当前位置： SCI文献检索 > eLife期刊下所有文献 > The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

Abstract：

:Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis and metastasis. Furthermore, NIFK enhances Ki-67-dependent proliferation, and promotes migration, invasion in vitro and metastasis in vivo via downregulation of casein kinase 1α (CK1α), a suppressor of pro-metastatic TCF4/β-catenin signaling. Inversely, CK1α is upregulated upon NIFK knockdown. The silencing of CK1α expression in NIFK-silenced cells restores TCF4/β-catenin transcriptional activity, cell migration, and metastasis. Furthermore, RUNX1 is identified as a transcription factor of CSNK1A1 (CK1α) that is negatively regulated by NIFK. Our results demonstrate the prognostic value of NIFK, and suggest that NIFK is required for lung cancer progression via the RUNX1-dependent CK1α repression, which activates TCF4/β-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation.

journal_name

Elife

journal_title

eLife

authors

Lin TC,Su CY,Wu PY,Lai TC,Pan WA,Jan YH,Chang YC,Yeh CT,Chen CL,Ger LP,Chang HT,Yang CJ,Huang MS,Liu YP,Lin YF,Shyy JY,Tsai MD,Hsiao M

doi

10.7554/eLife.11288

subject

Has Abstract

pub_date

2016-03-17 00:00:00

issn

2050-084X

journal_volume

5

pub_type

杂志文章

相关文献

eLife文献大全
  • Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.

    abstract：:Neuroligins (NLGNs) are postsynaptic cell adhesion molecules that interact trans-synaptically with neurexins to mediate synapse development and function. NLGN2 is only at inhibitory synapses while NLGN3 is at both excitatory and inhibitory synapses. We found that NLGN3 function at inhibitory synapses in rat CA1 depend...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.19236

    authors： Nguyen QA,Horn ME,Nicoll RA

    更新日期：2016-11-02 00:00:00

  • Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress.

    abstract：:Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fea...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.34135

    authors： Inoue R,Abdou K,Hayashi-Tanaka A,Muramatsu SI,Mino K,Inokuchi K,Mori H

    更新日期：2018-06-26 00:00:00

  • A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation.

    abstract：:TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus. Recent studies have revealed significant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adipocytes. Here, we report that TBP prot...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.08536

    authors： Li L,Martinez SS,Hu W,Liu Z,Tjian R

    更新日期：2015-09-22 00:00:00

  • The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers.

    abstract：:Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a new approach to the problem, as individual subunits adopt a stable...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.17438

    authors： Chadda R,Krishnamani V,Mersch K,Wong J,Brimberry M,Chadda A,Kolmakova-Partensky L,Friedman LJ,Gelles J,Robertson JL

    更新日期：2016-08-03 00:00:00

  • Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes.

    abstract：:In Arabidopsis thaliana, winter is registered during vernalization through the temperature-dependent repression and epigenetic silencing of floral repressor FLOWERING LOCUS C (FLC). Natural Arabidopsis accessions show considerable variation in vernalization. However, which aspect of the FLC repression mechanism is mos...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.57671

    authors： Hepworth J,Antoniou-Kourounioti RL,Berggren K,Selga C,Tudor EH,Yates B,Cox D,Collier Harris BR,Irwin JA,Howard M,Säll T,Holm S,Dean C

    更新日期：2020-09-09 00:00:00

  • Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.

    abstract：:Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.10230

    authors： Rodrigo Albors A,Tazaki A,Rost F,Nowoshilow S,Chara O,Tanaka EM

    更新日期：2015-11-14 00:00:00

  • Sensing the load.

    abstract：:How does the skeleton detect and adapt to changes in the mechanical load it has to carry? ...

    journal_title：eLife

    pub_type： 评论,杂志文章

    doi：10.7554/eLife.50210

    authors： Haelterman N,Lim J

    更新日期：2019-10-07 00:00:00

  • Behavioural diversity of bonobo prey preference as a potential cultural trait.

