

journal_title：eLife

authors： Azevedo AW,Dickinson ES,Gurung P,Venkatasubramanian L,Mann RS,Tuthill JC

更新日期：2020-06-03 00:00:00

abstract：:K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility, and indirect flig...

journal_title：eLife

authors： Kronert WA,Bell KM,Viswanathan MC,Melkani GC,Trujillo AS,Huang A,Melkani A,Cammarato A,Swank DM,Bernstein SI

更新日期：2018-08-13 00:00:00

abstract：:Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...

journal_title：eLife

authors： Munshi R,Qadri SM,Zhang Q,Castellanos Rubio I,Del Pino P,Pralle A

更新日期：2017-08-15 00:00:00

abstract：:Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and electrolyte homeostasis...

journal_title：eLife

authors： Scambler T,Jarosz-Griffiths HH,Lara-Reyna S,Pathak S,Wong C,Holbrook J,Martinon F,Savic S,Peckham D,McDermott MF

更新日期：2019-09-18 00:00:00

abstract：:B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...

journal_title：eLife

authors： Bálint Š,Dustin ML

更新日期：2017-03-30 00:00:00

abstract：:Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis...

journal_title：eLife

authors： Lin TC,Su CY,Wu PY,Lai TC,Pan WA,Jan YH,Chang YC,Yeh CT,Chen CL,Ger LP,Chang HT,Yang CJ,Huang MS,Liu YP,Lin YF,Shyy JY,Tsai MD,Hsiao M

更新日期：2016-03-17 00:00:00

abstract：:When a plant cell divides, four related proteins control the trafficking of vesicles and ensure that cargo that is normally recycled to the plasma membrane is instead re-routed to the plane of cell division. ...

journal_title：eLife

authors： Robatzek S

更新日期：2014-04-08 00:00:00

abstract：:Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the parent. Lamina-associated domains (LADs) are regions of repressi...

journal_title：eLife

authors： Poleshko A,Smith CL,Nguyen SC,Sivaramakrishnan P,Wong KG,Murray JI,Lakadamyali M,Joyce EF,Jain R,Epstein JA

更新日期：2019-10-01 00:00:00

abstract：:Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts deficient in Bax/Bak...

journal_title：eLife

authors： Karch J,Schips TG,Maliken BD,Brody MJ,Sargent MA,Kanisicak O,Molkentin JD

更新日期：2017-11-17 00:00:00

abstract：:The characteristics of goal-directed actions tend to resemble those of previously executed actions, but it is unclear whether such effects depend strictly on action history, or also reflect context-dependent processes related to predictive motor planning. Here we manipulated the time available to initiate movements af...

journal_title：eLife

authors： Marinovic W,Poh E,de Rugy A,Carroll TJ

更新日期：2017-10-23 00:00:00

abstract：:Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how Drosophila melanogas...

journal_title：eLife

authors： Fischer CN,Trautman EP,Crawford JM,Stabb EV,Handelsman J,Broderick NA

更新日期：2017-01-09 00:00:00

abstract：:Layer (L) 2/3 pyramidal neurons in the primary somatosensory cortex (S1) are sparsely active, spontaneously and during sensory stimulation. Long-range inputs from higher areas may gate L2/3 activity. We investigated their in vivo impact by expressing channelrhodopsin in three main sources of feedback to rat S1: primar...

journal_title：eLife

authors： Zhang W,Bruno RM

更新日期：2019-02-11 00:00:00

abstract：:Cells can avoid the effects of so-called 'nonsense' mutations by several methods, including a newly discovered mechanism driven by microRNA molecules. ...

journal_title：eLife

authors： Jopling CL

更新日期：2014-09-09 00:00:00

abstract：:Bacillus subtilis can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'. ...

journal_title：eLife

authors： Kim IM,Szurmant H

更新日期：2020-01-24 00:00:00

abstract：:Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. Through carefully chosen parameter fits, solvable in the least-squares sense, we obtain accurate reduced compartmental models at any level of complexity. We show that (back-propagating)...

journal_title：eLife

authors： Wybo WA,Jordan J,Ellenberger B,Marti Mengual U,Nevian T,Senn W

更新日期：2021-01-26 00:00:00

abstract：:Individual recognition (IR) is essential for maintaining various social interactions in a group, and face recognition is one of the most specialised cognitive abilities in IR. We used both a mating preference system and an electric shock conditioning experiment to test IR ability in medaka, and found that signals near...

journal_title：eLife

authors： Wang MY,Takeuchi H

更新日期：2017-07-11 00:00:00

abstract：:Metazoan development depends on tightly regulated gene expression programs that instruct progenitor cells to adopt specialized fates. Recent work found that posttranslational modifications, such as monoubiquitylation, can determine cell fate also independently of effects on transcription, yet how monoubiquitylation is...

journal_title：eLife

authors： Werner A,Baur R,Teerikorpi N,Kaya DU,Rape M

更新日期：2018-07-12 00:00:00

abstract：:Excitatory and inhibitory synapses are the brain's most abundant synapse types. However, little is known about their formation during critical periods of motor skill learning, when sensory experience defines a motor target that animals strive to imitate. In songbirds, we find that exposure to tutor song leads to elimi...

journal_title：eLife

authors： Huang Z,Khaled HG,Kirschmann M,Gobes SM,Hahnloser RH

更新日期：2018-10-25 00:00:00

abstract：:Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug a...

journal_title：eLife

authors： Eicher T,Seeger MA,Anselmi C,Zhou W,Brandstätter L,Verrey F,Diederichs K,Faraldo-Gómez JD,Pos KM

更新日期：2014-09-19 00:00:00