Abstract:
:When a human catches a ball, they estimate future target location based on the current trajectory. How animals, small and large, encode such predictive processes at the single neuron level is unknown. Here we describe small target-selective neurons in predatory dragonflies that exhibit localized enhanced sensitivity for targets displaced to new locations just ahead of the prior path, with suppression elsewhere in the surround. This focused region of gain modulation is driven by predictive mechanisms, with the direction tuning shifting selectively to match the target's prior path. It involves a large local increase in contrast gain which spreads forward after a delay (e.g. an occlusion) and can even transfer between brain hemispheres, predicting trajectories moved towards the visual midline from the other eye. The tractable nature of dragonflies for physiological experiments makes this a useful model for studying the neuronal mechanisms underlying the brain's remarkable ability to anticipate moving stimuli.
journal_name
Elifejournal_title
eLifeauthors
Wiederman SD,Fabian JM,Dunbier JR,O'Carroll DCdoi
10.7554/eLife.26478subject
Has Abstractpub_date
2017-07-25 00:00:00issn
2050-084Xjournal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::Sparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the following key challenges...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26084
更新日期:2017-05-08 00:00:00
abstract::Some anaerobic bacteria use insoluble minerals as terminal electron acceptors and discovering the ways in which electrons move through the membrane barrier to the exterior acceptor forms an active field of research with implications for both bacterial physiology and bioenergy. A previous study suggested that Shewanell...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48054
更新日期:2019-06-24 00:00:00
abstract::Protein synthesis ends when a ribosome reaches an mRNA stop codon. Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nascent protein, and then dissociate to allow ribosome recycling. To visualize termination by RF2, we resolved a cryo-EM ensemble of E. coli 70S•RF2 structures at up to...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46850
更新日期:2019-09-12 00:00:00
abstract::Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells, is well ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49872
更新日期:2019-10-28 00:00:00
abstract::To efficiently navigate through the environment and avoid potential threats, an animal must quickly detect the motion of approaching objects. Current models of primate vision place the origins of this complex computation in the visual cortex. Here, we report that detection of approaching motion begins in the retina. S...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51144
更新日期:2020-02-24 00:00:00
abstract::The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ across families? Using sequencing data from 33 large, three-generation CEPH families, we observed significant variability in parental a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46922
更新日期:2019-09-24 00:00:00
abstract::Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31502
更新日期:2018-02-20 00:00:00
abstract::Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus. It is hypothesized that Cas1 evolved from casposases, a novel class of transposases....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50004
更新日期:2020-01-08 00:00:00
abstract::Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions including mood, learning and memory. However, mechanisms underlying neural stem/progenitor cells (NSPCs) proliferation are not well understood. We found that Agrin, a factor critical for neuromuscular junction formation, is ele...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45303
更新日期:2019-07-03 00:00:00
abstract::Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking selectivity for IN tetramers versus lower order protein oligomers. I...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46344
更新日期:2019-05-23 00:00:00
abstract::Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identified from Congenital...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22617
更新日期:2017-01-20 00:00:00
abstract::Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. The mechanisms that generate these distinct patterns of progeny are poorly understood. U...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36739
更新日期:2018-06-13 00:00:00
abstract::Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01119
更新日期:2013-12-24 00:00:00
abstract::In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. If the two strands of DNA are not identical, there will be mismatches ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28069
更新日期:2017-07-17 00:00:00
abstract::KdpFABC is an ATP-dependent K+ pump that ensures bacterial survival in K+-deficient environments. Whereas transcriptional activation of kdpFABC expression is well studied, a mechanism for down-regulation when K+ levels are restored has not been described. Here, we show that KdpFABC is inhibited when cells return to a ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55480
更新日期:2020-09-21 00:00:00
abstract::The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25413
更新日期:2017-06-06 00:00:00
abstract::Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex (ORC) large subunit, is inherited into newly born cells after it binds to condensing chromosomes during the precedi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12785
更新日期:2016-07-26 00:00:00
abstract::Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hematopoietic cells, including multiple myeloma (MM), lymphoma, and leuk...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47084
更新日期:2019-08-27 00:00:00
abstract::It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages and microglia respond immediately upon oncogene activation in the brai...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31918
更新日期:2018-02-21 00:00:00
abstract::Although several sleep-regulating neuronal populations have been identified, little is known about how they interact with each other to control sleep/wake states. We previously identified neuropeptide VF (NPVF) and the hypothalamic neurons that produce it as a sleep-promoting system (Lee et al., 2017). Here we show us...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54491
更新日期:2020-12-18 00:00:00
abstract::Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the focus of connectomic data analysis has been on neurite reconstru...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26414
更新日期:2017-07-14 00:00:00
abstract::Metabolic network rewiring is the rerouting of metabolism through the use of alternate enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives. Here, we report the first characterization of two parallel pathways for the breakdown of the short chain fatty acid propionate in Caenorhabditi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17670
更新日期:2016-07-06 00:00:00
abstract::Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11288
更新日期:2016-03-17 00:00:00
abstract::Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understoo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10288
更新日期:2016-03-25 00:00:00
abstract::Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18459
更新日期:2017-07-04 00:00:00
abstract::Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking. We show that explanted MZs generate tensile convergence forces up to 1....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26944
更新日期:2018-03-13 00:00:00
abstract::The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals. However, the cell-intrinsic mechanisms that control the distinctive proliferation rates of individual neural stem cells ar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51529
更新日期:2020-01-14 00:00:00
abstract::Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a challenge. There is growing interest in the potential of deep learning models - which predict epigenome features from DNA sequence - to support inference concerning...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51503
更新日期:2020-01-27 00:00:00
abstract::Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11612
更新日期:2016-02-19 00:00:00
abstract::While traditional microbiological freshwater tests focus on the detection of specific bacterial indicator species, including pathogens, direct tracing of all aquatic DNA through metagenomics poses a profound alternative. Yet, in situ metagenomic water surveys face substantial challenges in cost and logistics. Here, we...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61504
更新日期:2021-01-19 00:00:00