    abstract：:The importance of cultural processes to behavioural diversity in our closest living relatives is central to revealing the evolutionary origins of human culture. However, the bonobo is often overlooked as a candidate model. Further, a prominent critique to many examples of proposed animal cultures is premature exclusio...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.59191

    authors： Samuni L,Wegdell F,Surbeck M

    更新日期：2020-09-01 00:00:00

  • Assembling the Tat protein translocase.

    abstract：:The twin-arginine protein translocation system (Tat) transports folded proteins across the bacterial cytoplasmic membrane and the thylakoid membranes of plant chloroplasts. The Tat transporter is assembled from multiple copies of the membrane proteins TatA, TatB, and TatC. We combine sequence co-evolution analysis, mo...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.20718

    authors： Alcock F,Stansfeld PJ,Basit H,Habersetzer J,Baker MA,Palmer T,Wallace MI,Berks BC

    更新日期：2016-12-03 00:00:00

  • Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function.

    abstract：:Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycolytic flux and limite...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.30938

    authors： Bettonville M,d'Aria S,Weatherly K,Porporato PE,Zhang J,Bousbata S,Sonveaux P,Braun MY

    更新日期：2018-06-18 00:00:00

  • The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit.

    abstract：:Gustatory pheromones play an essential role in shaping the behavior of many organisms. However, little is known about the processing of taste pheromones in higher order brain centers. Here, we describe a male-specific gustatory circuit in Drosophila that underlies the detection of the anti-aphrodisiac pheromone (3R,11...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.06914

    authors： Shankar S,Chua JY,Tan KJ,Calvert ME,Weng R,Ng WC,Mori K,Yew JY

    更新日期：2015-06-17 00:00:00

  • Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.

    abstract：:Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.01119

    authors： Mowers J,Uhm M,Reilly SM,Simon J,Leto D,Chiang SH,Chang L,Saltiel AR

    更新日期：2013-12-24 00:00:00

  • Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.

    abstract：:Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.25014

    authors： Banerjee JJ,Aerne BL,Holder MV,Hauri S,Gstaiger M,Tapon N

    更新日期：2017-06-30 00:00:00

  • Previously undetected super-spreading of Mycobacterium tuberculosis revealed by deep sequencing.

    abstract：:Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether 'deep' sequencing can provide additional resolution compared to standard sequencing, using a well-characterized outbreak from the Arctic (2011-201...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.53245

    authors： Lee RS,Proulx JF,McIntosh F,Behr MA,Hanage WP

    更新日期：2020-02-04 00:00:00

  • Anatomical organization of presubicular head-direction circuits.

    abstract：:Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS). We found that layer2 is composed of two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted the contralater...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.14592

    authors： Preston-Ferrer P,Coletta S,Frey M,Burgalossi A

    更新日期：2016-06-10 00:00:00

  • Shorter cortical adaptation in dyslexia is broadly distributed in the superior temporal lobe and includes the primary auditory cortex.

    abstract：:Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster th...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.30018

    authors： Jaffe-Dax S,Kimel E,Ahissar M

    更新日期：2018-02-28 00:00:00

  • Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition.

    abstract：:The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literat...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.50601

    authors： Guthman EM,Garcia JD,Ma M,Chu P,Baca SM,Smith KR,Restrepo D,Huntsman MM

    更新日期：2020-01-09 00:00:00

  • Finding a worm's internal compass.

    abstract：:A pair of neurons is required for nematodes to be able to navigate using the Earth's magnetic field. ...

    journal_title：eLife

    pub_type： 评论,杂志文章

    doi：10.7554/eLife.09666

    authors： Rankin CH,Lin CH

    更新日期：2015-08-05 00:00:00

  • A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model.

    abstract：:Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain indu...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.08733

    authors： Arima Y,Kamimura D,Atsumi T,Harada M,Kawamoto T,Nishikawa N,Stofkova A,Ohki T,Higuchi K,Morimoto Y,Wieghofer P,Okada Y,Mori Y,Sakoda S,Saika S,Yoshioka Y,Komuro I,Yamashita T,Hirano T,Prinz M,Murakami M

    更新日期：2015-08-11 00:00:00

  • Notch and TLR signaling coordinate monocyte cell fate and inflammation.

    abstract：:Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the resultant inflamma...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.57007

    authors： Gamrekelashvili J,Kapanadze T,Sablotny S,Ratiu C,Dastagir K,Lochner M,Karbach S,Wenzel P,Sitnow A,Fleig S,Sparwasser T,Kalinke U,Holzmann B,Haller H,Limbourg FP

    更新日期：2020-07-29 00:00:00

  • Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer.

    abstract：:Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.54095

    authors： Burfeind KG,Zhu X,Norgard MA,Levasseur PR,Huisman C,Buenafe AC,Olson B,Michaelis KA,Torres ER,Jeng S,McWeeney S,Raber J,Marks DL

    更新日期：2020-05-11 00:00:00

  • Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks.

    abstract：:Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relating gamma oscillations, synaptic strength and circuit computations ar...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.06444

    authors： Solanka L,van Rossum MC,Nolan MF

    更新日期：2015-07-06 00:00:00

  • Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly.

    abstract：:The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test the hypothesis that inter-individual microbiota variation can arise solely from differences in the order and timing by which the gut is colonized early in life. Experiments in which mice were inoculated in sequence eith...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.36521

    authors： Martínez I,Maldonado-Gomez MX,Gomes-Neto JC,Kittana H,Ding H,Schmaltz R,Joglekar P,Cardona RJ,Marsteller NL,Kembel SW,Benson AK,Peterson DA,Ramer-Tait AE,Walter J

    更新日期：2018-09-18 00:00:00

  • CDK9-dependent RNA polymerase II pausing controls transcription initiation.

    abstract：:Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.29736

    authors： Gressel S,Schwalb B,Decker TM,Qin W,Leonhardt H,Eick D,Cramer P

    更新日期：2017-10-10 00:00:00

  • Caught in a TrAP.

    abstract：:Some DNA viruses overcome plant defenses by producing a suppressor protein that blocks the silencing of viral genes. ...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.11509

    authors： Ré DA,Manavella PA

    更新日期：2015-10-16 00:00:00

  • Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively.

    abstract：:Previous research showed that spontaneous neuronal activity presents sloppiness: the collective behavior is strongly determined by a small number of parameter combinations, defined as 'stiff' dimensions, while it is insensitive to many others ('sloppy' dimensions). Here, we analyzed neural population activity from the...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.53268

    authors： Ponce-Alvarez A,Mochol G,Hermoso-Mendizabal A,de la Rocha J,Deco G

    更新日期：2020-03-17 00:00:00

  • Optogenetic investigation of BMP target gene expression diversity.

    abstract：:Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis. We systematically identified target genes responding to BMP and found tha...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.58641

    authors： Rogers KW,ElGamacy M,Jordan BM,Müller P

    更新日期：2020-11-11 00:00:00

  • Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development.

    abstract：:Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB o...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.55263

    authors： Manzano Nieves G,Bravo M,Baskoylu S,Bath KG

    更新日期：2020-07-21 00:00:00

  • Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine.

    abstract：:The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes th...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.42914

    authors： Li Z,Hao MM,Van den Haute C,Baekelandt V,Boesmans W,Vanden Berghe P

    更新日期：2019-02-12 00:00:00

  • Insights into the evolution of social systems and species from baboon studies.

    abstract：:Baboons, members of the genus Papio, comprise six closely related species distributed throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological flexibility and a wider range of social systems than many other primates. This article summarizes our current knowledge of the natural history of...

    journal_title：eLife

    pub_type： 杂志文章

    doi：10.7554/eLife.50989

    authors： Fischer J,Higham JP,Alberts SC,Barrett L,Beehner JC,Bergman TJ,Carter AJ,Collins A,Elton S,Fagot J,Ferreira da Silva MJ,Hammerschmidt K,Henzi P,Jolly CJ,Knauf S,Kopp GH,Rogers J,Roos C,Ross C,Seyfarth RM,Silk J,

    更新日期：2019-11-12 00:00:00